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Macronutrients in Pregnancy 2008. Carbohydrate Protein Lipids. 2002 DRI for Carbohydrate. DRIs for carbohydrate based on brain glucose utilization RDA for adults and children = 130 g/day Median intake ~: Men: 200-330 g/day Women: 180-230 g/day. 2002 DRI for Carbohydrate in Pregnancy.

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slide2
Carbohydrate
  • Protein
  • Lipids
2002 dri for carbohydrate
2002 DRI for Carbohydrate
  • DRIs for carbohydrate based on brain glucose utilization
  • RDA for adults and children = 130 g/day
  • Median intake ~:
    • Men: 200-330 g/day
    • Women: 180-230 g/day
2002 dri for carbohydrate in pregnancy
2002 DRI for Carbohydrate in Pregnancy
  • Fetal brain needs a minimum of 33 g/day
  • EAR for pregnancy (all ages) = 135 g/day
  • RDA for pregnancy (all ages) = 175 g/day
    • CV is 15% based on variations in brain glucose utilization
    • RDA = EAR plus twice CV

CV: coefficient of variation (used when insufficient data to determine standard deviation)

EAR: Estimated Average Requirement

2002 dri for fiber in pregnancy
2002 DRI for Fiber in Pregnancy
  • “There is no evidence to suggest the beneficial effects of fiber in reducing risk of CHD is different from non-pregnant adolescent girls and women.”
  • AI = 28 g/day (14 g/1,000 kcal x median kcal intake for group)
  • AI for non-pregnant women is 25 g/day
effect of a low glycemic index diet during pregnancy on obstetric outcomes moses et al ajcn 2006
Effect of a low-glycemic-index diet during pregnancy on obstetric outcomes(Moses et al. AJCN 2006)
  • 62 women randomized to counseling to promote low GI (LGI) or moderate/high GI (HGI)
  • Outcomes for HGI diet:
    • Higher birthweight (3408 vs 3644)
    • Higher prevalence LGA (3% vs 33%)
  • Conclusion: “Because birth weight and ponderal index may predict chronic disease in later life, a low-GI diet may favorably influence long-term outcomes.”
slide8
Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitusZhange et al. Diabetes Care, 2006
  • Examined prepregnancy diet in the Nurses Health study (758 pregnancies in 13,110 women over 8 years), adjusted for age, parity, prepregnancy BMI, and other covariates
  • Results
    • Each 10-g/day increment in total fiber intake was associated with 26% (95% CI 9-49) reduction in risk of GDM
    • Each 5-g/day increment in cereal or fruit fiber was associated with a 23% (9-36) or 26% (5-42) reduction, respectively.
    • Dietary glycemic load was positively related to GDM risk. Multivariate relative risk for highest versus lowest quintiles was 1.61 (1.02-2.53) (P for trend 0.03).
slide9

The dietary glycemic index during pregnancy: influence on infant birth weight, fetal growth, and biomarkers of carbohydrate metabolismScholl et al, Am J Epi, 2004)

  • n=1082, very low income, mostly young, ethnic minorities in Camden NJ
  • women with a dietary glycemic index in the lowest quintile had approximately a twofold increased risk of bearing a growth-restricted infant compared to middle quintile (AOR = 1.75 (1.10, 2.77)
ear for protein in pregnancy
EAR for Protein in Pregnancy
  • EAR = 21 g/day above protein needs at prepregnancy weight
  • EAR Per kg
    • Increased amount on a per kg basis is 0.22 g/protein/kg/day
    • EAR for non-pregnant = 0.66 g protein/kg per day
    • EAR for pregnancy = 0.88 g/kg/day
rda for protein for pregnancy
RDA for Protein for Pregnancy
  • 1.1 g/kg/day or 25 g/day additional protein (EAR plus allowance for individual variation)
  • RDA for women aged 19-50 is 46 g/day
  • RDA is 71g protein per day

