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A Naturopathic Perspective. Prostate Cancer Prevention and Treatment. Susan Fisher M.Sc.(Pharmacology), N.D. A Message to my Audience:. I enjoyed our discussion Wed night and wanted you to know my website (mahayacambridge.com) will be updated by mid-November.

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A naturopathic perspective

A Naturopathic Perspective

Prostate Cancer Prevention and Treatment

Susan Fisher M.Sc.(Pharmacology), N.D.


A message to my audience

A Message to my Audience:

  • I enjoyed our discussion Wed night and wanted you to know my website (mahayacambridge.com) will be updated by mid-November.

  • Also – of the veggies we discussed, choose to eat more of broccoli and cauliflower (I will explain more next time…)


In the next 45 minutes

In the next 45 minutes…

  • Even the playing field

  • Inspire Health (Vancouver)

  • Inflammation

  • Nutrients in a Tomato

  • Whole Foods

  • Some Tools in my Toolkit


A naturopathic perspective

Naturopathic Medicine

Naturopathic medicine is a distinct system of primary healthcare

Addresses the root cause of illness or disease

Promotes health and healing using natural therapies


A naturopathic perspective

NDvs MD / GP – Academic Background


A naturopathic perspective

NDvs MD/GP – Academic Background

Before Entry toMedical School

Bachelor of Science


A naturopathic perspective

NDvs MD/GP – Academic Background

Anatomy, Histology, PathologyPhysiology, Pharmacology, Radiology, Biochemistry, Clinical Nutrition, Differential DiagnosisClinical Diagnosis, Immunology,Embryology, Public Health

Naturopathic andConventional Medicine

Years 1-3

Before Entry toMed School

Bachelor of Science


A naturopathic perspective

NDvs MD/ GP – Academic Background

Natural Therapies etc.

Drugs / Surgery

Naturopathic /

Conventional Medicine

Years 3-4: Clinic Intern

Anatomy, Histology, PathologyPhysiology, Pharmacology, Radiology, Biochemistry, Clinical Nutrition, Differential DiagnosisClinical Diagnosis, Immunology,Embryology, Public Health

Naturopathic andConventional Medicine

Years 1-3

Before Entry toMed School

Bachelor of Science


A naturopathic perspective

Clinical Nutrition

  • Examining the relationship between diet and health

  • Developing individualized diets

  • Treatments may include nutritional supplements like vitamins, minerals, enzymes and other nutraceuticals


A naturopathic perspective

Lifestyle Counseling

  • Helping patients to make informed choices to be healthy

  • Understanding the physical, emotional, nutritional and environmental factors affecting well-being


A naturopathic perspective

Body Mind Spirit

SPIRIT

BODY

BODY

MIND

SPIRIT

MIND

Root Cause of Disease


A naturopathic perspective

Botanical Medicine

  • Understanding the healing value of plant substances

  • Utilizing the plant substances and the knowledge of healing from around the world


A naturopathic perspective

Curcumin /Turmeric (Curcuma longa)


A naturopathic perspective

Green Tea (Camellia sinensis)


A naturopathic perspective

Asian Medicine

  • Balancing the flow of Chi (energy) through meridian pathways

  • Includes the use of acupuncture and Oriental herbs


A naturopathic perspective

Homeopathic Medicine

  • Stimulating self-healing mechanisms through the use of natural substances

  • Based on the principle that “likes cures like”


A naturopathic perspective

Reducing Cancer Risk and Optimizing Survival

Dr. Hal Gunn, M.D.

CEO InspireHealth


A naturopathic perspective

Role of the Tumour Microenvironment

  • The pattern of gene expression of cells in the tumour stroma is highly correlated with prognosis.

  • More highly correlated than tumour grade, whether the patient was treated with chemotherapy, or whether the cancer had spread to the lymph nodes.

