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RADIOBIOLOGY: PART TWO. CELLULAR EFFECTS OF IRRADIATION . Instant death Reproductive death Apoptosis, programmed cell death(interphase death) Mitotic or genetic death Mitotic Delay Interference of Function Chromosome Breakage. Survival curves for Mammalian Cells .

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cellular effects of irradiation

CELLULAR EFFECTS OF IRRADIATION

Instant death

Reproductive death

Apoptosis, programmed cell death(interphase death)

Mitotic or genetic death

Mitotic Delay

Interference of Function

Chromosome Breakage

survival curves for mammalian cells
Survival curves for Mammalian Cells
  • Shoulder indicates an area of cellular repair with Low LET exposures
cell radiosensisitivy and law of bergonie and tribondeau
Blood cells

Epithelial tissue

Muscle Tissue

Nervous Tissue

Reproductive cells

Blood Cells ???

Find the dose for

Whole body hematologic depression

What are stem or precursor cells?

What dose moderately to severely deplete bone marrow cells?

What are the most sensitive stems cells of human tissue?

Cell radiosensisitivy and Law of Bergonie and Tribondeau
blood cells more questions
Is death caused from high doses to red blood cells or white blood cells or platelets?Why?

What is the lethal dose for humans?

What dose level can impact lymphocytes and why is it so low?

Why are radiation patients monitored

Blood Cells -MORE QUESTIONS
slide6
Epithelial tissue

Muscle Tissue

Nervous Tissue

Radiosensitive

Insenstive

When are nerve cells most sensitive?

reproductive cells
Mature spermatogonia-sensitive or insensitive? Why?

What dose can cause temporary sterility in male? In female?

What dose can cause permanent sterility in male? In female?

Mature ova sensitive or insensitive?

What dose may suppress male sperm population?

When are a woman’s ovaries most sensitive?

Reproductive cells
stochastic
STOCHASTIC
  • Random
  • “all or nothing”
  • linear,nonthreshold
  • playing the lottery
deterministic effect
Deterministic Effect
  • AKA nonstochastic or certainty effect
  • Nonlinear threshold curve
  • threshold assumed
  • increases with severity of dose
dose linear curves pg 112 in sherer pg 498 499 bushong
Dose Linear Curves (PG 112 in Sherer, Pg.498-499 Bushong)
  • Linear, non-threshold
  • Linear threshold
  • Nonlinear (Curvilinear, Sigmoid) Threshold curve
  • Non-linear, non threshold curve
  • Linear Quadratic Non threshold
slide14
AGE
  • The age of the biological structure determines sensitivity
  • Bergonie and Tribondeau
  • Embryo-fetus-newborn-young child
  • Decreases in late teens
  • Stabilizes until old age
  • increases in old age
gender
GENDER
  • Females tolerate 5-15% more
recovery
RECOVERY
  • Cell can recover if sufficient time is given between irradiation
  • some cells have greater capacity for repair
  • Sufficient radiation causes atrophy
slide17

REVIEWPRINCIPLES OFRADIOBIOLOGY ARE BUILT ON THE FOLLOWING:1)RANDOM NATURE2)RADIATION INTERACTS AT CELLULAR LEVEL3)FACTORS THAT ALTER THESE INTERACTIONS

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