Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity
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Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity. Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America 27 th Annual Meeting Montreal, Canada November 5-9, 2006. Acknowledgement. Funding for this project was provided by

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Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity

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Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity

Joy McGrath

Dominic Di Toro

HydroQual, Inc.

SETAC North America 27th Annual Meeting

Montreal, Canada

November 5-9, 2006


Acknowledgement

Funding for this project was provided by

the Coastal Response Research Center

www.crrc.unh.edu


Acute Toxicity QSARs for Narcotics


Computation of Effect Concentrations


Acute Effects (lethality) – Single Exposures

Water Column

Sediment


Chronic Effects (Growth, Reproduction, Mortality) – Single Exposures


Water Column – Chronic Sublethal Effects


90% Confidence Limits in Predicted Effect Concentration


Water Column – Other Chronic Sublethal Effects - PAH Mixtures

Rhodes et al, 2005


HC5 Values for Water and Sediment


Comparison of HC5s and NOECs for PAHs

WATER

SEDIMENT


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