RADIOBIOLOGY: PART TWO. CELLULAR EFFECTS OF IRRADIATION . Instant death Reproductive death Apoptosis, programmed cell death(interphase death) Mitotic or genetic death Mitotic Delay Interference of Function Chromosome Breakage. Survival curves for Mammalian Cells .
RADIOBIOLOGY: PART TWO
CELLULAR EFFECTS OF IRRADIATION
Apoptosis, programmed cell death(interphase death)
Mitotic or genetic death
Interference of Function
Blood Cells ???
Find the dose for
Whole body hematologic depression
What are stem or precursor cells?
What dose moderately to severely deplete bone marrow cells?
What are the most sensitive stems cells of human tissue?
Is death caused from high doses to red blood cells or white blood cells or platelets?Why?
What is the lethal dose for humans?
What dose level can impact lymphocytes and why is it so low?
Why are radiation patients monitored
When are nerve cells most sensitive?
Mature spermatogonia-sensitive or insensitive? Why?
What dose can cause temporary sterility in male? In female?
What dose can cause permanent sterility in male? In female?
Mature ova sensitive or insensitive?
What dose may suppress male sperm population?
When are a woman’s ovaries most sensitive?
REVIEWPRINCIPLES OFRADIOBIOLOGY ARE BUILT ON THE FOLLOWING:1)RANDOM NATURE2)RADIATION INTERACTS AT CELLULAR LEVEL3)FACTORS THAT ALTER THESE INTERACTIONS