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Diagnosis and Management of Gout

Objectives. To review the etiology and pathophysiology of gout To recognize predisposing factors for goutTo review diagnostic criteria and evaluation for goutTo select appropriate treatment for a patient presenting with gout.. Gout. IntroductionEtiology ? Primary vs secondarygoutEpidemiology ?

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Diagnosis and Management of Gout

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    1. Diagnosis and Management of Gout Sadeq AL-Shmesawy

    2. Objectives To review the etiology and pathophysiology of gout To recognize predisposing factors for gout To review diagnostic criteria and evaluation for gout To select appropriate treatment for a patient presenting with gout.

    3. Gout Introduction Etiology – Primary vs secondarygout Epidemiology – Age, gender and race Pathophysiology Predisposing factors Associated conditions Presentation – History, PE, Lab, and Radiology work-up Differential Diagnosis Treatment Summary – pharmacologic – Non-pharmacologic.

    4. Definition Gout is a heterogeneous disorder that results in the deposition of uric acid salts and crystals in and around joints and soft tissues or crystallization of uric acid in urinary tract. Uric acid is the normal end product of the degradation of purine compounds. - Major route of disposal is renal excretion - Humans lack the enzyme uricase to break down uric acid into more soluble form. • Metabolic Disorder underlying gout is hyperuricemia. - Define as 2 SD above mean usually 7.0 mg/dL. This concentration is about the limit of solubility for (monosodium urate) MSU in plasma. At higher levels, the MSU is more likely to precipitate in tissues.

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