Ethanol
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Ethanol. Ethanol Acetaldehyde PEth ROS Others. RTK. GPCR/ G-proteins. Src. Acetaldehyde. Ras-raf. PKC. PEth. ROS , others. MEK 1/2. Acetate. p38 MAPK. p42/44 MAPK. JNK1/2. Caspases. ?. p42/44 MAPK. JNK1/2. p38 MAPK. MSK 1/2. Histone/chromatin modification

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Ethanol

Ethanol

Acetaldehyde

PEth

ROS

Others

RTK

GPCR/ G-proteins

Src

Acetaldehyde

Ras-raf

PKC

PEth

ROS , others

MEK 1/2

Acetate

p38 MAPK

p42/44 MAPK

JNK1/2

Caspases

?

p42/44MAPK

JNK1/2

p38 MAPK

MSK 1/2

Histone/chromatin modification

(acetylation, phosphorylation etc.)

Transcription factor/activation

(NFkB, AP1, CREB etc.)

NUCLEUS

Apoptosis Inflammation Proliferation Differentiation


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