Water, pH and Biological Molecules
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Water, pH and Biological Molecules. What’s so special about water?. It’s a great solvent. It hold’s tons of heat. It has high surface tension. Its less dense as a solid than a liquid. Water as a Solvent. Dissolving table salt (sodium chloride).

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Water, pH and Biological Molecules

What’s so special about water?

It’s a great solvent.

It hold’s tons of heat.

It has high surface tension.

Its less dense as a solid than a liquid.


Water as a Solvent

Dissolving table salt (sodium chloride)


This means that ice forms an insulating blanket over water.

Water Is Lighter as Solid than as a Liquid


Water Has High Surface Tension

The attraction of one water molecule for another also accounts for ability to hold huge amounts of heat.


pH is a Big Deal

pH is a measure of proton (hydrogen ion or H+) concentration .

Low pH = lots of H+s, high pH = few H+s.

In biology, keeping H+ levels within a narrow range is critically important.


An acid produces H+

A base absorbs H+

Acids and Bases


Carbon’s Cool

Carbon is the central atom of life.

Because carbon contains 4 electrons in its outer shell, it can pair in many ways with many different atoms in an “attempt” to fill its outer shell.


glucose

amino acids

fat

Carbon is the Central Atom of Life.



In Biology, Shape Matters

Its not just chemical formula, it’s the shape of the molecule that lets it do its “job”.

Never forget the axiom – structure dictates function.

Some biological molecules.


Ah, That Smell!

Once again, shape matters. It’s the good fit between odorant and receptor molecule that lets us detect aromas.


Four Major Classes of Biological Molecules

Molecules of Life

How do you build a cell?

Start with water, add lots of small carbon-containing molecules and …….


Rules of the Game

Macromolecules are built by linking a set of building blocks (monomers) together into long chains (a polymer).

Each hexagon is this figure is a monomeric building block linked together to form a polymer.


Macromolecules Are Built By Linking a Set Of Building Blocks (Monomers) Together Into Long Chains (A Polymer).


Glucose: A Simple Carbohydrate Used For Energy Production and as a Building Block For Complex Carbohydrates


Linking Simple Sugars – the First Step to a Polymer and the Last Step to Some Familiar Compounds


Some Familiar and Important Complex Carbohydrates the Last Step to Some Familiar Compounds

Note the way complex macromolecule are built by linking simple repeating units.



Sterol Storage

Phospholipid

Fat

Lipids are Hydrophobic Molecules That Exist In Three Primary Forms


Space-filling model of a fat Storage

A fatty acid

Fats Are Made By Linking Fatty Acid Chains to Glycerol, a Three Carbon Molecule



Where are the double bonds? Storage

The Degree Of Saturation In A Fat Affects Its Physical And Nutritional Properties


saturated Storage

monounsaturated

Where are the double bonds?

polyunsaturated

The Degree Of Saturation In A Fat Affects Its Physical And Nutritional Properties


Note the four ring structure common to all sterols. Storage

Sterols Are Part of Cellular Membranes and Act as Hormones


Sterols As Hormones Storage

Estrogen, testosterone, progesterone, and corticosteriods (cortisol) are all steroid hormones.


A heavily muscled Linford Christie who was disqualified from international competition after testing positive for a banned steroid.

Sterols As Hormones

“Designer steroids” are major sporting news where they have been used illegally in track and field, baseball, football and countless other sports.


Phospholipids are Building Blocks of Cellular Membranes international competition after testing positive for a banned steroid.

The hydrophilic head group and hydrophobic tails are the keys to phospholipid function.


Hydrophilic Head Group And Hydrophobic Tails Are The Keys To Phospholipid Function

Phospholipids have a Jekyll and Hyde personality.



Protein Phospholipid Function

Proteins are THE key elements of life. Forget DNA, proteins rule.

Remember the principle - structure determines function.

Since proteins are the key players of the cell, it follows that protein structure determines cell function.






Peptide bonds Phospholipid Function

Amino Acids, Peptide Bonds, Polypeptides, Protein

Proteins are linear chains of 20 different building blocks called amino acids.

Amino acids are linked by peptide bonds – a form of covalent bond.


Proteins are Folded Structures Whose Shape (and therefore function) Depends on Amino Acid Sequence


Nucleic Acids function) Depends on Amino Acid Sequence

There are two kinds of nucleic acids, DNA and RNA. Both are involved in the storage and flow of information from gene to gene product.

DNA


Nucleotides are DNA and RNA Building Blocks function) Depends on Amino Acid Sequence


ATP, the cell’s primary energy currency. function) Depends on Amino Acid Sequence

Nucleotides are Important in Their Own Right

Nucleotides fuel the cell and coordinate its metabolism.


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