Reference woman is 57 kg

rda to diet
RDA to Diet
  • RDAs calculated using high quality reference proteins like egg, meat, milk or fish
  • However, even with adjustments for lower quality proteins most women in the US who are meeting energy needs with reasonable food choices, will meet protein needs.
    • Range in US is 75 to 110 g per day for women.
energy and protein
Energy and Protein
  • If energy needs are not met by diet then protein will be used for energy
  • RDA calculations assume adequate energy intake
protein supplementation
Protein Supplementation
  • In developing countries protein and energy supplements may improve pregnancy outcomes when women are undernourished
  • There is little evidence that protein supplementation affects outcome in developed countries
adverse effects of protein supplementation
Adverse Effects of Protein Supplementation
  • Several human and animal studies of protein supplementation have found adverse effects including retarded fetal growth, increase in prematurity, and increased neonatal deaths.
cochrane collection energy and protein intake in pregnancy kramer et al 2004
Cochrane Collection: Energy and Protein Intake in Pregnancy (Kramer et al, 2004)
  • objectives: To assess the effects of advice to increase or reduce energy or protein intake, or of actual energy or protein supplementation or restriction during pregnancy on energy and protein intakes, gestational weight gain, and the outcome of pregnancy
cochrane collection high protein supplementation in pregnancy
Cochrane Collection: High protein supplementation in pregnancy
  • Selection criteria: acceptably controlled trials of dietary advice to increase or reduce energy or protein intake, or of actual energy or protein supplementation or restriction, during pregnancy.
results dietary advice to increase energy and protein intakes
Results: dietary advice to increase energy and protein intakes
  • 5 trials, 1134 women
  • Dietary advice increased intakes
  • No consistent benefit was observed for pregnancy outcomes
results balanced energy protein supplementation
Results: Balanced Energy/Protein Supplementation
  • 13 trials, 4665 women
  • Modest increase in maternal weight gain and mean birth weight
  • Reduction risk for SGA
  • Reduced risk of stillbirth and neonatal death
  • No significant effects on preterm birth
results high protein supplementation
Results: High Protein Supplementation
  • Two trials, 1076 women
  • Small, nonsignificant increase in maternal weight gain and nonsignificant reduction in birth weight
  • Increased risk of SGA
  • Nonsignificant increased risk of neonatal death
results energy protein restriction for overweight women
Results: Energy/protein restriction for overweight women
  • 3 trials, 384 women
  • Reduced maternal weight gain
  • Reduced mean birth weight
  • No effect on pregnancy induced hypertension or pre-eclampsia
lipids
Lipids
  • General lipid recommendations for pregnancy
  • Essential fatty acids & LCPUFA
  • Trans FA
lipids maternal
Lipids: Maternal
  • Metabolism changes to:
    • meet increased maternal needs for energy and hormones precursors
    • to insure adequate fetal accretion
  • Serum cholesterol rises 25-40%
  • Triglycerides rise 200-400%
lipids maternal recommendations 2002 dri
Lipids: Maternal Recommendations, 2002 DRI
  • 30% of kcals from fat is a reasonable goal in pregnancy.
    • There is no need to try to affect the physiological rise in blood lipids
background lcpufa
Background: LCPUFA
  • Dietary sources of n-3 and n-6 fatty acids are essential.
  • Fetal ability to elongate and desaturate fatty acids is limited.
  • Conversion of LNA to DHA is highly variable among individual infants.
fetal implications
Fetal Implications
  • Human brain is lipid based; ~ 60% of dry weight
  • 30% of fetal CNS tissue is LCPUFA with n-3 to n-6 ratio of 2:1
  • Fetal brain development starts early & experiences “growth spurt” during last trimester and 1st 6 months of life
  • In 3rd trimester, storage of LCPUFA in fetal adipose tissue if adequate maternal sources
  • Adequacy of LCPUFA associated with CNS and retinal function.
background placental transfer
Background: Placental Transfer
  • The fetus is totally dependent on maternal intake and placental transfer.
  • The placenta selectively transports LCPUFA
  • Concentrations of DHA and ARA are 300 to 400 fold higher in fetal vs maternal plasma phospholipids
maternal lcpufa status maters to the infant
Maternal LCPUFA status maters to the Infant
  • Women with higher plasma ARA and DHA during pregnancy have infants with higher ARA and DHA
  • Higher n-6 and n-3 status at birth results in higher ARA and DHA for several weeks.
slide36
Dunstan et al. Pediatr Res, 2007. Fish oil supplementation in pregnancy on breastmilk FA composition over the course of lactation
  • RCT, n=98, Fish oil (s.2.g DHA, 1.1 g EPA) vs olive oil from 20 wk to term
  • Breastmilk had higher DHA & EPA at 3 d and 6 weeks
  • Infants had higher DHA/EPA at 1 yr