    • Finak, G et al. Nature Medicine 14 (5) May 2008 518-27

  • In other words, the environment of our body and what our immune cells are doing is the most important factor in determining prognosis


The human macrophage

The Human Macrophage


The human macrophage1

The Human Macrophage

M1:FIGHTINGINVADERS


The human macrophage2

The Human Macrophage

M1:FIGHTINGINVADERS

M2:TISSUE REPAIR


The human macrophage3

The Human Macrophage

Invader Attacking RoleAcute Inflammationeg. Cut yourself

OR

Tissue Repair RoleChronic Inflammationeg. Arthritis, High Cholesterol, Obesity, Heart Disease, Diabetes, Autoimmune


A naturopathic perspective

Positive Association of M1 Macrophages and Survival

Ma J et al, The M1 form of tumor-associated macrophages in NSCLC is positively associated with survival time. BMC Cancer 2010 (10) 112


A naturopathic perspective

MACROPHAGES: TWO IMPORTANT ROLES

M1 : Invader Attacking Role

Tumor suppression and invader / cancer cell destruction

M1 Cells Attacking Tumor

Inhibit cancer growth

(acute inflammation)


A naturopathic perspective

M2 Macrophages Help the Cancer Tumour to Grow

  • M2: Tissue Repair /Growth

    • -Growth factor production

    • Angiogenesis

    • Suppress immune function

    • Coordinate tissue growth

M2 Cells:

Helping tumorto grow larger.

Promote cancer growth

(chronic inflammation)


Prostate cancer is an inflammatory condition

Prostate Cancer is an Inflammatory Condition!

  • Interleukin-6 (IL-6), tumour necrosis factor (TNF), vascular endothelial growth factor (VEGF), fibroblast growth factors (FGF) are among the inflammatory substances believed contributing to growth of cancer

  • These cytokines are all elevated in Prostate cancer.

  • Extent of inflammation is monitored by CRP (C-reactive Protein level) and PSA levels


How to reduce inflammation

How to Reduce Inflammation

  • Healthy alkaline diet (7+fruits/ veggies, water, omega-3 fats; limit alcohol /caffeine/ red meat)

  • Regular exercise

  • Absence of chronic diseases

  • Healthy stress reduction

  • Self-awareness and healthy emotional well being


A naturopathic perspective

Reversing Rising PSA in Early Prostate Cancer

  • Control group: average 6% rise PSA 1 year.

  • 6 of 46 men progressed to surgery/radiation.

  • Treatment group:average 4% decline PSA 1 year.

  • None of the men progressed to surgery/radiation.

  • Journal of urology, 2005, 174:1065-1070


A naturopathic perspective

Vegetarian diet

Exercise

Meditation

Reversing Rising PSA in Early Prostate Cancer

  • Control group: average 6% rise PSA 1 year.

  • 6 of 46 men progressed to surgery/radiation.

  • Treatment group:average 4% decline PSA 1 year.

  • None of the men progressed to surgery/radiation.

HEALTHY LIFESTYLE CHANGES


A naturopathic perspective

Reversing Rising PSA in Early Prostate Cancer

  • Control group: average 6% rise PSA 1 year.

  • 6 of 46 men progressed to surgery/radiation.

  • Treatment group:average 4% decline PSA 1 year.

  • None of the men progressed to surgery/radiation.

  • Growth of LNCaP prostate cancer cells inhibited 70% by treatment group serum vs. Only 9% by control group serum.


A naturopathic perspective

Mol NutrFood Res.2009 Feb53(2): 227-39


A naturopathic perspective

Phytochemical and Ethnobotanical Databases

Nutrients in: A Tomato

www.Ars-grin.gov\duke


Phytonutrients in a tomato 1

Phytonutrients in a Tomato (1)

1',2'-EPOXY-1',2'-DIHYDRO-BETA-EPSILON-PSEUDOCAROTENE Fruit DUKE1992A

1',2'-EPOXY-1',2'-DIHYDRO-BETA-PSI-CAROTENE Fruit DUKE1992A

1,2-EPOXY-1,2-DIHYDRO-PSI,PSI-CAROTENE Fruit DUKE1992A

1-BUTYL-2-THIAZOL Fruit DUKE1992A

1-O-FERULOYL-BETA-D-GLUCOSE Fruit DUKE1992A

1-O-P-COUMAROYL-BETA-D-GLUCOSE Fruit DUKE1992A

10,16-DIHYDROXY-DECANOIC-ACID Fruit DUKE1992A

10,16-DIHYDROXY-HEXADECANOIC-ACID Fruit DUKE1992A

16-HYDROXY-HEXADECANOIC-ACID Fruit DUKE1992A

2,7-DIMETHYL-OCT-4-ENEDIOIC-ACID Shoot 1.2 DUKE1992A

2,7-DIMETHYL-OCTA-2,4-DIENOIC-ACID Shoot 1.8 DUKE1992A

2-BUTANONE Fruit DUKE1992A

2-PENTANONE Fruit DUKE1992A

2-PROPANONE Fruit DUKE1992A

24-(R)-ETHYL-LOPHENOL Seed DUKE1992A

24-METHYL-31-NOR-LANOST-9(11)-EN-3-BETA-OL Seed DUKE1992A

24-METHYL-LOPHENOL Seed DUKE1992A

24-METHYLENE-CYCLOARTANAL Seed DUKE1992A

24-METHYLENE-CYCLOARTENAL Plant DUKE1992A


Phytonutrients in a tomato 2

Phytonutrients in a Tomato (2)

