How Biorepositories Can Help Your Research. Tatiana Foroud, Ph.D. Department of Medical and Molecular Genetics. Overview. Sample collection for genetic studies Typical DNA applications for genetic studies Results from several ongoing studies. Collecting Samples for Genetic Studies.
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How Biorepositories Can Help Your Research
Tatiana Foroud, Ph.D.
Department of Medical
and Molecular Genetics
107 SNPs analyzed
Alcohol dependence and the ADH Gene cluster
Adapted from Howard Edenberg
Modified from Edenberg et al, 2006
Co-Principal Investigators: B. Porjesz, V. Hesselbrock, H. Edenberg, L. Bierut
Nine centers where data collection, analysis and storage take place:
Univ. of Connecticut V. Hesselbrock
Indiana UniversityH. Edenberg, J. Nurnberger, PM Conneally, T. Foroud
University of IowaS. Kuperman, R. Crowe
SUNY HSC @ BrooklynB. Porjesz
Washington UniversityL. Bierut, A. Goate, J. Rice
Univ. of Calif. (UCSD)M. Schuckit
Howard UniversityR. Taylor
Rutgers UniversityJ. Tischfield
Southwest Foundation L. Almasy
NIAAA Staff Collaborator: M. Guo
This national collaborative study is supported by the NIH Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). In memory of Henri Begleiter and Theodore Reich, Principal and Co-Principal Investigators of COGA since its inception. We are indebted to their leadership in the establishment and nurturing of COGA, and acknowledge with great admiration their seminal scientific contributions to the field.
Bloomington: Genome Sequencer FLX (GS FLX)
Purdue: SOLiD Analyzer
National Cell Repository for Alzheimer Disease
NIA funded resource to make DNA and associated clinical material available to qualified researchers
Genome Wide Association Studies
DNA inherited in blocks, so not all 10 million SNPs have to be tested
Genotype several hundred thousand SNPs
Compare frequency of SNP alleles in two groups
Compare frequency of SNP genotypes in two groups
Increased number of copies in some samples
Data from 270 HapMap Samples on Chromosome 11
Genome Wide Association Study in Familial Parkinson Disease
CEPH families are all in the main cluster
Pankratz & Wilk et al., 2008
Nathan Pankratz, Ph.D.
Bernardino Ghetti, M.D.
Cheryl Halter, M.S., CCRC
Claire Wegel, M.S.
Cincinnati Children’s Hosp.
William C. Nichols, Ph.D.
Veronika E. Elsaesser
Diane K. Marek
Univ. of Tennessee
Ronald Pfeiffer, M.D.
University of Rochester
Alice Rudolph, Ph.D.
PSG Investigators & Coordinators
Supported by NS37167