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Does Stress Really Impair Memory?

Does Stress Really Impair Memory?. Student’s Name ： 顏嘉賢 School Number ： B9802033. QUESTION. How is stress related to memory? Enhance? Impair? Why?. INFORMATION 1: ENHANCEMENT OF MEMORY. Stressful / emotionally arousing events enhance the “consolidation” of memory Stress hormones

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Does Stress Really Impair Memory?

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  1. Does Stress Really Impair Memory? Student’s Name：顏嘉賢 School Number：B9802033

  2. QUESTION • How is stress related to memory? • Enhance? • Impair? • Why?

  3. INFORMATION 1: ENHANCEMENT OF MEMORY • Stressful / emotionally arousing events • enhance the “consolidation” of memory • Stress hormones • stress-activated neurotransmitters • Amygdala

  4. INFORMATION 2: STRESS HORMONES • Glucocorticoids • Cortisol • Stress cortisol receptor • Long-term exposure to cortisol atrophy of hippocampus naturally (In hippocampus)

  5. Dendritic Spine • Learning & memory • Synapses

  6. synapse

  7. INFORMATION 3: CRH &CRHR • CRH: corticotropin releasing hormone • Secreted by hypothalamus • CRHR: CRH receptor • Located in hippocampus

  8. “consolidation” Acute Stress CRH release hippocampus dendritic spines disintegration CRHR impair memory storage collection

  9. On the contrary… CRH CRHR BLOCK damage eliminated binding

  10. INFORAMTION 4: REVERSIBILITY • From Newcomer’s experiment: • Memory impairment is reversible • “the point of no return” • Controlling cortisol levels pharmacologically

  11. THE SAME QUESTION • How is stress related to memory? • Enhance? • Impair?

  12. THE ANSWER~~~~~ BOTH !!!! However…

  13. CONCLUSION • Stress itself is not harmful… but the EXCESS of stress is!!! • Acute or chronic exposure to stress causes functional and morphological alterations in the brain impair memory consolidation

  14. Thanks for your attention!

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