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UW APL & CIE Invention to Start Up Jack Gallagher Pierre Mourad

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UW APL & CIE Invention to Start Up Jack Gallagher Pierre Mourad. Agenda. How We Got Started University Resources Intellectual Property Building a Team Business Plan Funding Sources Research Process & Evolution Research Concept Findings Questions. How We Got Started.

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Presentation Transcript
slide1

UW

APL & CIE

Invention to Start Up

Jack Gallagher

Pierre Mourad

agenda
Agenda
  • How We Got Started
  • University Resources
  • Intellectual Property
  • Building a Team
  • Business Plan
  • Funding Sources
  • Research Process & Evolution
  • Research Concept Findings
  • Questions
how we got started
How We Got Started
  • Random meeting with Allez PhysiOnix
  • Started research at UW in August 2003 (WTC Grants)
  • Negotiated exclusive license to UW technology (Tech Transfer)
  • First patent published in 2005 (Tech Transfer)
  • Funding from founders, private investors (Angels & Venture Capital), WTC research grants, NIH Phase 1 and 2 SBIR grants
university resources
University Resources
  • Applied Physics Laboratory
  • Department of Neurological Surgery
  • Schools of Dentistry and of Public Health
  • Office of Technology Transfer
  • Washington Technology Center (WTC)
  • Washington Research Foundation (WRF Capital)
intellectual property
Intellectual Property
  • Get a good patent attorney
  • Extensive review of 500 patents before started
  • Patent filed November 2003 (published May 05)
  • Additional patents filed in 2006
building a team
Building a Team
  • Start with Technical Types
    • Build & prove out technology
  • Need 1 Business / Marketing Type
    • Build vision of future, negotiations, legal work, fund raising
  • Start part time; eventually convert to full time
business plan
Business Plan
  • How big is the market
  • What is your reason for being i.e. competitive advantage
  • What is your anticipated market share
  • Projected pricing
  • Estimated spending by year
  • Planned exit (Sale, IPO)
  • Capital requirements by year
  • Fund raising strategy
funding sources
Funding Sources
  • Need a strategy
  • Founders
  • Washington Technology Center (WTC)
  • National Institutes of Health (NIH)
  • Angels
  • Venture Capital
evolution of research

Internal Testing:

what are the primary benefits?

Concept Testing:

does the concept deliver a benefit?

Evolution of Research

2004-2006

2006-2007

2005-2006

2003-2004

External Testing:

independent confirmation of safety & effectiveness

Optimize Parameters:

what is the optimal technology design?

Univ. of Wash.

& Ultreo

NIH SBIR Phase I Grant

Ultreo, Inc. & Universities

NIH SBIR Phase II Grant

University of Washington

WTC Grants

Ultreo, Inc.

NIH SBIR Phase II Grant

some details of the research
some details of the research
  • What is old, and how and what old does
  • What is new, and how and what new does
  • More of what new does
  • Summary statement of some partnering lessons I’ve learned
manual brushes
manual brushes
  • manual brushes move several times per second and clean only at the point of bristle contact
power brushes
power brushes
  • power brushes move their bristles several hundred times per second and clean primarily at the point of bristle contact, in a manner vastly more efficient than manual brushes.
power brushes1
power brushes
  • However, even the best power brushes still leave behind significant amounts of plaque in your mouth, much of it in areas where the bristles don’t contact.

www.studentbmj.com/issues/00/10/education/369.php

what is special about the ultreo
what is special about the Ultreo
  • we’ve added optimally configured and delivered ultrasound to a power toothbrush foundation.
what is special about the ultreo1
what is special about the Ultreo
  • the Ultreo’s bristles scrub on time scales similar to that of other power toothbrushes - hundreds of times a second.

Thanks to the ultrasound-activated bubbles, the Ultreo also removes plaque bacteria where the ultrasound and dental slurry intersect, including where the bristles may not reach.

we ve come a long way
we’ve come a long way

vs

  • a testimony to the initial vision, the initially applied resources and alacrity of SAP/APL/Neurosurgery/Pediatric Dentistry/Periodontology/Public Health, and the subsequent and considerable effort and expertise utilized at Ultreo, along with continuing efforts of UW.
ultrasound from a stationary brush rapidly removes a line of plaque bacteria
ultrasound from a stationary brush rapidly removes a ‘line’ of plaque bacteria.
  • Artificial teeth with bacteria dyed pink before (left) and after (right) application of ultrasound without bristle contact. Discrete bacteria colonies along a band stretching from lower left to upper right were removed by the ultrasound activated bubbles, in a shape corresponding to the shape of ultrasound emitted from the face of the stationary brush head.
plaque bacteria removal via combined sonic ultrasound processes
plaque bacteria removal via combined sonic & ultrasound processes
  • Artificial teeth with bacteria dyed pink before (left) and after (right) treatment with a sonically vibrating brush head that emitted ultrasound in the presence of sonically produced bubbles, 2-3 mm from the artificial teeth. Discrete bacteria colonies were reduced or removed across the entire tooth surface after only 5 seconds of application of the prototype.
sonic ultrasound versus sonic only
sonic & ultrasound versus sonic only
  • Artificial teeth with bacteria dyed pink before (above) and after (below) treatment with (AA’) a sonically vibrating brush head that emitted ultrasound in the presence of sonically produced bubbles or (BB’) a popular power toothbrush, each acting 2-3 mm from the artificial teeth. Bacteria were removed across the entire tooth surface after only 5 seconds of application of the prototype.
partnership lessons
partnership lessons
  • assuming sufficient technical skills, it is the character of the people with whom you work that matters the most.
  • start your research with the clinical problem in mind.
  • be open to new perspectives and to new knowledge.
  • appreciate the opportunities afforded by serendipity and be willing to act, quickly!, in response to those opportunities.
  • surround yourself with (interdisciplinary) people who sufficiently interact and are open to the fruits of those interactions.
  • make sure your environment facilitates and nurtures those interactions.
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