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POINT-OF-CARE TEST FOR DIAGNOSIS OF CELIAC DISEASE

POINT-OF-CARE TEST FOR DIAGNOSIS OF CELIAC DISEASE. Workshop MEDICEL The Mediterranean Network for Celiac Disease III Progress Meeting PastaTrend, BolognaFiere Bologna, April 5 th 2011. Celiac disease: diagnosis. POINT OF CARE TEST.

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POINT-OF-CARE TEST FOR DIAGNOSIS OF CELIAC DISEASE

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  1. POINT-OF-CARE TEST FOR DIAGNOSIS OF CELIAC DISEASE Workshop MEDICEL The Mediterranean Network for Celiac Disease III Progress Meeting PastaTrend, BolognaFiere Bologna, April 5th 2011

  2. Celiac disease: diagnosis POINT OF CARE TEST • Celiacautoantibodies can bedetectedwith a simpleIgAself-tGantibodies • Contrarytoconventionalserum EMA and tTG-abtests, self tTGrequired no externalpurified or recombinantceliacantigen(endogenouserythrocyte self tTG) • POCT isvery easy toperform, doesnotneedspecializedhealtcareprofessional • Result are available in 5 minutes

  3. Results (1) Positivityof the wholebloodrapid test, serumIgAendomysial antibody (EMA) and serumIgAtransglutaminase antibody (TG2-Ab) test in untreated coeliac disease patients and controls Coeliac disease case finding and diet monitoring by point-of-care testing I. R. Korponay-Szabo´ et al

  4. Results (2) Sensitivity, specificity, positive and negative predictive value and efficiency of the IgA-class rapid whole blood test, serumtissuetransglutaminase antibody (tTG-ab) and serumendomysium (EMA) tests on storedsamples in the laboratory. Comparison of on site rapid whole blood test results and serum endomysial antibody (EMA) and tissue transglutaminase antibody (tTG-ab) test results when patients under coeliac disease suspicion were investigated prospectively Self transglutaminase-based rapid coeliac disease antibody detection by a lateral flow method T. Raivio et al

  5. Celiac disease:Testsetting DIAGNOSIS DIAGNOSIS (suspected) ? MD MD Nurse POCT Hospital Laboratory test

  6. POINT OF CARE TEST: HOW (1) • Identifyperipheralvillageswith: • At least 5.000 inhabitants • Collaborative HealthCentre/GP/Nurse • Possibilitytostoreserum • Possibilitytocommunicatewith a referralcentre • Features of the patients to enlist: • Age: 1 year – 15 years • Growthdisorders and/or • Persistentdiarrhoea, vomiting, abdominaldiscomfort, anaemia and/or • Misery • Collect results in a logbook and send serum to a referral centre to confirm the diagnosis

  7. POINT OF CARE TEST: HOW (2)

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