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General Pathology

General Pathology. Histogenetic Classification of Neoplasms Epithelial Neoplasms. Jaroslava Dušková Inst. Pathol. ,1st Med. Faculty, Charles Univ. Prague http://www1.lf1.cuni.cz/~jdusk/. NEOPLASIA – classification. HISTOGENETIC mesenchymal epithelial neuroectodermal

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General Pathology

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  1. General Pathology Histogenetic Classification of Neoplasms Epithelial Neoplasms Jaroslava Dušková Inst. Pathol. ,1st Med. Faculty, Charles Univ. Prague http://www1.lf1.cuni.cz/~jdusk/

  2. NEOPLASIA – classification HISTOGENETIC • mesenchymal • epithelial • neuroectodermal • mixed, teratoma • choriocarcinoma • mesotelioma

  3. Epithelial Tumours • surface epithelium papillomas carcinomas / papillocarcinomas • glandular epithelium adenomas adenocarcinomas • double diff. mucoepidermoid

  4. squamous transitional urothelium papillomas carcinomas / papillocarcinomas Surface Epithelium

  5. NEOPLASIA – classification BEHAVIORAL • benign • borderline • malignant histological vs. clinical behaviour

  6. NEOPLASIA – growth benign expansive borderline - locally destructive malignant infiltrative METASTASES

  7. NEOPLASIA – macroscopy • mass • ulceration • both

  8. NEOPLASIA – cytology Benign similar to nonneoplastic Malignant cellular pleomorphism NUCLEAR FEATURES: hyperchromasia(polyploidy, aneuploidy) rough chromatine structure irregular nuclear outline large and/or multiple nucleoli or undifferentiated monotonous cellularity

  9. Malignant Tumour TYPING ICD-O GRADING G1 G2 G3 STAGING pTpNpM Tumour -Noduli-Metastases

  10. Urothelium - Precanceroses • often in the vicinity of the neoplasm • bearing the same mutations • precursors of recidives

  11. Epithelial Tumours • surface epithelium papillomas carcinomas / papillocarcinomas • glandular epithelium adenomas adenocarcinomas • double diff. mucoepidermoid

  12. Cancerogens • chemical • physical - radiation • biological • infectious – oncogenic bacteria & viruses • hormonal

  13. Carcinoma – symptoms & complications • no • mass • pressure, blockade – content/secretion retention - infection • ulceration • bleeding occult/massive – aneamia • cachexia (TNF, cachectin…)

  14. Carcinoma - diagnosis • clinical investigation, imaging • cytopathology • histopathology

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