  • 3-BETA-HYDROXY-5-ALPHA-PREG-16-EN-20-ONE Shoot DUKE1992A

  • 3-O-FERULOYL-QUINIC-ACID Leaf DUKE1992A

  • 31-NOR-LANOST-8-EN-3-BETA-OL Seed DUKE1992A

  • 31-NOR-LANOST-8-EN-3-BETA-OL Seed DUKE1992A

  • 31-NOR-LANOST-9(11)-EN-3-BETA-OL Seed DUKE1992A

  • 31-NORCYCLOARTENAL Seed DUKE1992A

  • 4-ALPHA-24-DIMETHYL-CHOLESTA-7,24-DIEN-3-BETA-OL Seed DUKE1992A

  • 4-ALPHA-METHYL-24-ETHYL-CHOLESTA-7,24-DIEN-3-BETA-OL Seed DUKE1992A

  • 4-VINYL-GUAIACOL Leaf DUKE1992A

  • 4-VINYL-GUAIACOL Seed DUKE1992A

  • 5,6-EPOXY-5,6-DIHYDRO-PSEUDO-PSEUDOCAROTENE Fruit DUKE1992A

  • 5-HYDROXYTRYPTAMINE Fruit DUKE1992A


Phytonutrients in a tomato 3

Phytonutrients in a Tomato (3)

  • ABSCISIC-ACID-1',4'-TRANS-DIOL Fruit DUKE1992A

  • ABSCISIC-ACID-1',4'-TRANS-DIOL Leaf DUKE1992A

  • ABSCISIC-ACID-1'O-BETA-D-GLUCOPYRANOSIDE Stem DUKE1992A

  • ACETALDEHYDE Fruit DUKE1992A

  • 5ALPHA-FUROSTANE-3BETA,22,26TRIOL-3-O-BETA-D-GLUCOPYRANOSYL... Plant DUKE1992A

  • 9,10,16-TRIHYDROXYHEXADECANOIC-ACID Fruit DUKE1992A

  • 9,10,18-TRIHYDROXY-OCTADECANOIC-ACID Fruit DUKE1992A

  • ABSCISIC-ACID Leaf DUKE1992A

ALUMINUM Fruit 0.3 1700 DUKE1992A

ARABIC-ACID Fruit DUKE1992A

ARGININE Fruit 1 3637 DUKE1992A

ARSENIC Fruit 0.003 0.043 DUKE1992A

ASCORBIC-ACID Fruit 50 2952 DUKE1992A


Phytonutrients in a tomato 4

Phytonutrients in a Tomato (4)

ACETIC-ACID Fruit DUKE1992A

ACETONE Fruit DUKE1992A

ADENOSINE Flower DUKE1992A

ALANINE Fruit 30 4132 DUKE1992A

ALPHA-AMYRIN Fruit DUKE1992A

ALPHA-CAPROLACTONE Fruit DUKE1992A

ALPHA-IONENE Fruit DUKE1992A

ALPHA-KETO-GLUTARIC-ACID Fruit DUKE1992A

ALPHA-LINOLENIC-ACID Fruit 30 496 DUKE1992A

ALPHA-NONALACTONE Fruit DUKE1992A

ALPHA-OCTALACTONE Fruit DUKE1992A

ALPHA-OXOGLUTARIC-ACID Fruit DUKE1992A

ALPHA-PINENE Fruit DUKE1992A

ALPHA-TOCOPHEROL Fruit 7 143 DUKE1992A


Phytonutrients in a tomato 5

Phytonutrients in a Tomato (5)

