Synthesis of cortistatins A

1. Synthesis of cortistatins A Wang Pusheng，2011/9/24

2. In 2006, Kobayashi and colleagues reported the isolation, biological evaluation, and structure determination of cortistatin A, a unique marine natural product with potent antiangiogenic activity(作用于人体血管壁细胞). Baran, P. S., J. Am. Chem. Soc. 130, 7241–7243 (2008) Nicolaou, K. C., Angew. Chem. Int. Ed. 47, 7310–7313 (2008) Shair, M. D., J. Am. Chem. Soc. 130, 16864–16866 (2008)

3. Baran, P. S., J. Am. Chem. Soc. 130, 7241–7243 (2008) Retrosynthetic strategy

4. TBAA: Tetra-n-butylammonium acetate Mukaiyama hydration

6. Nicolaou, K. C., Angew. Chem. Int. Ed. 47, 7310–7313 (2008) Retrosynthetic strategy

7. Ohira–Bestmann reagent

10. Shair, M. D., J. Am. Chem. Soc. 130, 16864–16866 (2008) Retrosynthetic strategy

13. More strategy

14. Mukaiyama hydration Isayama, S.; Mukaiyama, T. Chem. Lett. 1989, 1071–1074. back

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17. Barton, D. H. R.; O’Brien, R. E.; Sternhell, S. J. Chem. Soc. 1962, 470-476. back

18. Ohira–Bestmann reagent back

19. IBX-MediatedDithiane Deprotection back

20. Oxidation of Silyl Enol Ethers by Using IBX.N-Oxide Complexes back

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