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Serosurveillance for monitoring immunization coverage in DHS July 24, 2015 Bernard Barrère

Serosurveillance for monitoring immunization coverage in DHS July 24, 2015 Bernard Barrère. Madagascar DHS 2003-04: Overview. SAMPLE and BIOMARKERS National sample of 8,400 households

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Serosurveillance for monitoring immunization coverage in DHS July 24, 2015 Bernard Barrère

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  1. Serosurveillance for monitoring immunization coverage in DHS July 24, 2015 Bernard Barrère

  2. Madagascar DHS 2003-04: Overview • SAMPLE and BIOMARKERS • National sample of 8,400 households • In all households: anthropometric measurements and hemoglobin testing among women age 15-49 and children < 5 • In 1/3 households: syphilis testing among all women age 15-49 and men age 15-59 • In 1/3 households: testing for immunity to tetanus among women and children <5, and immunity (or exposure) to measles among children <5 • Measles/Tetanus testing was entirely part of the DHS • Blood samples were collected by the DHS teams • Testing in the labs was done according to a protocol developed with and approved by DHS • Results were analyzed in collaboration with the labs and reported in the Madagascar DHS report

  3. Madagascar DHS 2003-04: Methodology Capillary blood from finger prick was collected on filter paper (DBS) • One DBS was sent to the Pasteur Institute in Antananarivo for measles testing • One DBS was sent to the Baxter Health Care Lab (MD, USA) for tetanus testing COVERAGE FOR TETANUS/MEASLES TESTING Blood samples were collected and tested for: • 91% of 2,817 eligible women • 86% of 1,917 eligible children

  4. Madagascar DHS 2003-04: Example of Results

  5. DR Congo DHS 2013-14: Overview (1) SAMPLE and BIOMARKERS • National sample of 18,171 households. • In all households: anthropometric measurements of women age 15-49 and children < 5 In 1/2 households: • Anemia testing among women age 15-49, men age 15-59, and children age 6-59 months • HIV testing women age 15-49 and men age 15-59 • Malaria testing (RDT and thick smear) among children age 6-59 months • DBS collected from children 6-59 months for PCR test for diagnosis of malaria and for immunity to Tetanus, Rubella, Measles, Mumps, Polio and Varicella.

  6. Immunity testing was not entirely part of the DHS • Blood samples were collected by the DHS teams • DHS developed programs to log-in the DBS and record the test results, and merged the testing data and survey data • But testing in the labs was done independently without any involvement of DHS • Initially basic test results were supposed to be reported in the DRC-DHS report released in September 2014. No result was available at that time. DR Congo DHS 2013-14: Overview (2)

  7. DR Congo DHS 2013-14: Methodology Capillary blood from finger prick was collected on filter paper (DBS) The filter papers were sent to UCLA-DRC laboratory at the National Laboratory for Biomedical Research (INRB) in Kinshasa, were they were logged in and divided in three: • One DBS remained at the UCLA/INRB lab in Kinshasa for Measles, Mumps, Rubella, Varicella, and Tetanus testing • One was sent to CDC Atlanta for polio testing • COVERAGE FOR TESTING AT UCLA/INRB LAB • Blood samples were collected and tested for • 95.4% of 8,420 eligible children age 6-59 months

  8. DR Congo DHS 2013-14: Example of Results

  9. On-going survey As part of the on-going Mozambique HIV/Malaria survey, DBS are collected from children age 6-59 months for Tetanus and Hep B testing

  10. Madagascar DHS 2003-04: Example of Results (3)

  11. Madagascar DHS 2003-04: Example of Results (2)

  12. DR Congo DHS 2013-14: Example of Results (1)

  13. DR Congo DHS 2013-14: Example of Results (3)

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