ASH Fruit 5700 105461 DUKE1992A

ASPARAGINE Fruit 300 DUKE1992A

ASPARTIC-ACID Fruit 1230 20332 DUKE1992A

AUROXANTHIN Fruit DUKE1992A

BETA-ALANINE Fruit 6 DUKE1992A

BETA-AMYRIN Fruit DUKE1992A

BETA-CAROTENE Fruit 7 113 DUKE1992A

BETA-D-GLUCOPYRANOSYL-PHASEIC-ACID Plant DUKE1992A

BETA-IONENE Fruit DUKE1992A

BETA-SITOSTEROL Fruit DUKE1992A

BETAINE Root 23 DUKE1992A

BETAINE Shoot 69 DUKE1992A

BIOTIN Fruit DUKE1992A

BORON Fruit 0 96 DUKE1992A

BUTANOL-2-ON-3 Fruit DUKE1992A


Phytonutrients in a tomato 6

Phytonutrients in a Tomato (6)

BUTANOLS Fruit DUKE1992A

BUTYROLACTONE Fruit DUKE1992A

CADMIUM Fruit 0.005 1.7 DUKE1992A

CAFFEIC-ACID Fruit 6 DUKE1992A

CAFFEIC-ACID-4-O-BETA-D-GLUCOSIDE Fruit DUKE1992A

CALCIUM Fruit 60 2400 DUKE1992A

CALCIUM Leaf 60800 DUKE1992A

CAMPESTEROL Fruit DUKE1992A

CAPRYLIC-ACID Fruit DUKE1992A

CARBOHYDRATES Fruit 43400 717400 DUKE1992A

CARBOXYLIC-ACID Leaf DUKE1992A

CELLULASE Fruit DUKE1992A

CELLULOSE Fruit DUKE1992A

CERIUM Fruit 7 60 DUKE1992A

CHLORINE Fruit 510 DUKE1992A

CHLOROGENIC-ACID Fruit 18 DUKE1992A


Phytonutrients in a tomato 7

Phytonutrients in a Tomato (7)

CHOLINE Root 36 DUKE1992A

CHOLINE Shoot 48 DUKE1992A

CHROMIUM Fruit 0 3 DUKE1992A

CINNAMALDEHYDE Fruit DUKE1992A

CIS-3-HEXENOL-1 Fruit 4 40 DUKE1992A

CIS-5'-BETA-PSEUDOCAROTENE Fruit DUKE1992A

CIS-5'-EPSILON-PSEUDOCAROTENE Fruit DUKE1992A

CIS-5'-NEUROSPORENE Fruit DUKE1992A

CIS-5,CIS-5'-LYCOPENE Fruit 1 20 DUKE1992A

CIS-5-LYCOPENE Fruit 1 20 DUKE1992A

CIS-HEXEN-3-AL Fruit DUKE1992A

CITRAL Fruit DUKE1992A

CITRIC-ACID Fruit DUKE1992A

CITROSTADIENOL Seed DUKE1992A

COBALT Fruit 0 1.4 DUKE1992A

COPPER Fruit 0.4 100 DUKE1992A

CUTIN Fruit DUKE1992A

CYCLOARTANOL Seed DUKE1992A

CYCLOARTENOL Seed DUKE1992A

CYCLOEUCALENOL Seed DUKE1992A

ZEATIN-RIBOSIDE Flower DUKE1992A

ZEAXANTHIN Fruit DUKE1992A

ZETA-CAROTENE Fruit DUKE1992A

ZINC Fruit 1 120 DUKE1992A

ZIRCONIUM Fruit 0 4 DUKE1992A


Phytonutrients in a tomato 8

Phytonutrients in a Tomato (8)

