Pathophysiology of Atherosclerosis. Dr Geer Mohammad Ishaq Senior Assistant Professor Department of Pharmaceutical Sciences University of Kashmir. Atherosclerosis.
Pathophysiology of Atherosclerosis
Dr Geer Mohammad Ishaq
Senior Assistant Professor
Department of Pharmaceutical Sciences
University of Kashmir
For the exclusive use of Kashvarsity e-group members
Major risk factors
1)Major Constitutional risk factors:
i. Ageii. Sexiii. Genetic factors
iv. Familial and racial factors
2) Major Acquired risk factors:
i. Hyperlipidaemiaii. Hypertension
iii. Diabetes mellitusiv. Smoking
Minor Risk Factors:
3.Hormones: Oestrogen deficiency, oral contracep.
6.Infections (C. pneumoniae, Herpes virus, CMV)
8.Role of Alcohol
FAMILIAL AND RACIAL FACTORS
Hypercholesterolaemia has directly proportionate relationship with atherosclerosis and IHD because:
6. Infections particularly Clamydia pneumoniae and viruses such as herpesvirus and cytomegalovirus increases coronary atherosclerotic lesions.
7. Patients with homocystinuria, an inborn error of metabolism have early athr and CAD.
8. Moderate consumption of alcohol has slightly beneficial effect by raising the level of HDL cholesterol and by causing vasodilation.
9.However persistent consumption of alcohol in large quantities causes more damage.
Put forth by Virchow in 1852 stating that Ath is a form of cellular proliferation of the intimal cells resulting from increased imbibing of lipids from the blood. Earlier known as “lipid theory” is now called “response to injury hypothesis” and is the most widely accepted theory.
Put forth by Rokitansky in 1852 stating that atheroma represented a form of encrustation on the arterial wall from the components in the blood forming thrombi composed of platelets, fibrin and leucocytes, and was earlier named as “thrombogenic theory”.
3. Role of Blood Monocytes
4. Role of Hyperlipidaemia