THE KREB’S CYCLE
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THE KREB’S CYCLE What Goes Around Comes Around. The Krebs Cycle What Goes Around Comes Around. Part 1: Preparation of Pyruvate. Mitochondria Outer Membrane. Cytosol. Mitochondria. NAD+. NADH. (2C) Acetic Acid. H. CO 2. Coenzyme A. Acetyl – Coenzyme A. Pyruvate (3C).

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THE KREB’S CYCLE What Goes Around Comes Around

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The kreb s cycle what goes around comes around

THE KREB’S CYCLE

What Goes Around Comes Around


The kreb s cycle what goes around comes around

The Krebs Cycle What Goes Around Comes Around

Part 1: Preparation of Pyruvate

Mitochondria Outer Membrane

Cytosol

Mitochondria

NAD+

NADH

(2C)

Acetic Acid

H

CO2

Coenzyme A

Acetyl – Coenzyme A

Pyruvate (3C)

Transport Protein


The kreb s cycle what goes around comes around

Acetyl CoA

Part 2: Kreb’s Cycle

(2C)

CoEnzyme A

NADH

H2O

NAD+

Oxaloacetate (4C)

Malate

(4C)

Citrate (6C)

Isocitrate (6C)

CO2

THE KREB’S CYCLE

NAD+

H2O

NADH

CoEnzyme A

Fumarate

(4C)

CoEnzyme A

a-Ketoglutarate (5C)

FADH

FAD+

NAD+

CO2

TOTALS

Succinate

(4C)

GTP

GDP

NADH

ATP =

1 X 2 = 2

Succinyl- CoA

(4C)

NADH =

4 X 2 = 8

ADP

FADH =

1 X 2 = 2

ATP

CO2 =

3 X 2 = 6

Kreb’s Cycle Song


The kreb s cycle what goes around comes around

Slide 2


The kreb s cycle what goes around comes around

The Krebs Cycle

melody and lyrics by Lynda Jones; adapted by Do Peterson and Greg Crowthe

Greg: geek vocals, keyboard Lori: lead vocals Kirk L. Van Scoyoc: banjo

Do: bass, hyper-dramatic vocals, keyboard, acoustic and electric guitar, drum

Acetyl CoA combines with oxaloacetic acid

To create a citric acid. That's how it begins.

Then a water removed and added makes it isocitric acid,

Which, in turn, oxidized and loses CO2.

Then alpha-ketoglutaric is oxidized again,

Losing carbon dioxide with an NADH spin.

Then through a phosphorylation

Succinyl CoA congeals a GDP to GTP to toss back CoASH.

CHORUS:Acetyl CoA, citric acid, iso-,Alpha-ketoglutaric, succinyl CoA,Succeeded by succinic, fumaric and malic,Then oxaloacetic starts the cycle again.

CHORUS

Soon we see succinic acid forming a fumaric acid

As it forms an FADH2 along the way.

Water washed upon fumaric makes it into acid malic.

Now there's only one step left, so let's be on our way.

With one more oxidation, resisting degradation,

A final NADH is made and brings us to the end.

Oxaloacetic acid, first and last, a simple acid

Then accepts an acetyl CoA and starts again.


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