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Lecture 14: Gene interactions

Lecture 14: Gene interactions . Announcements. Exam 2 next Tuesday: Material for problem solving – up through Homework 7 (practice problems at back of Chapters 4, 5, 20) Material for other questions: through today’s lecture (Chapters 4, 5, 6, 20) Bring a calculator and a #2 pencil.

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Lecture 14: Gene interactions

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  1. Lecture 14: Gene interactions

  2. Announcements Exam 2 next Tuesday: Material for problem solving – up through Homework 7 (practice problems at back of Chapters 4, 5, 20) Material for other questions: through today’s lecture (Chapters 4, 5, 6, 20) Bring a calculator and a #2 pencil

  3. Complementation testing

  4. Suppressor alleles

  5. Synthetic lethal alleles

  6. Variable penetrance Red = mutant genotype, has phenotype Pink = mutant genotype, no phenotype

  7. Variable expressivity piebald spotting in beagles (SP allele) Drosophila eyeless gene

  8. Penetrance vs. expressivity

  9. Pleiotropy Frizzled mutation in chickens Other phenotypic effects: abnormal body temperature, higher metabolic rate, fewer eggs

  10. Temperature-sensitive mutations

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