Preparation of nih grant applications
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Preparation of NIH Grant Applications. Karl Salzwedel NIH Grantsmanship Workshop Kuala Lumpur, Malaysia July 2, 2013. Find Answers and Plan Your Approach www.niaid.nih.gov. The NIH Grant Application Lifecycle. www.niaid.nih.gov / researchfunding / grant. Where to Start.

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Preparation of nih grant applications

Preparation of NIH Grant Applications

Karl Salzwedel

NIH Grantsmanship Workshop

Kuala Lumpur, Malaysia

July 2, 2013


Preparation of nih grant applications

Find Answers and Plan Your Approach

www.niaid.nih.gov


The nih grant application lifecycle

The NIH Grant Application Lifecycle

www.niaid.nih.gov/researchfunding/grant


Where to start

Where to Start

Researching the best fit for you is critical

Some things to consider:

To which grants are you eligible to apply ?

What is the best grant mechanism for your situation?

How much preliminary data do you have?

What is the potential impact of your research to the field?

How novel is your idea?

Is this something that the NIH is looking to fund (solicited vs. unsolicited)?

Is it best to apply as a principal investigator, co-investigator or collaborator?


Preparation of nih grant applications

Which grant mechanism is right for you?

www.grants.nih.gov/grants/guide/parent_announcements

Ph.D. Career Development Awards

K22- Research Scholar Development Award

K99/R00- Pathway to Independence Award

M.D. Career Development Awards

K08- Mentored Clinical Scientist Development Award

K23- Mentored Patient-Oriented Research Career Development Award

Independent Research Grants

R03- Small Grant

R21- Exploratory/Developmental Research Grant

R01- Research grant

R03

R21

R01

K22

K99/

R00

Ph.D.

M.D.

K08

K23

Training

Faculty position

Independent PI


Career award selection

Career Award Selection

www.grants.nih.gov/training/kwizard

K23

K99

K22

K08

K01


K22 and the k99 r00 award features

K22 and the K99/R00 Award Features

K22

  • 2 yr award

  • No mentored phase

  • Awardee gets funds at the time of becoming asst. professor

  • $150K (year 1) direct costs + $100K (year 2) direct costs + 8% F&A

  • Must have less than 5 years postdoctoral experience

K99/R00

  • 3 year award only

  • Up to 1 yr mentored phase ($90K/yr)

  • Awardee becomes asst. professor- No peer review

  • 2 yr independent R phase ($249K/yr TC)

  • Citizenship and green card not required- unique to this K mechanism

  • Must have less than 5 years postdoctoral experience

http://grants.nih.gov/training/careerdevelopmentawards.htm


K08 and the k23 award features

K08 and the K23 Award Features

K08

  • Up to 5 year award

  • Mentored clinical research

  • Minimum 75% effort required

  • Allows other support in last 2 years*

  • Up to $75K salary + fringe benefits+ $25K research costs

  • Does not support new clinical trials

K23

  • Up to 5 year award

  • Mentored patient-orientedresearch

  • Minimum 75% effort required

  • Allows other support in last 2 years*

  • Up to $75K salary + fringe benefits+ $25K research costs

  • Does not support new clinical trials

http://funding.niaid.nih.gov/researchfunding/tool/pages/traincareercomp.aspx


Preparation of nih grant applications

International Applicants

  • Most K-awards require U.S. citizenship (exception:K99)

  • Eligible for R03, R21, R01 research grants

  • Opportunities specific to international scientists (RFAs)

www.niaid.nih.gov/researchfunding/int


What does the nih currently fund www projectreporter nih gov

What does the NIH currently fund?www.projectreporter.nih.gov


Specific aims

Specific Aims

  • The most critical page in the application

  • Aone page summary of the application

    • Why is this problem significant?

    • What is the exciting preliminary data?

    • What are the hypotheses supported by the data?

    • How will this project significantly impact the field?

