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RADIOBIOLOGY: PART TWO. CELLULAR EFFECTS OF IRRADIATION . Instant death Reproductive death Apoptosis, programmed cell death(interphase death) Mitotic or genetic death Mitotic Delay Interference of Function Chromosome Breakage. Survival curves for Mammalian Cells .

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Cellular effects of irradiation

CELLULAR EFFECTS OF IRRADIATION

Instant death

Reproductive death

Apoptosis, programmed cell death(interphase death)

Mitotic or genetic death

Mitotic Delay

Interference of Function

Chromosome Breakage


Survival curves for mammalian cells
Survival curves for Mammalian Cells

  • Shoulder indicates an area of cellular repair with Low LET exposures


Cell radiosensisitivy and law of bergonie and tribondeau

Blood cells

Epithelial tissue

Muscle Tissue

Nervous Tissue

Reproductive cells

Blood Cells ???

Find the dose for

Whole body hematologic depression

What are stem or precursor cells?

What dose moderately to severely deplete bone marrow cells?

What are the most sensitive stems cells of human tissue?

Cell radiosensisitivy and Law of Bergonie and Tribondeau


Blood cells more questions

Is death caused from high doses to red blood cells or white blood cells or platelets?Why?

What is the lethal dose for humans?

What dose level can impact lymphocytes and why is it so low?

Why are radiation patients monitored

Blood Cells -MORE QUESTIONS


Epithelial tissue blood cells or platelets?Why?

Muscle Tissue

Nervous Tissue

Radiosensitive

Insenstive

When are nerve cells most sensitive?


Reproductive cells

Mature spermatogonia-sensitive or insensitive? Why? blood cells or platelets?Why?

What dose can cause temporary sterility in male? In female?

What dose can cause permanent sterility in male? In female?

Mature ova sensitive or insensitive?

What dose may suppress male sperm population?

When are a woman’s ovaries most sensitive?

Reproductive cells


Stochastic
STOCHASTIC blood cells or platelets?Why?

  • Random

  • “all or nothing”

  • linear,nonthreshold

  • playing the lottery


Deterministic effect
Deterministic Effect blood cells or platelets?Why?

  • AKA nonstochastic or certainty effect

  • Nonlinear threshold curve

  • threshold assumed

  • increases with severity of dose


Dose linear curves pg 112 in sherer pg 498 499 bushong
Dose Linear Curves (PG 112 in Sherer, Pg.498-499 Bushong) blood cells or platelets?Why?

  • Linear, non-threshold

  • Linear threshold

  • Nonlinear (Curvilinear, Sigmoid) Threshold curve

  • Non-linear, non threshold curve

  • Linear Quadratic Non threshold


AGE blood cells or platelets?Why?

  • The age of the biological structure determines sensitivity

  • Bergonie and Tribondeau

  • Embryo-fetus-newborn-young child

  • Decreases in late teens

  • Stabilizes until old age

  • increases in old age


Gender
GENDER blood cells or platelets?Why?

  • Females tolerate 5-15% more


Recovery
RECOVERY blood cells or platelets?Why?

  • Cell can recover if sufficient time is given between irradiation

  • some cells have greater capacity for repair

  • Sufficient radiation causes atrophy


REVIEW blood cells or platelets?Why?PRINCIPLES OFRADIOBIOLOGY ARE BUILT ON THE FOLLOWING:1)RANDOM NATURE2)RADIATION INTERACTS AT CELLULAR LEVEL3)FACTORS THAT ALTER THESE INTERACTIONS


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