Neonatal Jaundice By Dr. Nahed Al-Nagger. Neonatal Jaundice. Learning Objectives: Define hyperbilirubinemia. Differentiate between physiological and pathological jaundice. State causes of hyperbilirubinemia. Discuss the pathophysiology of hyperbilirubinemia.
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Hb → globin + haem
1g Hb = 34mg bilirubin
Non – heme source
1 mg / kg
(Y - acceptor)
Bilirubin Production & Metabolism
Area of body Bilirubin levels mg/dl(*17=umol)
Upper trunk 5-12
Lower trunk & thighs 8-16
Arms and lower legs 11-18
Palms & soles > 15
Note: Baby should, however, be watched for worsening jaundice.
1 2 3 4 5 6 10 11 12 13 14
Age in Days
Course of physiological jaundice
Appearing within 24 hours of age
Appearing between 24-72 hours of life
After 72 hours of age
Baby under conventional phototherapy
Baby under triple unit intense phototherapy
jaundice at regular intervals.
the first week of life and
may be missed in dark skinned
Blanching the tip
of the nose
*Lethargy and poor feeding, poor or absent Moro's, or convulsions