CYCLOHEXANOL Fruit DUKE1992A

CYSTINE Fruit 120 1984 DUKE1992A

DAMASCENONE Fruit DUKE1992A

DECADIEN-TRANS-2,TRANS-4-AL Fruit DUKE1992A

DIACETYL Fruit DUKE1992A

DIHYDROXYTARTARIC-ACID Fruit DUKE1992A

DIHYDROZEATIN Flower DUKE1992A

EPOXY-5,6-IONENE Fruit DUKE1992A

EPOXY-LUTEIN Fruit DUKE1992A

ETHANOL Fruit DUKE1992A

ETHYL-PHENOL Fruit DUKE1992A

ETHYLENE Fruit DUKE1992A

EUGENOL Fruit DUKE1992A

TRIGONELLINE Root 69 DUKE1992A

TRIMETHYL-2,6,6-HYDROXY-2-CYCLOHEXANONE Fruit DUKE1992A

TRYPTAMINE Fruit DUKE1992A

TRYPTOPHAN Fruit 1 1157 DUKE1992A

TYRAMINE Fruit DUKE1992A

TYROSINE Fruit 38 2479 DUKE1992A

UBIQUINONE-10 Tissue Culture 60 DUKE1992A

VALINE Fruit 1 3801 DUKE1992A

VANADIUM Fruit 0 6 DUKE1992A

VANILLIN Plant DUKE1992A

VIOLAXANTHIN Fruit DUKE1992A

VIT-B-6 Fruit 0 9 DUKE1992A

WATER Fruit 910000 982000 DUKE1992A

XANTHOPHYLL Fruit DUKE1992A

YTTRIUM Fruit 0 6 DUKE1992A

ZEATIN Fruit DUKE1992A

ZEATIN-GLUCOSIDE Flower DUKE1992A

FALCARINDIOL Seed DUKE1992A

FALCARINOL Seed DUKE1992A

FARNESAL Fruit DUKE1992A

FARNESYL-ACETONE Fruit DUKE1992A

FAT Fruit 1330 47441 DUKE1992A

FAT Seed 150000 250000 DUKE1992A

FERULIC-ACID Fruit DUKE1992A


Phytonutrients in a tomato 9

Phytonutrients in a Tomato (9)

FALCARINDIOL Seed DUKE1992A

FALCARINOL Seed DUKE1992A

FARNESAL Fruit DUKE1992A

FARNESYL-ACETONE Fruit DUKE1992A

FAT Fruit 1330 47441 DUKE1992A

FAT Seed 150000 250000 DUKE1992A

FERULIC-ACID Fruit DUKE1992A

FERULIC-ACID-O-BETA-D-GLUCOSIDE Fruit DUKE1992A

FIBER Fruit 4700 77691 DUKE1992A

FLUORINE Fruit 0.02 1.7 DUKE1992A

FOLACIN Fruit 0 2 DUKE1992A

FORMIC-ACID Fruit DUKE1992A

FRUCTOSE Fruit 11700 DUKE1992A TARTARIC-ACID Fruit DUKE1992A

TETRA-DECA-CIS-6-ENE-1,3-DIYNE-5,8-DIOL Stem DUKE1992A

THIAMIN Fruit 1 10 DUKE1992A

THREONINE Fruit 65 3637 DUKE1992A

TITANIUM Fruit 0 140 DUKE1992A

FUMARIC-ACID Fruit DUKE1992A

FURFURAL Fruit DUKE1992A

GABA Fruit 220 480 DUKE1992A

GAMMA-CAROTENE Fruit DUKE1992A

GENTISIC-ACID Leaf DUKE1992A

GERANYL-ACETONE Fruit DUKE1992A

TOMATIDA-3,5-DIENE Shoot DUKE1992A

TOMATIDINE Plant DUKE1992A

TOMATINE Flower DUKE1992A

TOMATINE Leaf 6 8 DUKE1992A

TOMATOSIDE-A Seed DUKE1992A

TRANS-ACONITIC-ACID Fruit DUKE1992A


Phytonutrients in a tomato 10

Phytonutrients in a Tomato (10)

