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بنام خداي زيبائيها

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بنام خداي زيبائيها. Major Histocompatibility complex OR. MHC. MHC. The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) peptide recognition by T and B cells is different.

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Presentation Transcript
slide3
MHC
  • The principal function of T cells are :

Defense against intracellular microbes

Activation of other cells(B cells ,Macrophages )

  • peptide recognition by T and B cells is different.

B cells recognize soluble as well as cell associated Ags

In contrast ,T cells recognize peptide which is displaying only by APC in associated with MHC proteins.

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MHC
  • MHC genes are the most polymorphic genes
  • MHC genes are codominantly expressed in each individual
  • There are two main type of MHC:class I & II
  • The physiologic function of MHC molecules is presentation of peptides to T cells ,control of immune responsiveness to all proteins and graft rejection
  • MHC-I present cytosolic peptides to T cytotoxic cells and MHC-II present endocytosed peptides to Thcells
polymorphism of class ii
Polymorphism of class II
  • HLA-DPA 12
  • HLA-DPB 88
  • HLA-DQA 17
  • HLA-DQB 42
  • HLA-DR >400
polymorphism of class i
Polymorphism of class I
  • HLA-A >280
  • HLA-B >500
  • HLA-C >130
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