    • Make sure to emphasize important points that you absolutely want the reviewer to know

    • Make them want to keep reading

    • Avoid simply listing things you are going to do


Common pitfalls

Common Pitfalls

  • Proposed project is not novel or innovative

  • Even if project is successful will have questionable impact to the field

  • Failure to convince reviewers of scientific rationale for proposed studies

  • Research is mainly descriptive or correlative –’looking at’ bad, testing good

  • Lack of clear, testable hypothesis – ‘fishing expedition’

  • Inadequate preliminary data to support a large investment

  • Unfocused research plan

  • Lack of experience in the proposed methodology

  • Insufficient publication record

  • Uncertainty concerning the future directions

  • Failure to consider potential pitfalls/alternative approaches

  • Unrealistically large amount of work

  • Lack of statistical considerations


Things to keep in mind

Things to keep in mind

  • Don’t work in a vacuum - actively seek out advice, collaborators/consultants to strengthen your proposal

  • Follow instructions - page limits, font size, margins

  • Be concise and clear - tables, figures clearly numbered with legends/footnotes

  • Letters of collaboration should clearly state what the collaborators/consultants have to offer

  • Allow sufficient time for honest feedback on draft proposal from colleagues/peers

  • Reviewers’ have zero tolerance for typos and bad grammar


Preparation of nih grant applications

Summary: Hallmarks of an Outstanding Grant Application

Strong significance to an important problem in public health: IMPACT is high

High degree of novelty and innovation

Strong track record by a well qualified applicantand collaborators

Clear rationale

Relevant and supportive preliminary data

Clear and focused approach that provides unambiguous results

Careful attention to details

Presentation, readability, clarity of data, graphics, error bars, spelling, etc


Preparation of nih grant applications

www.niaid.nih.gov/researchfunding/ann/pages/opps


I m from the government and i m here to help

“I’m from the government and I’m here to help”

  • PO - Program Officer

    • Responsible for directing and evaluating research programs and scientific administration of your grant

  • SRO - Scientific Review Officer

    • Responsible for peer review of your application

  • GMS - Grants Management Specialist

    • Responsible for the fiscal and federal policy administration of your grant


Niaid funding opportunities in hiv aids research

NIAID Funding Opportunities in HIV/AIDS Research

Karl Salzwedel

Division of AIDS, NIAID, NIH

July 2, 2013


Preparation of nih grant applications

NIAID conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases.


The division of aids daids

The Division of AIDS (DAIDS)

Scientific Programs

Basic Sciences Program

Therapeutics Research Program

Prevention Sciences Program

Vaccine Research Program


Steps along the hiv cure pathway

Steps Along the HIV Cure Pathway

  • Clinical Trials Networks: Cure Agenda (UM1)

FY14

FY12

Beyond HAART:  Innovative Therapies to Control HIV-1 (P01)

Delivering Therapeutics to Residual ActiveHIV Reservoirs RFA (R01)

FY14

  • Targeting Persistent HIV Reservoirs (TaPHIR) PAR (R21/R33)

FY13

FY11

Martin Delaney Collaboratory:  Towards an HIV-1 Cure (U19)


New funding initiatives for 2015

New Funding Initiatives for 2015

  • Clinical Trials Networks: Cure Agenda (UM1)

Pilot Clinical Trials to Eliminate the Latent Reservoir (U01)

New

New

Beyond HAART II Innovative Therapies to Control HIV (U19)

Beyond HAART:  Innovative Therapies to Control HIV-1 (P01)

Delivering Therapeutics to Residual Active HIV Reservoirs RFA (R01)

Quantitative Viral Outgrowth Assay (Q-VOA) Service Resource (N01)

New

Targeting Latently Infected Cells Without Reactivation (R01)

New

  • Targeting Persistent HIV Reservoirs (TaPHIR) PAR (R21/R33)

Innovative Assays to Quantify the Latent HIV Reservoir (R21, R01)

New

Martin Delaney Collaboratory:  Towards an HIV-1 Cure (U19)


Nih aids reagent program

NIH AIDS Reagent Program

Provides standardized reagents and new technologies to the

AIDS research community

  • Viruses

  • Cell lines, hybridomas

  • Monoclonal and polyclonal antibodies

  • DNA clones, DNA libraries, expression vectors

  • Recombinant proteins, synthetic peptides

  • Reference panels for:

    • PCR

    • HIV subtyping

    • Drug resistant viruses

    • Neutralizing antibodies and sera

  • Antiviral drug standards

http://www.aidsreagents.org


Preparation of nih grant applications

U.S. institutions with funding to provide shared infrastructure support for HIV research

CFARs support a multidisciplinary, collaborative environment that promotes basic, clinical, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS.