GIBBERELLINS Fruit DUKE1992A

GLUCOSE Fruit 16300 DUKE1992A

GLUTAMIC-ACID Fruit 90 54053 DUKE1992A

GLYCERIC-ACID Fruit DUKE1992A

GLYCINE Fruit 23 3637 DUKE1992A

GLYCOLIC-ACID Fruit DUKE1992A

GLYOXAL Fruit DUKE1992A

GRAMISTEROL Seed DUKE1992A

GUAIACOL Fruit DUKE1992A

HEMICELLULOSE Fruit DUKE1992A

HEPTADIEN-TRANS-2,CIS-4-AL Fruit DUKE1992A

HEPTADIEN-TRANS-2,TRANS-4-AL Fruit DUKE1992A

HEPTULOSE Fruit DUKE1992A

HEXADIEN-TRANS-2-,TRANS-4-AL Fruit DUKE1992A

SILICON Fruit DUKE1992A

SILVER Fruit 0 1.4 DUKE1992A

SODIUM Fruit 10 6600 DUKE1992A

SOLADULCIDINE Shoot DUKE1992A

SOLANINE Fruit DUKE1992A

SQUALENE Fruit DUKE1992A

STARCH Fruit 120 10000 DUKE1992A

STEARIC-ACID Fruit 80 1322 DUKE1992A

STIGMASTEROL Fruit DUKE1992A

STRONTIUM Fruit 0 140 DUKE1992A

SUCCINIC-ACID Fruit DUKE1992A

SUCROSE Fruit DUKE1992A

SUGARS Fruit 15000 45000 DUKE1992A

SULFOQUINOVOSYL-DIACYL-GLYCEROL Leaf DUKE1992A

SULFUR Fruit 107 2330 DUKE1992A

SYRINGALDEHYDE Plant DUKE1992A

HEXANOLS Fruit DUKE1992A

HISTIDINE Fruit 30 2149 DUKE1992A

HYDROCINNAMALDEHYDE Fruit DUKE1992A

I-VALERALDEHYDE Fruit DUKE1992A

I-VALERIC-ACID Fruit DUKE1992A

INDOLE-3-ACETIC-ACID Root DUKE1992A


Phytonutrients in a tomato 11

Phytonutrients in a Tomato (11)

IODINE Fruit DUKE1992A

IRON Fruit 1 800 DUKE1992A

ISOAMYLOL Fruit 7 40 DUKE1992A

ISOLEUCINE Fruit 210 3471 DUKE1992A

ISOPENTENYL-ADENINE Root DUKE1992A

ISOPENTENYL-ADENOSINE Root DUKE1992A

ISOVALERALDEHYDE Fruit 0.006 DUKE1992A

JSGGALACTURONIC-ACID Fruit DUKE1992A

KAEMPFEROL Seed DUKE1992A

KETOHEPTOSE Fruit DUKE1992A

LACTIC-ACID Fruit DUKE1992A

LANOSTEROL Seed DUKE1992A

LEAD Fruit 0.003 60 DUKE1992A

LEUCINE Fruit 330 5455 DUKE1992A

LEUCINES Fruit 1 90 DUKE1992A

LEUCIONPINE Tissue Culture DUKE1992A

LEUCIONPINE-LACTAM Tissue Culture DUKE1992A

LINALOL Fruit DUKE1992A

LINOLEIC-ACID Fruit 830 13720 DUKE1992A

PROTOPECTIN Fruit 11700 24200 DUKE1992A

PYRUVIC-ACID Fruit DUKE1992A

QUERCETIN Fruit DUKE1992A

QUERCETIN-3-O-RHAMNOSIDE Fruit DUKE1992A

QUERCITRIN Fruit DUKE1992A

RIBOFLAVIN Fruit 1 8 DUKE1992A

RISHITIN Plant DUKE1992A

RUBIDIUM Fruit 0.3 22 DUKE1992A

RUTIN Fruit DUKE1992A

RUTIN Leaf 24000 DUKE1992A

RUTINOSIDE Fruit DUKE1992A

S-METHYL-METHIONINE Fruit 16 35 DUKE1992A

SALICYLALDEHYDE Fruit DUKE1992A

SELENIUM Fruit 0.001 0.034 DUKE1992A

SERINE Fruit 57 3967 DUKE1992A


Phytonutrients in a tomato 12

Phytonutrients in a Tomato (12)

