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J. E. Handsaker 1 Supervisor Professor G. Medley 1

Statistical analysis of natural and maternally derived antibody responses in respiratory syncytial virus. J. E. Handsaker 1 Supervisor Professor G. Medley 1.

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J. E. Handsaker 1 Supervisor Professor G. Medley 1

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  1. Statistical analysis of natural and maternally derived antibody responses in respiratory syncytial virus J. E. Handsaker1 Supervisor Professor G. Medley1 Respiratory syncytial virus (RSV) is a major cause of infant hospitalisation across the globe. The purpose of this study was the use of immunological data to find a protective antibody level using statistical analysis in MatLab. METHODS Cohort data from a study conducted between 2002-2005 in the Kilifi district of Kenya was analysed. ELISA antibody titres were interpolated and extrapolated. A case-control study was conducted, and the risk of infection, Ri, was determined. The risk of infection was plotted against antibody titre to see of a correlation could be seen. CONCLUSIONS No correlation between Ri and antibody titre was seen, indicating no correlation between the antibody levels in serum and the risk of infection to a child. However, interesting decay of maternally-derived antibody was observed. The experiment could have been stronger had the results not been based on interpolation and extrapolation; these could have been avoided had nasal washings to check for infection been collected on the same day as antibody titre measurements. Furthermore, the use of ELISA titres does not lend itself well to this type of analysis, as it shows only the antigen-binding antibody levels in serum, not necessarily antigen-neutralising, 1School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7ES

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