  • Positive correlations between breastmilk DHA/EPA and infant developmental scores
maternal lcpufa status matters to the pregnancy
Maternal LCPUFA Status matters to the Pregnancy
  • Eicosanoids derived from LCPUFA (prostaglandins, thromboxanes, prostacylcins, leukotrienes) play vital roles in pregnancy
  • The ideal ratio of n-3 to n-6 remains unknown
  • Dietary sources of EFA - both n-3 and n-6 are important
pih and n 3 fatty acids
PIH and n-3 Fatty Acids
  • Possible biological pathway:
    • Vasoconstriction and epithelial damage of PIH is associated with imbalance of TXA2 (vasoconstrictor) and PGI2 (vasodilator)
  • If increased dietary intake of n-3:
    • EPA competes with Arachadonic Acid for enzymes so may have lower production of TXA2 and higher production of PGI3 (vasodilator)
pih and n 3 fatty acids39
PIH and n-3 Fatty Acids
  • Epidemiological Studies:
    • several studies have found that women with PIH have lower levels of n-3
    • lower incidence of PIH in fish eating populations
  • RCT
    • “Compelling evidence for a beneficial effect of n-3 fatty acids on preeclampsia from recent prospective, double-blind studies is lacking (Jensen, Am J Clin Nutr, 2006)
n 3 and prolonged gestation
N-3 and Prolonged Gestation
  • Faroe Islands:
    • high birthweights
    • longer gestations
    • diet high in marine oils
  • Theory: n-3 interference with uterine prostaglandin production
n 3 and prolonged gestation42
N-3 and Prolonged Gestation
  • Supplementation study:
    • increased gestational length by 4 days
    • prolonged bleeding times & increased blood loss at delivery
n 3 and maternal depression jensen ajcn 2006
N-3 and Maternal Depression (Jensen, AJCN, 2006)
  • “Recent observational trials and open-label trials of n-3 FA supplementation appears promising.”
  • “At present, however, there is a paucity of data from controlled studies supporting the efficacy of n-3 FA in the prevention or treatment of depression during pregnancy or the postpartum period.”
n 3 intake and depression by country hibbeln ajcn 2006
N-3 intake and Depression by Country (Hibbeln, AJCN, 2006)
  • In model with 20 countries, correlation between postpartum depression rates and energy from n-3 FA was r=-0.78, p<0.001)
infant visual function neural development jensen 2006
Infant visual function/neural development (Jensen, 2006)
  • Observational studies find both positive associations and no association.
  • Small intervention studies: possible associations with attention & distractibility and visual functioning.
essential fatty acids in mothers and their neonates hornstra ajcn 2000
Essential Fatty Acids in Mothers and Their Neonates(Hornstra, AJCN, 2000)
  • Maternal essential fatty acid status declines during pregnancy (absolute plasma levels in-crease, but non-essential increase more).
  • Pregnancy may cause maternal DHA depletion/mobilization from maternal stores. (Implications for close pregnancy spacing)
slide48
Essential PUFA status of newborns is restricted by that of the mother and may not be optimal.
  • Maternal PUFA supplementation affects neonatal PUFA status.
  • Maternal linoleate intake during pregnancy is negatively related to neonatal head circumference.
  • In preterm infants positive relationship between DHA in umbilical artery and birth weight. Length, and OFC.
hornstra implications
Hornstra - Implications
  • Humans evolved with limited ability to elongate and desaturate EFA?
  • Limitations require special consideration during increased requirements of fetal development, lactation, and neonatal development.
slide50
Hibbeln et al. Maternal seafood consumption in pregnancy & neurodevelopmental outcomes in childhood. Lancet 2007
  • Maternal seafood consumption of less than 340 g per week in pregnancy did not protect children from adverse outcomes; rather, we recorded beneficial effects on child development with maternal seafood intakes of more than 340 g per week, suggesting that advice to limit seafood consumption could actually be detrimental. These results show that risks from the loss of nutrients were greater than the risks of harm from exposure to trace contaminants in 340 g seafood eaten weekly.
washington state fish advisory for mercury for women of childbearing age and children under six
Washington State Fish Advisory for Mercury for Women of Childbearing Age and Children Under Six
  • Do not eat any shark, swordfish, tilefish, king mackerel or either fresh caught or frozen tuna steaks.
  • Limit the amount of canned tuna you eat, based on your bodyweight. General guidelines are:
    • Women of childbearing age should limit the amount of canned tuna they eat to about one can per week (six ounces).
    • Children under six should eat less than one half a can of tuna (three ounces) per week. Specific weekly limits for children under six range from one ounce for a twenty pound child, to three ounces for a child weighing about sixty pounds.
    • Choose chunk light tuna over albacore white to further reduce your exposure to mercury.
    • Find out about fish advisories.

