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Novel Drug Delivery in Pediatric Medulloblastoma

Novel Drug Delivery in Pediatric Medulloblastoma. Group 37 – Arvin Soepriatna (Presenter), Chris Peng , Blessan Sebastian Client: Mr. Mike Sabo, Pulse Therapeutics, Inc. BME 401, Prof. Anastasio 10/28/2013. Need.

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Novel Drug Delivery in Pediatric Medulloblastoma

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  1. Novel Drug Delivery in Pediatric Medulloblastoma Group 37 – Arvin Soepriatna (Presenter), Chris Peng, Blessan Sebastian Client: Mr. Mike Sabo, Pulse Therapeutics, Inc. BME 401, Prof. Anastasio 10/28/2013

  2. Need • More efficient treatment process regarding drug delivery with chemotherapeutic agents • Currently no method to exclusively target tumors • Chemotherapy side effects are serious • Increased drug dosage without side-effects • Shorter and more effective treatment time

  3. Specific Design Requirements

  4. Phantom Designs • Box Obstacle Course • 3D Styrofoam Brain Phantom • Blood Vessel Phantom

  5. Magnetic Control Device • Cartesian • Conical • Spherical

  6. Advantages and Disadvantages

  7. Imaging Technology Alternatives • Positron Emission Tomography (PET) • Measures γ-rays emission from radioactive tracer[1] • Half-life of tracers[2] • 13N ~ 20 min. • 18F ~ 110 min. • Recent discoveries • 64Cu ~ 12.7 hours [3] • Nanoparticle conjugation [1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print. [2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013. [3] Anderson, Carolyn J., FarrokhDehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.

  8. Imaging Technology Alternatives • Single Photon Emission Computed Tomography (SPECT) • Similar to PET • γ-rays emission • Radioactive tracer • Average half-lives ~6 hours[1] • Difference from PET[2] • Lower resolution • High Noise [1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013. [2] Rahmim, Arman, and HabibZaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.

  9. Imaging Technology Alternatives • Doppler Ultrasound • Measures the time it takes for pulse signals to be returned to the receiver from its generation.[1] • High resolution images • Problem: • Distortion through thick bones[2] • High signal to noise ratio • Transcranial Ultrasound • Suboccipital Window [3] [1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print. [2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print. [3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.

  10. Imaging Technology Alternatives • Spectral Computed Tomography (CT) • Measures X-ray attenuation coefficient • Utilizes photon counting detectors [1] • Broad spectrum info from X-ray • Lower dosage of X-ray • High Resolution [1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral CT Images. 2011. Web. 26 Oct. 2013.

  11. Advantages and Disadvantages [1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print. [2] Rahmim, Arman, and HabibZaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.

  12. Chosen Design • Magnetic Control Device: Conical Movement • Imaging Technology: Transcranial Doppler Ultrasound

  13. Phantom • Styrofoam thickness: 3cm • Model skull + brain • IV tubing Diameter: 0.5 cm • CSF = 0.7 – 1.0 mPa*s @37oC[1] • Saline = 0.72 mPa*s[2] • Pathway fixtures • Plastic hooks • Thin plastic cable wires [1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science Business Media, 2011. p. 139. eBook. [2] Kestin, Joseph, H. EzzatKhalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys. Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.

  14. Conical Magnetic Control Device • Joint modification of the machine made by Pulse Therapeutics • Motor specs for joints • 300 Watts • Motor specs for rotating magnet • Up to 300 RPM

  15. Peak Voltage Output of Magnet • Voltage measured using 3D magnetic transducer probe

  16. Doppler Ultrasound • Location of transducer • Angle of incidence • Properties of transducer • For adults[1] • 3-MHz transducers • For pediatric • 5-MHz transducers [1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013. Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.

  17. Project Timeline

  18. Team Organization

  19. Thank you for listening!

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