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Lecture 5. August 10, 2005. Lehninger Chapter 14 (4 th ed.) complete sections 14.2 and 14.3 skip section 14.4 for now. Lehninger Chapter 15 (4 th ed.). METABOLISM OF GLYCOGEN. Enzymes required for galactose metabolism. kinase. Galactose Galactose 1-P. UDP-Glu.

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lecture 5

Lecture 5

August 10, 2005

Lehninger Chapter 14 (4th ed.) complete sections 14.2 and 14.3

skip section 14.4 for now

Lehninger Chapter 15 (4th ed.)

METABOLISM OF GLYCOGEN

slide2

Enzymes required for galactose metabolism

kinase

Galactose Galactose 1-P

UDP-Glu

ATP ADP

Uridyl transferase

epimerase

UDP-Gal

Glucose 1-P

phosphoglucomutase

Glucose 6-P

3 enzymes of glycogen breakdown glycogenolysis
3 enzymes of glycogen breakdown(Glycogenolysis)
  • glycogen phosphorylase
  • glycogen debranching enzyme
  • phosphoglucomutase
slide6

Non-reducing

end

Reducing end

Figure 7-11

slide7

Can reduce Cu2+

Oxidized sugar

Cannot reduce Cu2+

Figure 7-10

Note this shows the β, not α configuration

slide8

OH

Figure 15-3

slide9

Pyridoxal phosphate

cofactor

4

3

2

1

4

3

2

1

Figure 15-4

slide10

Pyridoxal phosphate

cofactor

Figure 15-3

3 enzymes of glycogen breakdown glycogenolysis1
3 enzymes of glycogen breakdown(Glycogenolysis)
  • glycogen phosphorylase
  • glycogen debranching enzyme [oligo (α1→6) to (α1→4) glucantransferase]
  • phosphoglucomutase
slide13

4

3

2

1

4

3

2

1

1

4

3

2

4

3

2

1

Figure 15-4

slide14

Hydrolysis, NOT

Phosphorolysis

Figure 15-4

3 enzymes of glycogen breakdown glycogenolysis2
3 enzymes of glycogen breakdown(Glycogenolysis)
  • glycogen phosphorylase
  • glycogen debranching enzyme
  • Phosphoglucomutase

Glu-1-P ↔ Glu-6-P

slide16

Glu 1-P  Glu 6-P

phosphoglucomutase

Figure 15-5

slide18

GLYCOGEN METABOLISM

GLYCOGEN SYNTHESIS

LNC Chapter 15 (Section 1)

glu atp glu 6 p adp

Glu + ATP → Glu-6-P + ADP

Enzymes:

hexokinase I and

hexokinase II in muscle,

hexokinase IV (glucokinase) in liver

glu 6 p glu 1 p

Glu-6-P ↔ Glu-1-P

Phosphoglucomutase

glu 1 p utp udp glu pp i
Glu-1-P + UTP → UDP-Glu + PPi

Glu-1-P

UDP-Glu

Figure 15-7

slide23

Start with glycogenin,

a primer and enzyme.

Muscle form and

Liver form (glycogenin-2)

+

Figure 15-10

UDP-glucose

slide25

LNC (3rd ed) 20-14

(not found in 4th edition)

slide32

GLYCOGEN

UDP-Glu Glu-1P

Glu-6P

Fru-6P

Fru-1,6 bis P

DHAP + GAP

synthase

phosphorylase

Fructose-1,6-bis

phosphatase

Phosphofructokinase

(PFK-1)

slide34

Covalent modifications

Ligand-induced

conformational

changes

slide38

adenyl

cyclase

ATP

cAMP

phosphodiesterase

ADP

AMP

slide39

guanyl

cyclase

GTP

cGMP

phosphodiesterase

slide41

hormone

Glycogen ==> Glu-1-P

slide45

Adenylate kinase

2 ADP

ATP

AMP

+

K = 0.44

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