http://www.doh.wa.gov/fish/FishAdvMercury.htm

slide52
For freshwater bass:
    • Woman of childbearing age and children under six should limit their consumption of freshwater bass (largemouth and smallmouth) to no more than 2 meals/month.  Additional information can be obtained from the "Statewide Bass Advisory"  report and the "Freshwater Largemouth and Smallmouth Bass Consumption Advisory Due to Mercury Contamination" fact sheet
slide53
Health problems caused by mercury are:
    • Babies whose mothers ate fish contaminated with mercury during pregnancy, are at greater risk for changes to their nervous systems.  These changes can affect their ability to learn.
health problems cont
Health problems, cont.
  • In adults, several neurological signs and symptoms are among the common features of chronic high-dose exposures to methylmercury in adults. These can include peripheral neuropathy (tingling in the hands and feet), tremor, problems walking, dizziness, visual and hearing difficulties, and memory impairment (NRC 2000, ATSDR 1999). These symptoms are generally not associated with the level of exposure to methylmercury through the consumption of fish in the U.S. Mercury has been shown to accumulate in the heart. Recent findings investigating chronic low-dose exposures have been associated with changes in blood-pressure and abnormal heart function (Salonen et al. 1995, Sorensen et al 1999) as well as increased risk of heart-attack (Guallar et al. 2002).
what about other contaminants
What about other contaminants?
  • Mercury in fish is a big concern, but fish might also contain other contaminants. Some kinds of pesticides and chemicals called "PCBs" also get into fish. PCBs and pesticides are mostly found in the skin and fatty part of fish, so if you cut and cook fish in ways that remove the skin and fat, you can lower the amount of pesticides and PCBs in your food.
recent recommendations for fish intake in pregnancy
Recent Recommendations for Fish Intake in Pregnancy
  • Consumer Reports, July 2006:
    • “Given the uncertainties about the safety of even chunk-light tuna, we think it’s prudent for pregnant women to avoid canned tuna entirely.”
    • Women of childbearing age who aren’t pregnant: “Mercury can linger in the body after you stop eating fish, so we advise these women to eat no more than about 3 chunk-light cans per week or one can of solid-light or white tuna.”
what about salmon
What about Salmon?
  • Foran et al. Journal of Nutrition, 2005
  • Risk Benefit Ratios
  • Benefit carcinogenic risk ratio (BCRR)
  • Benefit noncarcinogenic risk ratio (BNRR)
  • In general Wild salmon:
    • have low contaminant contributions
    • have lower levels of n-3 FA
slide60

Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction,(Cochran Collaboration, 2006)