LINOLENIC-ACID Fruit DUKE1992A

LITHIUM Fruit 0.28 0.68 DUKE1992A

LOPHENOL Seed DUKE1992A

LUPEOL Plant DUKE1992A

LUTEIN Fruit DUKE1992A

LUTEIN-5,6-EPOXIDE Fruit DUKE1992A

LUTEIN-EPOXIDE Fruit DUKE1992A

LYCOPENE Fruit 1 20 DUKE1992A

LYCOPERSICONOL Root DUKE1992A

LYCOPERSICONOLIDE Root 6.7 DUKE1992A

LYCOPHYLL Fruit DUKE1992A

LYCOXANTHIN Fruit DUKE1992A

LYSINE Fruit 20 5455 DUKE1992A

MAGNESIUM Fruit 70 6000 DUKE1992A

MAGNESIUM Leaf 4300 DUKE1992A

MALIC-ACID Fruit DUKE1992A

MANGANESE Fruit 0.6 100 DUKE1992A

MERCURY Fruit 0.001 0.002 DUKE1992A

METHANOL Fruit DUKE1992A PHOSPHORUS Fruit 110 8400 DUKE1992A

PHOSPHORUS Leaf 5500 DUKE1992A

PHYLLOQUINONE Plant 0.06 JN128:785

PHYTOENE Fruit DUKE1992A

PHYTOENE-1,2-OXIDE Fruit DUKE1992A

PHYTOFLUENE Fruit DUKE1992A

PHYTOSTEROLS Fruit 70 1157 DUKE1992A

PIPECOLIC-ACID Fruit DUKE1992A

POLYGALACTURONASE Fruit DUKE1992A

POTASSIUM Fruit 780 58800 DUKE1992A

POTASSIUM Leaf 47000 DUKE1992A

PROLINE Fruit 170 2810 DUKE1992A

PROLINE Root 541 DUKE1992A

METHIONINE Fruit 16 1322 DUKE1992A


Phytonutrients in a tomato 13

Phytonutrients in a Tomato (13)

LYCOPERSICONOL Root DUKE1992A

LYCOPERSICONOLIDE Root 6.7 DUKE1992A

LYCOPHYLL Fruit DUKE1992A

LYCOXANTHIN Fruit DUKE1992A

LYSINE Fruit 20 5455 DUKE1992A

MAGNESIUM Fruit 70 6000 DUKE1992A

MAGNESIUM Leaf 4300 DUKE1992A

MALIC-ACID Fruit DUKE1992A

MANGANESE Fruit 0.6 100 DUKE1992A

MERCURY Fruit 0.001 0.002 DUKE1992A

METHANOL Fruit DUKE1992A

METHIONINE Fruit 16 1322 DUKE1992A

METHYL-2-BUTYRIC-ACID Fruit DUKE1992A

METHYL-6-HEPTEN-5-ON-2 Fruit DUKE1992A

METHYL-GLYOXAL Fruit DUKE1992A

METHYL-SALICYLATE Fruit DUKE1992A

MEVALONIC-ACID Fruit 3 4 DUKE1992A

MOLYBDENUM Fruit 0 6 DUKE1992A

MYRISTIC-ACID Fruit DUKE1992A

N(6)-ISOPENT-2-ENYL-ADENINE Flower DUKE1992A

N-DOTRIACONTANE Fruit DUKE1992A

N-HENTRIACONTANE Fruit DUKE1992A

N-HEXANOL Fruit DUKE1992A

NEO-BETA-CAROTENE-B Fruit DUKE1992A

NEO-BETA-CAROTENE-U Fruit DUKE1992A

NEO-CHLOROGENIC-ACID Leaf DUKE1992A

NEODYMIUM Fruit 2 30 DUKE1992A

NEOLYCOPENE-A Fruit DUKE1992A

N-PENTANOL Fruit 7 40 DUKE1992A

N-TETRATRIACONTANE Fruit DUKE1992A

N-TRITRIACONTANE Fruit DUKE1992A

NARCOTINE Fruit DUKE1992A

NARINGENIN Fruit DUKE1992A


Phytonutrients in a tomato 14

Phytonutrients in a Tomato (14)

