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Tx studygroup 2. Karlien, Ann, Tonny, Jaap & Nikki. Goals. To formulate research questions To discuss the Tx treatment policies. Tx data. 138 Tx in 135 children Outflow: (20 to adult care, 1 died, 1 pre Tx failure) Current therapy HD: 5 PD: 1 Tx: 107. Rejection. Tx failure.

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tx studygroup 2

Tx studygroup 2

Karlien, Ann, Tonny, Jaap & Nikki

goals
Goals
  • To formulate research questions
  • To discuss the Tx treatment policies
tx data
Tx data

138 Tx in 135 children

Outflow: (20 to adult care, 1 died, 1 pre Tx failure)

Current therapy

HD: 5

PD: 1

Tx: 107

tx failure
Tx failure
  • N=7
  • M0: 4 (reasons missing)
  • M3: 2 (1x vasc rejection, 1xmissing)
  • M24: 1 (chronic rejection)
research proposals
Research Proposals

1. Pharmacokinetics/immigrants – Karlien

2. Infections after tx

  • prevalence and association tx failure BK viremia
    • Policies with regard to immunosuppression/therapy
    • Course
    • Addition data from German centres (?)
  • prevalence CMV infection:
    • Influence aciclovir prophylaxisi on disease activity
    • Influence donor/recipient +/-

3. MBL- polymorphism

research proposals1
Research Proposals
  • Tx + MBL deficiency:
    • Favour (bacterial) infection? (de Rooij ea)
    • less renal damage in ischemia-reperfusion?
  • Aim; association between MBL-polymorphism + MBL activity vs.
    • Time to reach lowest s-creatinine post tx
    • Number of bacterial infections with fever
    • Number of rejections
  • Genotype
  • MASP + MBL-MASP complex d 1 tx + 1/6m
farmacokinetiek genetica
Farmacokinetiek/-genetica
  • Immigranten hebben meer acute rejecties, waarom?
  • (zou onafhankelijk van donorbron zijn)
  • Zelfde immsupp behandeling? (RichQ)
  • Zelfde geschatte therapietrouw? (RichQ)
aanvullende methoden
Aanvullende Methoden
  • Selectie uit onderzoek: alle patienten die TCL gebruiken, trpl > 1,5 jaar geleden
  • C0 en variabiliteit tussen mnd 6 en mnd 18
  • C0/relatieve dosis (mg/kg.dag)
  • Farmacogenetica CYP3a4, 3a5, ABCB polymorfismes uit spijtbloed
management policies
Management policies
  • In 2007 management policies
  • Treatment policies dialysis accepted by NDT
  • NDT: Also transplantation data?
management policies tx
Management policies Tx
  • More detailed questionnaire of Tx management policies
  • Compared to literature
  • Compared to RICH-Q data
management policies topics
Management policies topics
  • Pre Tx

(screening, medication, ….)

  • Tx

(donor, medication, ….)

  • Post Tx

(medication, follow up)

please
Please….
  • Send me the management policies Tx
  • Send a copy of all your protocols concerning transplantation to [email protected]

>>Publication

new tx form
New Tx form

Changes?

Variables to add?

>> Please let us know a.s.a.p.

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