Bioenergy Life Science CK Foods

2. 2 Bioenergy Profile Ribose Overview Selected Clinical Studies New Research Looking Ahead�

3. Founded by physicians Pioneered in the medical channel Expanded to supplement and ingredient markets Currently over 100 supplement and 50 food/bev. Customers including� Pepsi, Sobe, Vitamin Water, Snapple, & Go Fast 3

4. World experts and best resource of ribose Highest quality service and product We continue to provide research-based applications 4

5. ��other supplements(i.e. vitamins), including many herbs, will likely see a continuing decline over 2007-2012. In most cases this will be due to the absence of scientific basis behind product claims�� ~Euromonitor International

6. Patents Bioenergy pursues an aggressive policy of obtaining patent protection covering substantially all uses of ribose. Bioenergy holds: 15 United States patents issued 25+ pending or provisional applications. Some of these have extensive foreign counterparts on file. 3 European patents 4 Great Britain patents 2 Chinese patents 6

7. Energy Broad Applications All Uses of Energy in Mammals Fibromyalgia Recommended Ribose and Malate Improves Immune Function Viability of a Myocardial Segment Cramping and Soreness in Muscles (pending)

8. New & Existing Products with Ribose 8

9. Melanie Roach Eric Butorac 9

10. 10 11 World Cup Medals 6 WC Medals in 2009 4 time American Record Holder 2009 US National Champion 2008 World Championships Overall Rank � 7th 2009 World Championships Overall Rank 3rd

11. 11 2 Time Olympian (�02 and �06) 2002 Olympic Silver Medalist 2007 World Championships Silver Medalist 2003 World Cup Champion 22 time World Cup medalist (7 Gold) 2009 National Champion

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17. Ischemia Changes Energy Balance and Concentration 17 Here is what happens to ATP in an extreme example like a heart attack. The first column is a normal quantity and distribution of ATP, ADP, and AMP (called purine nucleotides). Most of this is ATP with smaller amounts of the other two. ADP and AMP have lesser amounts of energy, but they do have some. Then a heart attack strikes. A major coronary artery is blocked and blood (oxygen) is denied to the tissue down stream. You are rushed to the hospital in record time, but in less than 30 minutes, both the quantity and mix of these purine nucleotides has changed. You have lost a large quantity of purine nucleotides, and those you have left are of much lower energy. You are in major trouble. Fortunately, you have a great doctor in the ER who quickly administers a drug to break up the clot and circulation is restored. Your heart starts to get oxygen again and the healthy ratio of nucleotides is restored. But look what you have lost. Even now with adequate O2, you don�t have as much energy (ATP) as you did before. You feel �like I�ve been run over by a train�, you are so weak. You are admitted to the CCU and can plan to be about 10 days to 2 weeks before you begin to get your energy back. Here is what happens to ATP in an extreme example like a heart attack. The first column is a normal quantity and distribution of ATP, ADP, and AMP (called purine nucleotides). Most of this is ATP with smaller amounts of the other two. ADP and AMP have lesser amounts of energy, but they do have some. Then a heart attack strikes. A major coronary artery is blocked and blood (oxygen) is denied to the tissue down stream. You are rushed to the hospital in record time, but in less than 30 minutes, both the quantity and mix of these purine nucleotides has changed. You have lost a large quantity of purine nucleotides, and those you have left are of much lower energy. You are in major trouble. Fortunately, you have a great doctor in the ER who quickly administers a drug to break up the clot and circulation is restored. Your heart starts to get oxygen again and the healthy ratio of nucleotides is restored. But look what you have lost. Even now with adequate O2, you don�t have as much energy (ATP) as you did before. You feel �like I�ve been run over by a train�, you are so weak. You are admitted to the CCU and can plan to be about 10 days to 2 weeks before you begin to get your energy back.

18. 18 Availability of Ribose Accelerates Recovery

19. 19 Bioenergy ribose studies fall into 3 major groups

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21. Hearts require a lot of energy to function properly Ribose has been shown to improve heart function thru a wide array of clinical work over the last 30 years Cardiovascular Clinical Research 21 6/3/2012

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23. 23 Improved Endurance Increased muscle strength and endurance Improved ventilatory efficiency Improved cardiac function Accelerated Recovery Improved purine nucleotide salvage (ATP recovery) Free radical management Hellsten, 2004. Seifert, 2002. Van Gammeren, 2002. Brault, 2001. Orly Carter, 2005. Williamson, 2001. Stout Wagner, 1991 Gross, 1991

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25. 25 Ribose Reduces Oxidative Stress & Peak Heart Rate 7-healthy, normal volunteers Double blind, placebo controlled, crossover design Cycle exercise at lactic acid threshold while breathing 16% O2 (induced hypoxia) Measurements MDA (urine) and reduced glutathione (GSH; whole blood) Heart rate (at fixed level of exercise) Various metabolic parameters

26. 26 Free Radical Formation & Glutathione Depletion The ribose group glutathione level fell significantly in the plasma indicating it provides an anti-oxidant effect by preserving glutathione. The ribose group glutathione level fell significantly in the plasma indicating it provides an anti-oxidant effect by preserving glutathione.

27. 27 Ribose Protects Against Free Radicals Lowered urinary MDA Reduced cell wall damage and lipid peroxidation Modified plasma glutathione levels Bypasses G-6-Pdh to cycle GSH and GSSG Produces NADPH for GSSG cycling to GSH Controls hepatic and muscle release of GSH to blood Reduced heart rate at similar exercise intensities during hypoxic stress

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29. Dose Size 3-7gm efficacious dose Dose Timing Ribose loading ineffective Work Load Performed Anaerobic threshold for ATP depletion Op't Eijnde B, 2001. Berardi JM, 2003. Falk DJ, 2003. Kerksick, 2005. Dunne L, 2006. Peveler WW, 2006.

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32. 32 Trial study parameters

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36. 36 VO2 @ AT is a measure of aerobic fitness. It determines the amount of oxygen consumed per minute. By increasing the VO2 @ AT, subjects are able to do more work with less fatigue.

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39. Subjectively, ribose supplementation provides a perceived improvement in: vitality and fatigue mental outlook Objective (CPX) data demonstrated that ribose increased: exercise tolerance aerobic capacity oxygen uptake and utilization ventilation efficiency cellular metabolism and work capacity 39

40. ENERGY- Natural, Sustainable No Crash Nothing Else Works Like Ribose for Endurance Recovery Works Well With Other Ingredients

41. Non-GMO Natural Kosher and Halal certified GRAS Affirmed Novell foods and Parnus status dossier have been submitted and reviewed without objection 41

42. Clinical research results supporting the following claims: Speeds energy recovery Increases energy reserves Builds ATP in heart and muscle Maintains healthy energy levels in heart and muscle Relieves post-exertional muscle cramping and soreness Quality of life is enhanced Increases tolerance to cardiac stress Improves exercise tolerance and physical function Provides healthy levels of cardiac energy needed to maintain normal heart function Improves physical performance Increases athletic performance Decreases free radical formation during exercise Increases the hypoxic threshold of tissue Increases cardiac efficiency and lowers stress during exercise 42

43. Expanded low dose energy study 2009 athletic clinical study Recovery Endurance Cardiovascular clinical study Chronic pain clinical trail 2010 Olympics Katherine Reutter Shannon Bahrke