Improving Free Energy Functions for RNA Folding. RNA Secondary Structure Prediction. Why RNA is Important. Machinery of protein construction Catalytic role in cells May be possible to destroy specific sequences of RNA (to interrupt protein production) RNase P (Cech/Altman c.1981).
RNA Secondary Structure Prediction
SecondaryRNA Structural Levels
Zuker (1981) Nucleic Acids Research 9(1) 133-149
Hofacker et al. (1994) Monat. Chem. 125 167-188
See proposal for references
The free energy of a secondary structure equals the sum of the free energies of the loops and stacked pairs
Tinoco et al. (1971) Nature 230 362-367.
(23 52 3 3.2)
weightGenetic Algorithm - Repn.
Placement must be conflict free.
C2Genetic Algorithm - Operators