Web site: www.niaid.nih.gov/LabsAndResources/resources/cfar


Preparation of nih grant applications

CFAR

  • One mission of the CFAR is to strengthen capacity for HIV/AIDS research in developing countries.

  • CFARs accomplish this through a variety of ways including:

    • Establishment of Cores abroad which provide training, services and expertise to local investigators

    • Provide funding for pilot projects with an international component through the CFAR Developmental Core

    • Offer training/mentorship in-country or in US

  • Access to databases, repositories, computer-based training


Cfars are a trans nih program

CFARs are a Trans-NIH Program

Co-funded by nine NIH Institutes:

National Institute of Allergy and Infectious Diseases (NIAID)

National Cancer Institute (NCI)

National Institute of Child Health and Human Development (NICHD)

National Heart, Lung and Blood Institute (NHLBI)

National Institute on Drug Abuse (NIDA)

National Institute on Mental Health (NIMH)

National Institute on Aging (NIA)

National Institute of General Medical Sciences (NIGMS)

National Institute of Nursing Research (NINR)

Co-managed by the NIH Institutes above, and by:

Office of AIDS Research (OAR)

Fogarty International Center (FIC)


Centers for aids research

CENTERS FOR AIDS RESEARCH


Preparation of nih grant applications

CFAR-Funded International HIV/AIDS Research

India (5)

Romania (1)

Russia (1)

Canada (1)

China (4)

Cambodia (1)

Democratic Republic

of Congo (1)

Haiti (1)

Ethiopia (1)

Mexico (4)

Uganda (12)

Ghana (2)

Kenya (26)

Guatemala (1)

Rwanda (4)

Tanzania (11)

Cameroon (1)

Mozambique (4)

Peru (3)

Zambia (5)

Zimbabwe (2)

Namibia (2)

Brazil (1)

Malawi (8)

Australia (2)

Botswana (10)

South Africa (20)

CFAR projects funded 2009-2012

Updated June 2012


Creative and novel ideas in hiv research cnihr encouraging innovation in hiv research

Creative and Novel Ideas in HIV Research (CNIHR)Encouraging Innovation in HIV Research

  • Goal: to attract both international and U.S.-based early stage investigators from outside the field of HIV research

  • Up to 2 yrs, $150k per year Direct Costs

  • Concept sheets (2 pages) will be submitted by October 16, 2013

www.cnihr.org


Preparation of nih grant applications

  • These are U01, collaborative grants, which establishinternational regional centers

    • Foster collaboration on HIV research on regional and global level

    • Advance methodology for collection and harmonization of data

    • Address research questions using data sets


Preparation of nih grant applications

7 Funded Regions

Region 1: North America

Region 5: Australia, China, India, Pakistan, Asia (excluding Central Asia)

Region 2: Latin America

& Caribbean (CCASAnet)

Region 8: West Africa

Region 9: Central Africa

Region 11: South Africa

Region 10: East Africa


International research in infectious diseases including aids irida program r01

International Research in Infectious Diseases including AIDS (IRIDA) Program (R01)

PAR-11-145

Objective: to advance the development of local scientific expertise, build local research infrastructure, and to increase collaborative research partnerships at resource limited eligible foreign countries that propose research related to infectious diseases that are of interest to that country

Application Receipt Date for AIDS Applications:

August 23, 2013

Contact (for HIV/AIDS Research):

OpendraSharma, Ph.D.

Telephone: (301) 496-9041

Email: [email protected]

http://grants.nih.gov/grants/guide/pa-files/PAR-11-145.html


In summary

In Summary

There are many opportunities − researching the best fit for what you wish to do is critical.

  • Karl Salzwedel, [email protected]

  • Diana Finzi, [email protected]

  • Ann Namkung Lee,[email protected]


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