NEOLYCOPENE-B Fruit DUKE1992A

NEOTIGOGENIN Tissue Culture 300 1500 DUKE1992A

NEOXANTHIN Fruit DUKE1992A

NESTIGOGENIN Fruit DUKE1992A

NEUROSPORINE Fruit DUKE1992A

NIACIN Fruit 6 99 DUKE1992A

NICKEL Fruit 0.01 5 DUKE1992A

NICOTIANAMINE Leaf DUKE1992A

NITROGEN Fruit 1300 23330 DUKE1992A

NITROGEN Leaf 26000 DUKE1992A

NONACOSANE Fruit DUKE1992A

O-CRESOL Fruit DUKE1992A

O-HYDROXY-ACETOPHENONE Fruit DUKE1992A

OBTUSIFOLIOL Seed DUKE1992A

OLEIC-ACID Fruit 310 5124 DUKE1992A

OXALIC-ACID Fruit 36 263 DUKE1992A

P-COUMARIC-ACID Fruit DUKE1992A

P-COUMARIC-ACID-O-BETA-D-GLUCOSIDE Fruit DUKE1992A

P-HYDROXYBENZALDEHYDE Plant DUKE1992A

PALMITIC-ACID Fruit 210 3471 DUKE1992A

PALMITOLEIC-ACID Fruit 10 165 DUKE1992A

PANTOTHENIC-ACID Fruit 1 61 DUKE1992A

PECTIN Fruit 100 31000 DUKE1992A

PECTINESTERASE Fruit DUKE1992A

PENTANOLS Fruit DUKE1992A

PENTEN-1-OL-3 Fruit DUKE1992A

PHENOL Fruit DUKE1992A

PHENOLICS Fruit 27 570 DUKE1992A

PHENYL-2-ETHANOL Fruit DUKE1992A

PHENYL-ACETALDEHYDE Fruit DUKE1992A

PHENYLACETONITRILE Fruit DUKE1992A

PHENYLALANINE Fruit 72 3801 DUKE1992A

PHOSPHATIDYL-GLYCEROL Leaf DUKE1992A


Psychoneuroimmunology and cancer

Psychoneuroimmunologyand Cancer

  • Chronic stress promotes tumour growth and angiogenesis inanimal model of ovarian cancer.

    Nature Medicine 2006; 12: 939-45

SPIRIT

BODY

MIND


Cortisol and your immune system

Cortisol and your Immune System

IncreasedCortisol –(Stress Hormone)

Decreased BodyDefenses


Stress reduction

Stress Reduction

  • 49 breast and 10 prostate patients

  • 8 week mindfulness-based stress reduction program

  • During follow-up period of 6 /12 months:

    • constant decline in cortisol levels / pro-inflammatory cytokines

    • Enhance Q of L, less stress / mood disturbances

Brain Behav Immun. 2007 Nov; 21(8): 1038-49


Complementary approaches

Complementary Approaches

  • Lifestyle and Diet

  • Anti-oxidants

  • Melatonin

  • Serenoa repens (Saw palmetto)

  • Omega 3 fatty acids

  • Pomegranate juice

  • Vitamin D


A naturopathic perspective

Vitamin D and Cancer Prevention

Vitamin D supplementation reduces all-cancer risk by 60%

(by 78%, if supplementation continued for more than 1 year)

Lappe, JM, D. Travers-Gustafson, K.M. Davies, R.R. Recker and R.P. Heaney. Am J ClinNutr. 2007 Jun; 856: 1586-1591


Fish oil omega 3 fats

Fish Oil (omega 3 fats)

  • Research shows effective in prevention and trx

  • Key anti-inflammatory

  • Omega 6 fats: increaseinflammation


Management of hormone therapy side effects

Management of Hormone Therapy Side Effects

  • Diet (focus on eating lots of F&V, whole grains)

  • Black cohosh; increased intake of soy; Vit E and hesperidin

  • Homeopathics (sepia, pulsatilla, apis)

  • Avoidance of triggers


A naturopathic perspective

In Summary…

Foundations of Health and Healing

Conventional Medical Therapies

Complementary Therapies

Vitamins and Supplements

Sleep, Rest and Relaxation

Exercise

Healthful Water

Healthful Diet

Avoidance of Physical Toxins

Stress Reduction

Emotional Connection

Body-Mind Awareness

Personal Autonomy

Joy and Laughter

Spiritual Connection

Hope

Will to Live


A naturopathic perspective

Thank you!

Any Questions?….


A naturopathic perspective

Optimal Integrative Care

Not Routinely Provided

  • Only 15-19% of cancer survivors meet even the minimal standards for healthful diet (7 or more servings of fruit and vegetables per day).

  • Only 30-47% meet minimum activity targets.

  • Only 5% of cancer survivors meet minimum standards for diet, exercise and smoking.


A naturopathic perspective

Yellow Coat:

High riskcancer,diabetesobesity

Reduced lifespan

Agouti Mouse


A naturopathic perspective

Maternal Supplementswith folate / B12.

Yellow Coat:

Brown Coat:

High riskcancer,diabetesobesity

Lower riskcancer,diabetesobesity

Reduced lifespan

Prolonged life

Agouti MiceSamegenes /DNA


A naturopathic perspective

Cancer as a Turning Point by Dr. Lawrence LeShan

Psychologist working with cancer patients for over 35 yrs.

Majority of patients: Loss of hope in ever achieving a meaningful and satisfying way of living previous to first signs of cancer. When cancer patients were encouraged to explore avenues for bringing meaning, fulfillment and joyinto their lives, they often became well.


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