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ADAPT Update. AfriCan Forum Entebbe, 17-19 January 2013. A African D Development of A AIDS P Prevention T Trials Capacity. Goal of ADAPT: Build local capacity so that Africans can plan, conduct and analyse large scale, multi-centred AIDS prevention trials.

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adapt update

ADAPT Update

AfriCan Forum

Entebbe, 17-19 January 2013

slide2

A African

D Development of

A AIDS

P Prevention

T Trials

Capacity

slide3

Goal of ADAPT:

Build local capacity so that Africans can plan, conduct and analyse large scale, multi-centred AIDS prevention trials

lack of prevention evidence from rcts
Lack of prevention evidence from RCTs

More than 6000 HIV prevention studies published between 2000 and end of 2012

Less than 300 were RCTs

slide7

Second phase

First phase

2007-2009

2010-2014

first course participants
First course participants
  • 23 researchers from 11 African countries
  • Botswana, Lesotho, Malawi, Mozambique, Namibia, Nigeria, South Africa, Swaziland, Tanzania, Zambia, Zimbabwe
  • From government (via NAAs), universities, and NGOs
slide11

Left HIV prevention work and joined a bank

Moved from NGO to National AIDS Authority

Prominent in National AIDS Authorities

Elected – became Minister – NAA in remit

With CIET in Nigeria – on faculty for next course

Head of department in University

Promoted within research organisation

Post-doctoral fellowship

Completing MSc Epidemiology and Statistics

Coordinating CIET work in Botswana

slide12

ADAPT presentations at AIDS impact conference

Who has multiple concurrent sexual partnerships in Botswana?

Results of a national cross sectional survey.

Laetsang D, Ho-Foster A, Masisi M, Anderson M, Tlhoiwe D, Cockcroft A, Andersson N

Community views of inter-generational sex: findings from focus groups

in Botswana, Namibia and Swaziland.

Kunda JL, Kgakole L, Cockcroft A, Masisi M, Laetsang D, Ho-Foster A, Marokoane N, Andersson N

Characteristics and attitudes of the choice-disabled in Namibia.

Van Rooy G, Mitchell S, Masisi M, Cockcroft A, Andersson N

Socio-economic status and HIV and AIDS stigma in Tanzania.

Mbaraka A, Mitchell S, Cockcroft A, Andersson N

Choice disability and HIV prevention knowledge, attitudes

and practices in Botswana.

Ho-Foster A, Andersson N, Cockcroft A, Masisi M, Laetsang D, Kgakole L

What has happened to multiple sexual partnerships in Swaziland

between 2002 and 2008?

Cockcroft A, Andersson N, Ho-Foster A, Marokoane N, Mziyako B

slide13

ADAPT publications in peer reviewed journals

Ho-Foster A, Laetsang D, Masisi M, Anderson M, Tlhoiwe D, Cockcroft A, Andersson N..

Gender-specific patterns of multiple concurrent sexual partnerships:

a national cross sectional survey in Botswana.

AIDS Care 2010: 1-6 (doi: 10.1080/09540121003758598)

Cockcroft A, Lengwe KundaJ, Kgakole L, MasisiM, Laetsang D, Ho-Foster A,

Marokoane N, Andersson N.

Community views of inter-generational sex:

findings from focus groups in Botswana, Namibia and Swaziland.

Psychology, Health and Medicine 2010 (in press)

Amuri B, Mitchell S, Cockcroft A, Andersson N.

Socio-economic status and HIV and AIDS stigma in Tanzania.

AIDS Care 2010 (in press)

Cockcroft A, Andersson N, Ho-Foster A, Marokoane N, Mziyako B

What happened to multiple sexual partnerships in Swaziland?

Analysis of five linked national surveys between 2002 and 2008.

AIDS Care 2010: 1-6 (doi: 10.1080/09540121.2010.482123)

second course
Second course
  • Nominations from SADC NAAs
  • 1st three week block 28 Jan–15 Feb 2013
  • 20 participants:
    • 4 Botswana, 1 Mauritius, 3 Namibia, 4 Swaziland, 2 Tanzania, 2 Zambia, 4 Zimbabwe
  • Epidemiology and statistics relevant to RCTs
  • Support to develop fundable HIV prevention research proposals
research topics
Research topics
  • Multiple concurrent partnerships in young women
  • HIV risks in female sex workers
  • Sexual behaviour after male circumcision
  • Sexual behaviour among college students
  • Condition cash transfers and HIV trial
  • HIV infection through breastfeeding
  • Role of older people in youth HIV prevention
systematic review module
Systematic review module
  • 16-20 July 2012
  • School of Nursing and Public Health, UNAM
  • 10 participants – mostly SNPH faculty
systematic review module1
Systematic review module
  • Methods of analysis of RCTs
  • RCTs and non-experimental study designs
  • Elements of SR and meta-analysis
    • data extraction
    • dealing with heterogeneity between studies
    • interpretation of forest plots
    • assessment of quality of studies and SRs
systematic review module2
Systematic review module
  • Practical experience
    • navigating Cochrane website
    • searching literature
    • using Revman software to conduct meta analysis
systematic review module3
Systematic review module

The Dean of the SNPH presented certificates on the final day

slide20

Capacity building for Botswana parliamentarians

Participants in the first session – November 2011

botswana parliamentarians
Botswana parliamentarians

Evidence-based decision making

Two training sessions

  • 31 October/1 November 2011
  • 12 and 14 November 2012

Logistic organisation by NACA

Attended by

  • 36 of 61 MPs
  • Including 7 ministers
laboratory skills training
Laboratory skills training

National Institute for Communicable Diseases, Johannesburg, S Africa

  • Two SADC one-week courses:
  • HIV serology on dried blood spots
  • New techniques for estimating HIV incidence

Participants:

>With basic laboratory skills

challenges
Challenges
  • Retaining trained individuals in system
  • Organisations not allowing time out for higher qualifications
  • SADC bureaucracy (laboratory courses)
  • Obtaining funding for African led research
by end of adapt
By end of ADAPT
  • Network of trained HIV researchers in SADC countries
  • Improved institutional capacities for research
  • Several fundable proposals for RCTs led by African researchers
  • Better informed and equipped decision makers
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