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Lecture 10 – Second Messengers IV – Niric Oxide, cGMP , and ROS Signalling. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. CSB Fig 02:01 Cell signalling pathways .

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lecture 10 second messengers iv niric oxide cgmp and ros signalling

Lecture 10 – Second Messengers IV –Niric Oxide, cGMP, and ROS Signalling

BIOL 5190/6190 Cellular & Molecular Singal Transduction

Prepared by Bob Locy

Last modified -13F

slide2

CSB Fig 02:01 Cell signalling pathways

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

transducers second messengers ii
Transducers Second Messengers II
  • Nitric Oxide
    • cyclic GMP Signaling
  • Redox signaling
  • ROS signaling
slide4

CSB Fig 2:45 NO and cyclic GMP signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide5

CSB Fig 2:46 NO synthase mechanism

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide6

CSB Fig 2:47 eNOS activation

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide7

CSB Fig 2:48 Summary of redox signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide8

CSB Fig 2:49 Reactive oxygen species (ROS)

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide9

CSB Fig 2:50 Sites of ROS formation

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide10

CSB Fig 2:51 Plasma membrane ROS formation

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide11

CSB Fig 2:52 GSH/GSSG couple

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide12

CSB Fig 2:53 H2O2 metabolism

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide13

CSB Fig 2:54 Peroxiredoxin catalytic cycles

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide14

CSB Fig 2:55 Reversible & irreversible ROS oxidations

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide15

CSB Fig 2:56 ROS formation and action

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide16

CSB Fig 2:57 Recovery of protein oxidation

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide17

CSB Fig 2:58 Thimerosal-induced Ca2+ signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide18

Module 2:59 Figure ROS effects on Ca2+ signalling

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide19

CSB Fig 2:60 ROS microdomains

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

slide20

CSB Fig 2:61 ROS microdomains

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

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