Substitution and Elimination. Reactions of Alkyl Halides. Substitution, Nucleophilic, Bimolecular – S N 2. Reaction Profile for S N 2 Reaction (Wade). Stereochemistry of S N 2 Reaction Inversion of Configuration. Proof of Inversion of Configuration at a Chiral Center.
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Reactions of Alkyl Halides
Since the energy of the transition state is significant in determining the rate of the reaction, a primary substrate will react more rapidly than secondary (which is much more rapid than tertiary).