Lecture: 1. Immunology (elective) MLIM-101. Prepared by: Dr. Mohamed S. Abdel- Latif. INNATE ( NON-SPECIFIC ) IMMUNITY. Learning Outcome:. At this time you should know the following: 1. Differences between the non-specific and specific immune functions.
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Dr. Mohamed S. Abdel-Latif
INNATE ( NON-SPECIFIC ) IMMUNITY
At this time you should know the following:
1. Differences between the non-specific and specific immune functions.
2. Humoral components of the non-specific immune system and their action.
3. Cellular components of the non-specific immune function and their action.
4. Pathways of intracellular killing of bacteria by phagocytes and their characteristic features.
5. Effect of humoral components such as interferon, TNF, IL-2, complement etc. on cellular components of the non-specific immune system.
"When the mind is ready,a teacher appears.“
Cells of the Immune System
complement, interferon, TNF etc.
T cells; other effectors cells
Components of the Immune System
Bolus of infection x virulence
No time lag
A lag period
Not antigen specific
skin, gut Villi, lung cilia,etc
many protein and
phagocytes, NK cell eosinophils, K cells
T and B lymphocytes
flushing, fatty acids
Peristalsis, low pH
bile salts, fatty acids
Effector mechanisms in Innate Immunity -1
Effector mechanisms in Innate Immunity -2
mucus, saliva, tears
phagocytosis and intracellular killing
K, NK & LAK cells
direct and antibody dependent cytolysis
Effector mechanisms in Innate Immunity -3
Serum and other serous fluids
antiviral proteins phagocyte activation
opsonization, enhanced phagocytosis, inflammation
Fibronectin & complement
George Bernard Shaw wrote:
“There is at bottom only one genuine treatment for all diseases,…to stimulate the phagocytes. Drugs are a delusion. …(when) the phagocytes are stimulated; they devour the disease…”
the work of
azurophilic; characteristic of young neutrophils;
specific for mature neutrophils
contain cationic proteins, lysozyme, defensins, proteases and
contain lysozyme, NADPH oxidase, lactoferrinand B12-binding protein
NADPH + O2
2O2- + 2H+
H2O2 + 1O2
2O2- + H2O2
.OH + OH- + 1O2
Oxygen Dependent Myeloperoxidase Independent Reactions
H2 O2 + Cl-
OCl- + H2O
2OCL- + H2O
2O2- + 2H+
H2O2 + O2-
2 H2 O2
H2O + O2-
Oxygen Dependent Myeloperoxidase dependent reactions
Cationic proteins (cathepsin)
Damage to microbial membranes
Hydrolyses mucopeptides in the cell wall
Deprives pathogens of iron
Hydrolytic enzymes (proteases)
Digests killed organisms
NK and LAK cells
ADCC (K) cell
They all kill foreign and altered self targets
also known as large granular lymphocytes (LGL)
kill infected and malignant cells
are identified by the presence of CD56 & CD16 and absence of CD3
activated by IL2 and IFN-γto become LAK cells
kills malignant cells
kills transformed and malignant cells
As a part of the semester activity, group of students is selected every week to prepare a short seminar about his/her point of interest in one of the lecture topics. That to be discussed and evaluated during the next lecture.