Bioavailability
This presentation is the property of its rightful owner.
Sponsored Links
1 / 10

Bioavailability Distribution Absorption and Transport PowerPoint PPT Presentation


  • 71 Views
  • Uploaded on
  • Presentation posted in: General

Bioavailability Distribution Absorption and Transport. Volume of Distribution. The volume of distribution is given by the following equation: Therefore the dose required to give a certain plasma concentration can be determined if the V D for that drug is known.

Download Presentation

Bioavailability Distribution Absorption and Transport

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Bioavailability

Distribution

Absorption and Transport


Volume of Distribution

The volume of distribution is given by the following equation:

Therefore the dose required to give a certain plasma concentration

can be determined if the VD for that drug is known.

The VD is not a physiologic value; it is more a reflection of how a drug

will distribute throughout the body depending

on several physicochemical properties, e.g. solubility, charge, size, etc.

VD is often calculated per weight of body – it is not volume any more!


VDProportion of Drug in body water

0.140%

0.1527%

1 4%

10 0.4%


Two compartment model

Blood

Tissue


Mode of entry of drugs/toxins

Skin transport

Respiratory route

Oral route


Organ pH Surface Area Time

Stomach1-3up to 5 m20.5-20 h

Small Intestine5-7200 m22 h

Colon7-8up to 52 h – 1 week

logC

Time


DrugBioavailability VD (L/kg weight)

Diazepam1000.5-2

Morphine15-603-5

Pentobarbital950.7-10

Tetrahydrocannabinol 69-11

VDProportion of Drug in body water

0.140%

0.1527%

1 4%

10 0.4%


Surface Area

Solubility

Concentration in bulk

Diffusion Coefficient

Diffusion Layer thickness

Solid


Aqeous area

BiLayer Membrane

Hydrophobic area

Aqeous area

Passive Transport

pH1

pH2


  • Login