Cholinoceptor activating drugs. M.R. Zarrindast. Cholinergic Receptors: Where are they? . Postganglionic parasympathetic neuroeffector junctions All autonomic ganglia At the neuromuscular endplate. Cholinergic Receptors: Types. Muscarinic receptors Nicotinic receptors
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Cholinoceptor activating drugs
Based on selective activation and antagonism.
Esters of Choline
1. simple alcohols (edrophonium)
2. carbamic acid esters (neostigmine)
3. organophosphates (isoflurophate)
*Look up the pathogenesis of myasthenia gravis
More selective than agonists; may block muscarinic or nicotinic receptors selectively
block the action of Ach and similar agonists at nicotinic receptors at both sympathetic and parasympathetic ganglia