Curtis jt and wang z neuroscience 2005 presented by yvonne pao october 31 2008
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Curtis, JT and Wang, Z. Neuroscience, 2005. Presented by: Yvonne Pao October 31, 2008 PowerPoint PPT Presentation


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GLUCOCORTICOID RECEPTOR INVOLVEMENT IN PAIR BONDING IN FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS. Curtis, JT and Wang, Z. Neuroscience, 2005. Presented by: Yvonne Pao October 31, 2008. REWARD PROCESSING AND PAIR BOND FORMATION.

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Curtis, JT and Wang, Z. Neuroscience, 2005. Presented by: Yvonne Pao October 31, 2008

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Curtis jt and wang z neuroscience 2005 presented by yvonne pao october 31 2008

GLUCOCORTICOID RECEPTOR INVOLVEMENT IN PAIR BONDING IN FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

Curtis, JT and Wang, Z. Neuroscience, 2005.

Presented by: Yvonne Pao

October 31, 2008


Reward processing and pair bond formation

REWARD PROCESSING AND PAIR BOND FORMATION

Insel, TR 2003


Pair bonding in prairie voles

PAIR BONDING IN PRAIRIE VOLES


Neurochemicals in pair bonding

NEUROCHEMICALS IN PAIR BONDING

  • Corticosterone: adrenal stress hormone; activates glucocorticoid receptors (GR)

    • Thought to enhance reward value

  • Opposing effects in males and females:

    • Adrenalectomy in females enhancement of pair bond formation

    • Adrenalectomy in males  inhibition of pair bond formation

      Is decreased GR activation rewarding in females?


Experiment 1

EXPERIMENT 1

  • Reduce glucocorticoid receptor activation in female prairie voles via injection

  • Pair female with male for 6 hr non-sexual habitation

  • Test females for partner preference


Experiment 11

EXPERIMENT 1

Aragona and Wang 2008


Experiment 1 results

EXPERIMENT 1: RESULTS


Experiment 2

EXPERIMENT 2

  • Pair bonds enhanced after GR blockade

     GR blockade is rewarding in females?

  • Hypothesis

    • GR blockade interacts with central dopamine systems (D1 and D2) of the “reward circuitry”

  • Approach

    • Pre-treat females with dopamine receptor antagonists before RU-486 treatment

    • Observe behavioral effects


Experiment 2 results

EXPERIMENT 2: RESULTS


Conclusions

CONCLUSIONS

  • Acute blockade of MRs and GRs facilitates pair bond formation in females

  • Acute reduction of GR activation increases reward value of male

  • Dopamine receptor antagonists can inhibit the effect of GR antagonists


Discussion gr blockade and pair bonding

DISCUSSION: GR BLOCKADE AND PAIR BONDING

  • Activation of GR and MRs produce opposing actions on different measures of other species

  • RU-486 and spironolactone have anti-gonadal effects

    • Enhanced pair bonding does not seem to result from these effects

  • Spironolactone treatment affects other behaviors

    • Suggests it acts centrally

    • Greatest concentration of MR found in hippocampus, which may alter activity of ventral tegmental area (VTA)


Discussion gr interaction with dopamine

DISCUSSION: GR INTERACTION WITH DOPAMINE

  • D1 and D2 blockade antagonizes GR blockade by RU-486

  • Effects of D1 receptor blockade were unexpected:

    • Previous studies indicate D1 blockade does not interfere with mating-induced partner preference

    • Mating and pair bonding involve different mechanisms?

  • Effects of D2 receptor were expected:

    • Has been found to play major role in pair bonds

    • Social stress alters dopamine release in NAcc (also implicated in prairie vole pair bonding)

       Corticosterone interact with dopamine in NAcc


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