Theme 1 improving the experimentation and discovery process
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THEME 1: Improving the Experimentation and Discovery Process. Unprecedented complexity of scientific enterprise Is science stymied by the human bottleneck?. The Research Process – cyclic . Support for designing the experiment (or study) Identify controls Inventory materials/equipment

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Theme 1 improving the experimentation and discovery process

THEME 1: Improving the Experimentation and Discovery Process

Unprecedented complexity of scientific enterprise

Is science stymied by the human bottleneck?


The research process cyclic
The Research Process – cyclic

  • Support for designing the experiment (or study)

    • Identify controls

    • Inventory materials/equipment

    • Protocols

    • Statistics, comp tools

  • Support for executing the experiment (or study)

    • Get funding

    • Adaptive /real time experimentation

    • Integrative interpretation

  • Analyzing/exploring/validate the data

  • Interpreting the results

    • Collaborative analysis

  • Putting the results in context

  • Communicating and

  • Prioritizing the next thing

    • Make assumptions through background knowledge (combination of existing knowledge) via

      • Literature

      • Data

      • Collaboration

    • Internalization -> idea(s)

    • Consider the importance/novelty/feasibility/cost/risk of the idea(s)

    • Formulate testable hypothesis(s)

    • Make consistent/validate with/against existing knowledge


    To advance understanding about a biological system, the usual starting point is the hypothesis, or model, constructed and refined using available information about the biological system. Refined hypotheses are subjected to experimental testing and hypotheses that survive this validation are shared, generally through publication.

    Making Biological Computing Smarter - The Scientist - Magazine of the Life Sciences http://www.the-scientist.com/article/display/15508/#ixzz1lGQM6R41


    Global needs
    Global Needs usual starting point is the hypothesis, or model, constructed and refined using available information about the biological system. Refined hypotheses are subjected to experimental testing and hypotheses that survive this validation are shared, generally through publication.

    • Appropriate metadata at all stages of the process

    • Usability, Accessibility, Reproducibility

    • Collaboration – developers and consumers must both be engaged in the process.

      • Form a community around the process

      • Characterize the community and the explicit process

      • Need scalable/generalizable tools and specialized tools that map to explicit processes

    • Formal representation of the knowledge linked to the data and metadata

    • Value metrics/reward system

    • Getting a better grasp on what has succeeded and what has failed

      • What has worked and what has not

      • Education regarding usability, human computer interaction

    • Improved methods for abductive inference


    Kr and computation complexity
    KR and computation complexity usual starting point is the hypothesis, or model, constructed and refined using available information about the biological system. Refined hypotheses are subjected to experimental testing and hypotheses that survive this validation are shared, generally through publication.

    High KR complexity

    Minimal KR complexity

    Minimal computational complexity

    High computational complexity


    Actions
    Actions usual starting point is the hypothesis, or model, constructed and refined using available information about the biological system. Refined hypotheses are subjected to experimental testing and hypotheses that survive this validation are shared, generally through publication.

    • Make assumptions through background knowledge (combination of existing knowledge) via

      • Literature

      • Data

      • Collaboration

      • Social media

    • Find a knowledge association

    • Mendeley

    • Assimilation of information (eg neuroscience information framework)

    • More sophisticated methods for assessing a search result

    • Filtering of social media


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