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Retroviral Life Cycle: Latent vs. Active infection PowerPoint PPT Presentation


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In latent infection- retroviral genome is present but is not transcribing viral genome or mRNA for structural proteins. Distinguished by qPCR (DNA) and qRT-PCR (RNA). Retroviral Life Cycle: Latent vs. Active infection .

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Retroviral Life Cycle: Latent vs. Active infection

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Retroviral life cycle latent vs active infection l.jpg

In latent infection- retroviral genome is present but is not transcribing viral genome or mRNA for structural proteins.

Distinguished by qPCR (DNA) and qRT-PCR (RNA)

Retroviral Life Cycle:Latent vs. Active infection

In latent infection- retroviral genome is present but is not transcribing viral genome or mRNA for structural proteins.

Distinguished by qPCR (DNA) and qRT-PCR (RNA)


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Not a mouse contaminant

XMRV is a new human retrovirus

Not prostate cancer XMRV

Phylogenetic analysis revealed that XMRV isolates from prostate cancer and CFS form a distinct branch within non ecotronic MLVs

  • Not a mouse contaminant

  • XMRV is a new human retrovirus

  • Not prostate cancer XMRV


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University Of Nevada, Reno Cleveland Clinic – Bob Silverman and Javdip Das Gupta

Vincent Lombardi

Judy Mikovits

DanielPeterson

Kathryn Hagen

Max Pfost

National Cancer Institute

Sandra Ruscetti

Frank Ruscetti

Rachel Bagni

Cari Petrow-Sadowski

Bert Gold

Michael Dean

Detection of Infectious Xenotropic MuLV-Related Virus (XMRV)in Blood Cells From Patients With Chronic Fatigue Syndrome

University of Nevada, Reno

Vincent Lombardi

Judy Mikovits

DanielPeterson

Kathryn Hagen

Max Pfost

Sandra Ruscetti

Frank Ruscetti

Rachel Bagni

Cari Petrow-Sadowski

Bert Gold

Michael Dean

Bob Silverman

Jaydip Das Gupta


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CFS Study Cohort Reported in Science:

Study cohort from the WPI national repository.

Repository samples include samples from NV, CA, OR, FL, NC and NY as well as international CFS patients.

Repository inclusion criteria:

CFS diagnosis, regardless of severity

19-75 years of age

Study characteristic:

67% women, reflecting gender incidence of CFS

Mean age: 55

320 control samples from same geographic locations


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Questions

What cell types are infected?

How is XMRV transmitted?

Do infected individuals make an immune response?

What are the interactions between XMRV and the innate immune system?

Does XMRV infection alter the risk of cancer development in CFS?

Can we develop immune based therapies for CFS based on XMRV?


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