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Chem 108: Lab Week 16

Chem 108: Lab Week 16. Sign in / Pick up Papers and Handouts. Wordsearch Due Today. Chem 108 Synthesis of Aspirin. Report Form Due Today Weighing Aspirin Product & % Yield. Representing Organic Molecules Aspirin. http://chemconnections.org/general/movies/Representations.MOV.

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Chem 108: Lab Week 16

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  1. Chem 108: LabWeek 16 Sign in / Pick up Papers and Handouts

  2. Wordsearch Due Today

  3. Chem 108Synthesis of Aspirin Report Form Due Today Weighing Aspirin Product & % Yield

  4. Representing Organic MoleculesAspirin http://chemconnections.org/general/movies/Representations.MOV

  5. Chem 108Synthesis of Aspirin

  6. Mass Calculations: Reactants Products • How many grams of aspirin are theoretically produced from 6.0 g of salicylic acid with an excess of acetyl chloride, C2H3OCl? • Balanced Equation: 1 1 1 1

  7. Mass Calculations: Reactant Product • How many grams of aspirin are theoretically produced from 6.0 g of salicylic acid with an excess of acetyl chloride, C2H3OCl? • Balanced Equation: 1 1 1

  8. Mass Calculations: Reactants Products

  9. Theoretical (Yield) Mass Calculations Reactant Product grams (Reactant) grams (Product) Moles Molar Mass Stoichiometry grams (P) 1 mol (R) grams (R) ? mol (P) ? grams (P) ? mol (R) grams (R) 1 mol (P) (Divide) Mass (R) (Multiply) Mass (P) by Molar "Gatekeepers” from Balanced reaction by Molar

  10. Mass Calculations: A SA grams (Salicylic Acid) grams (Aspirin) Moles C9H8O4 MW = 180.15 Molar Mass Stoichiometry grams (A) (Molecular 1 mol (SA) 6.0 grams (SA) 1 mol A Weight A) ? (A) 1 mol SA grams (SA) 1 mol (A) 7.8 g aspirin (Molecular Weight SA) "Gatekeeper" C7H6O3MW = 138.12

  11. Percent Yield • In synthesis as in any experiment, it is very difficult and at most times impossible to be perfect. Therefore the actual yield (g) is measured and compared to the theoretical calculated yield (g). This is the percent yield: • % Yield = actual (g) / theoretical (g) x 100

  12. QUESTION • A synthetic reaction produced 2.45g of Ibogaine, C20H26N2O, a natural product with strong promise in treating heroin addiction (at least in Europe), the calculated theoretical yield was 3.05g, what is the % yield? A) 19.7% B) 39.4% C) 80.3% D) 160.6%

  13. QUESTION • How many grams of aspirin are theoretically produced from 5.0 g of salicylic acid reacting with an excess of acetic anhydride, C4H6O3? • Balanced Equation: A) 3.8 g B) 5.0 g C) 6.5 g D) 7.8 g

  14. QUESTION • Noelle’s synthesis of aspirin, C9H8O2, produced 5.90g. The calculated theoretical yield was 6.50g; what is her % yield? A) 47.5% B) 80.3% C) 90.6% D) 110%

  15. Weigh filtered crude aspirin & calculate % yield. Turn in Report Form with partner’s names. • Experiment uses acetic anhydride (C4H6O3)

  16. Wordsearch Due Today

  17. Chem 108 Week 16 Organic Molecules Lipids: fats, oils, waxes, terpenes(C5x-carbon formulas), eg. steroids

  18. Lipids:Fats & Oils Lipids are natural plant & animal products more soluble in non-polar solvents like gasoline than in water. Combustion (burning) of one gram: of carbohydrate produces 4 to 5 Calories, protein produces 4 to 5 Calories, fat produces 9 to 10 Calories — more than twice that of either sugars or proteins.

  19. Food Pyramid, April 2016

  20. The human body is 60-70 percent water, blood is ~90 percent, the brain and muscles are ~75 percent , and bones are ~20 percent by mass. * A human can survive for a month or more without eating food, but only 1-2 weeks without drinking water. How much energy is required to raise the water in your body from 25oC (average room temperature) to 37oC (average body temperature [that is, chemical -biological temperature])? Assume that there is the equivalent of 5 liters of water, d = 1.0 g/mL in your body. The heat capacity of water is 4.184 J/g oC (1.00 cal /g oC); (0.001 Cal / g oC); (0.001 kcal /g oC) How many grams of fat would need to be burned? (9 Cal/g)

  21. How much energy is required to raise the water in your body from 25oC (average room temperature) to 37oC (average body temperature [that is, chemical -biological temperature])? Assume that there is the equivalent of 5 liters of water, d = 1.0 g/mL in your body. The heat capacity of water is 4.184 J/g oC (1.00 cal /g oC); (0.001 Cal / g oC); (0.001 kcal /g oC) How many grams of fat would need to be burned? (9 Cal/g) (37o - 25oC)* 5,000 mL * 1.0 g/mL * 4.184 J/g oC = 250 kJ = 60 Cal 60 Cal / 9 Cal/g = 6.7 g … but how long does it last before you need more?

  22. Steroids • What is cholesterol? • Is there such a thing as “good” vs. “bad” cholesterol? • How does it relate to fat?

  23. Structures of selected steroids. (Sex hormones and synthetic compounds that have similar actions.)

  24. http://www.cbsnews.com/videos/russias-dark-secret/ Anabolic Steroids

  25. Question • The backbone structure of cephalosporin P is classified as a • A) fatty acid. B) steroid. • C) cholesterol. D) amino acid.

  26. Chem 108Week 16 Amino Acids & Proteins Handout Turn in beads & form today Then pick up albumin

  27. Summary blue H2N- red -CO2H

  28. Chem 108Week 16 Amino Acids & Proteins (egg albumin) Handout Report & Post Lab Questions Due Next Lab http://chemconnections.org/general/chem108/Protein%20Activity%20I-2016.html

  29. Cooking the perfect egg: denaturing albumin perfectly softboiled http://chemconnections.org/general/chem106/Tech%20Prep/Protein%20Activity%20I-2016.html

  30. ½ inch H2O; Boil; Insert raw egg; Cover; Reduce heat to low; Steam for 6.5 min (No more, no less); Remove & put in cold H2O; Peel egg; Enjoy. Ham, capuccino & cinnamon toast optional.

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