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Program Status VCDE Workspace Meeting August 18, 2011 John Speakman Chief Program Officer

Program Status VCDE Workspace Meeting August 18, 2011 John Speakman Chief Program Officer. Things Have Changed in Biomedicine. Pre-2004: Bioinformatics was siloed : no community, few common standards, culturally little sense of the benefits of data exchange Today:

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Program Status VCDE Workspace Meeting August 18, 2011 John Speakman Chief Program Officer

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  1. Program Status VCDEWorkspace Meeting August 18, 2011 John Speakman Chief Program Officer

  2. Things Have Changed in Biomedicine • Pre-2004: • Bioinformatics was siloed: no community, few common standards, culturally little sense of the benefits of data exchange • Today: • Collaborations more common among Cancer Centers, industry, and advocacy organizations • Discovery-based consortia that share data • Recognition of the need for standards (although lag in adoption) • Personalized medicine approaches (i.e., genotyping of patients and tumors) becoming more common • Large, institution-wide initiatives emerging that rely on large-scale data integration

  3. Things Have Changed for caBIG® • caBIG® is no longer the only game in town • Our scope has broadened • Tangible evidence of groups outside the NCI-supported community wanting to contribute • Constrained from pursuing new ideas due to the weight of existing tools to maintain • Limited government appetite for programs • Impact of March 2011 report of NCI Board of Scientific Advisors

  4. Where We Are – Post-BSA Report • NCI response to BSA report was presented at 6/20 BSA meeting • Scientific Advisory Group has been established • Ad hoc committee of the BSA • Will evaluate scientific merit of ongoing and planned initiatives • Will advise BSA and the NCI Director about steps that should be taken to improve the caBIG® program and to enhance its utility for current and future users of the program • First meeting in July • caBIG® to work with that group to create priorities and select projects

  5. caBIG® Scientific Advisory Group • Dan Masys, Chair - Vanderbilt University • Andrea Califano – Columbia University (BSA) • Jean Wang – UC San Diego • Joe Gray – University of Oregon (BSA) • Rebecca Kush – Clinical Data Interchange Standards Consortium • Gaddy Getz - MIT • Lynn Vogel – MD Anderson Cancer Center • Robert Comis - Coalition of Cancer Cooperative Groups • Paul Fearn – Fred Hutchinson Cancer Center • Lincoln Stein – University of Ontario • Brian Athey – University of Michigan • One additional invitation is pending

  6. Where We Are – Post-BSA Report NCI Leadership agrees that: • caBIG® must be refocused on the core components of ‘creation and management of standards for data exchange and support of community-based software tools’ • Central tenet of program is ‘development, maintenance, enhancement, and dissemination of software tools by the academic research community’ • Newly formed Scientific Advisory Group (SAG) will meet as soon as possible to engage participation of researchers • Must continue exploring strategies to maintain open-source community • All non-core development is to be phased out • Budget must be scrutinized and adjusted for new scope

  7. Next Steps and Priorities • NCI remains committed to caBIG®, but will refocus the effort and retain key pieces identified as important to the cancer research community • Key effort will be facilitating community-developed informatics that provide insight in cancer biology and clinical research • The SAG will foster collaboration with the community, help set priorities, and ensure timely communications • There will be continued support for academic IT efforts, with priorities developed in partnership with NCI Scientific Divisions • Support is through grants, where appropriate, and dedicated funding as necessary

  8. Guiding Principles • Collaborate more closely with the cancer research community, with oversight by the SAG • Retain stewardship of the development of community-driven technical standards and interoperability frameworks • Foster the academic research community’s biomedical informatics development efforts through peer-reviewed, investigator-initiated, and high-priority, targeted efforts executed through the NCI Scientific Divisions • Meet community-identified software development and support needs through partnerships with external open-source development communities

  9. Community-generated Tools • caBIG® will continue to provide support to academic groups through its Knowledge Center program, to provide community support for the tools and infrastructure they provide • All community tools are open-source, and the software will continue to be made available through NCI web sites (the Support Service Providers program – with 20 SSPs to date – will continue to be available to the community for support of local installation and customization) • Areas assessed by the SAG as important may have additional NCI-funded development through external open-source community effort • The caBIG® community will continue to develop and maintain the standards and interoperability specifications necessary to keep the parts working together

  10. Academic Development of Novel Informatics Capabilities • caBIG® will collaborate with NCI Scientific Divisions to foster efforts addressing current and evolving needs • Possible projects include: • Integration and analysis of multi-dimensional data • Storage and distribution of “Big Data” • Data visualization and interpretation • Natural language processing • Analysis of in vivo images • Development of new approaches for generating evidence • These examples are subject to review by the SAG

  11. Enterprise Informatics Capabilities • NCI will transfer stewardship of community-developed tools to external, open-source community including: • Molecular analysis • Management of high-dimensional molecular characterization data • Biospecimen management • Clinical research tools • In vivo imaging • Multi-center, genetically informed, adaptive clinical trials

  12. Support Through the caBIG® Program, NCI will: • Help with long-term dissemination and support of community-developed software by maintaining infrastructure to store software, along with its documentation, and associated metadata • Support academic institutions by ensuring resources are available for local installation, customization and ongoing extension, through its Knowledge Center Program • Partner with external open-source development community organizations to provide long-term support for software extension and enhancement outside the NCI mission

  13. Where We Are - Internally • Reviewing mission, strategy, goals • Realigning our activities so they are consistent with the current and planned future state of the program and new budgets • Moving forward with new plans and activities • Optimistic that our renewed focus and partnership with the SAG will lead to positive outcomes for the community

  14. caBIG® Program Shifts Proactive oversight by BSA Newly-formed Scientific Advisory Group (SAG) will help foster collaboration with the community, help set priorities, and ensure timely communications Provide a bridge to scientific community, who will have ownership of the projects / goals of the program Rigorous prioritization and alignment with strategic goals will become the norm Shift to development of software in open source community Extensive work already accomplished by caBIG® Task Force caBIG ® role as stakeholder, but not as controlling entity

  15. caBIG® Program Shifts Key focus on facilitating community-developed informatics that provide insight in cancer biology and clinical research Support to be implemented through grants, where appropriate, and dedicated funding as necessary New incentive models Renewed focus on relationships with other NCI divisions Maintaining, building, shifting to accommodate new goals

  16. caBIG® - What Won’t Change Relationship with the community A key strength, and the reason we’re here Investment in caBIG® tools will not be wasted We will protect and support our user base through transitions Governance model for Open Source will be shaped to meet community needs Push for interoperability and data sharing Focus on the NCI core mission: “Progress in the treatment, diagnosis, and prevention of cancer”

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