Bioavailability
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Bioavailability Distribution Absorption and Transport PowerPoint PPT Presentation


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Bioavailability Distribution Absorption and Transport. Volume of Distribution. The volume of distribution is given by the following equation: Therefore the dose required to give a certain plasma concentration can be determined if the V D for that drug is known.

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Bioavailability Distribution Absorption and Transport

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Bioavailability distribution absorption and transport

Bioavailability

Distribution

Absorption and Transport


Bioavailability distribution absorption and transport

Volume of Distribution

The volume of distribution is given by the following equation:

Therefore the dose required to give a certain plasma concentration

can be determined if the VD for that drug is known.

The VD is not a physiologic value; it is more a reflection of how a drug

will distribute throughout the body depending

on several physicochemical properties, e.g. solubility, charge, size, etc.

VD is often calculated per weight of body – it is not volume any more!


Bioavailability distribution absorption and transport

VDProportion of Drug in body water

0.140%

0.1527%

1 4%

10 0.4%


Bioavailability distribution absorption and transport

Two compartment model

Blood

Tissue


Bioavailability distribution absorption and transport

Mode of entry of drugs/toxins

Skin transport

Respiratory route

Oral route


Bioavailability distribution absorption and transport

Organ pH Surface Area Time

Stomach1-3up to 5 m20.5-20 h

Small Intestine5-7200 m22 h

Colon7-8up to 52 h – 1 week

logC

Time


Bioavailability distribution absorption and transport

DrugBioavailability VD (L/kg weight)

Diazepam1000.5-2

Morphine15-603-5

Pentobarbital950.7-10

Tetrahydrocannabinol 69-11

VDProportion of Drug in body water

0.140%

0.1527%

1 4%

10 0.4%


Bioavailability distribution absorption and transport

Surface Area

Solubility

Concentration in bulk

Diffusion Coefficient

Diffusion Layer thickness

Solid


Bioavailability distribution absorption and transport

Aqeous area

BiLayer Membrane

Hydrophobic area

Aqeous area

Passive Transport

pH1

pH2


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