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Is Perk involved in the PPAR alpha adaptive response to fasting in the liver?

Is Perk involved in the PPAR alpha adaptive response to fasting in the liver?. Part II. “Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting” by Kersten, et al.~ Journal of Clinical Investigation, June 1999.

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Is Perk involved in the PPAR alpha adaptive response to fasting in the liver?

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  1. Is Perk involved in the PPAR alpha adaptive response to fasting in the liver? Part II “Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting” by Kersten, et al.~ Journal of Clinical Investigation, June 1999 PPAR alpha = known regulator of oxidation in the liver: *Fasted PPARα-null mice -have significantly higher Free Fatty Acids -have a fatty liver -become hypoglycemic -have significantly decreased levels of β-hydroxybutyrate

  2. Liver Blood

  3. Albumin-Cre Mice (Liver specific KO ~ 3 months old)

  4. Free Fatty Acids in PPARalpha null mice vs Albumin-Cre KO mice

  5. KO Fast KO Fed WT Fast WT Fed

  6. KO Fast WT Fast PPAR alpha mice

  7. Conclusions: • Fasted Perk Liver Specific KO Mice • -have a somewhat fatty liver (significantly different than Fasted WT?) • -do NOT become hypoglycemic • -do NOT have significantly decreased levels of β-hydroxybutyrate • -do NOT have significantly higher Free Fatty Acids • Do not seem to be directly involved in the PPAR alpha adaptive response to fasting in the liver THANKS FOR ALL YOUR HELP!!! Kaori, Sounak, Vivian

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