  • Six trials, involving 2783 women
  • Results for pregnancies randomized to supplements:
    • Mean gestation 2.6 days longer
    • Lower risk of birth <34 weeks (RR=0.69, 0.49-0.99)
    • Birthweight slightly greater (47 g)
    • no overall differences between the groups in the proportion of LBW or SGA babies
    • No clear difference RR of pre-eclampsia between the two groups
  • Conclusion: “There is not enough evidence to support the routine use of marine oil, or other prostaglandin precursor, supplements during pregnancy to reduce the risk of pre-eclampsia, preterm birth, low birthweight or small-for-gestational age.”
allergies and n 3 fa
Allergies and n-3 FA
  • Animal models and limited human studies indicate potential beneficial impact of n3 FA on allergy prevention and immuno-modulation.(Blumer, J perinatl med, 2007)
michael crawford director institute for brain chemistry and human nutrition london
Michael Crawford, Director, Institute for Brain Chemistry and Human Nutrition, London
  • http://www.seafoodandhealth.org/index.php?section=20&id=277

“…the brain case of this little one-year-old fellow is nearly the same size as the mother’s. What that tells you is that the priority of human development is the brain; it’s not the body. Look at the size of the child’s hand compared to the mother’s. We know all about this, and I’m not going to dwell on it, but the priority is unquestionably, in homo sapiens, the brain. Physiological requirement is the brain, nutritional requirement priority is the brain, and the brain is made of lipids, so we’ve got to get these lipids to make our brains.’

key points of crawford s presentation
Key Points of Crawford’s Presentation
  • Humans evolved and thrived near water

with access to DHA

  • EU report that cost of “brain disorders” has overtaken all other costs of ill health and there are predictions that mental health will be in the top three burdens of ill health for the world by 2020
  • We need to restore the food chain to give better balance of n-3 to n-6
  • We need to invest in the ocean
ralston seafood health conference 200566
Ralston, Seafood & Health Conference, 2005

http://www.seafoodandhealth.org/index.php?section=20&id=279

essential fatty acids requirements in pregnancy
Essential Fatty Acids Requirements in Pregnancy
  • FAO recommends 4.5% of daily energy as EFA (essential fatty acids) in pregnancy and 6% in lactation
    • If kcals are inadequate energy based recommendations may be misleading
2002 dri for n 6 fatty acids in pregnancy
2002 DRI for n-6 Fatty Acids in Pregnancy
  • AI = 13 g/day linoleic acid
  • Based on median linoleic acid intake of pregnant women in US where deficiency is “basically non-existent.”
  • AI for non-pregnant women = 12 g/day
2002 dri for n 3 fatty acids in pregnancy
2002 DRI for N-3 Fatty Acids in Pregnancy
  • Demand driven by:
    • fetus
    • placental tissue
    • secretion during lactation
  • AI = 1.3 g/day of a-linolenic acid
    • Based on median a-linolenicacid intake of pregnant women in US where deficiency is “basically non-existent.”
    • non-pregnant AI=1.1 g/day a-linolenic acid
    • DHA and EPA can contribute toward total n-3
trans fatty acids
Trans Fatty Acids
  • Side product of catalytic hydrogenation of vegetable oils and biohydrogenation in the rumen of animals
  • Animal studies show discrimination against transport of trans FA across the placenta, but some are transported.
  • Trans FA inhibit elongation of EFA
  • Trans FA in plasma of human preterm infants was found to be inversely associated with LCPUFA
emerging issues73
Emerging Issues
  • trans unsaturated fats may increase the risk of ovulatory infertility (Chavarro, AJCN, 2007)
  • birth length (BL) and head circumference (HC) were significantly and negatively related to the C18:1trans concentration in phospholipids isolated from umbilical plasma (HC), umbilical arterial walls (HC and BL), or umbilical venous walls (BL). (Hornstra, Atherosclerosis Supplements, 2006)
trans fatty acids74
Trans Fatty Acids
  • Infant formula has few trans FA, breastmilk content reflects maternal diet.
  • What to recommend?
trans fatty acid policy
Trans Fatty Acid & Policy

“These considerations support strategies to effectively remove TFA from industrial sources from the diet of pregnant and lactating women, and young children, while improving dietary intakes of the n − 3 fatty acids. .”

Innis, Atherosclerosis Supplements, 2006

macronutrient status
Macronutrient Status
  • Important throughout the reproductive years:
    • Periconceptual period
    • Pregnancy
    • Lactation
    • Inter-pregnancy interval
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