Novel drug delivery in pediatric medulloblastoma
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Novel Drug Delivery in Pediatric Medulloblastoma. Group 37 – Arvin Soepriatna (Presenter), Chris Peng , Blessan Sebastian Client: Mr. Mike Sabo, Pulse Therapeutics, Inc. BME 401, Prof. Anastasio 10/28/2013. Need.

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Novel Drug Delivery in Pediatric Medulloblastoma

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Novel drug delivery in pediatric medulloblastoma

Novel Drug Delivery in Pediatric Medulloblastoma

Group 37 – Arvin Soepriatna (Presenter), Chris Peng,

Blessan Sebastian

Client: Mr. Mike Sabo, Pulse Therapeutics, Inc.

BME 401, Prof. Anastasio

10/28/2013


Novel drug delivery in pediatric medulloblastoma

Need

  • More efficient treatment process regarding drug delivery with chemotherapeutic agents

    • Currently no method to exclusively target tumors

    • Chemotherapy side effects are serious

  • Increased drug dosage without side-effects

  • Shorter and more effective treatment time


Specific design requirements

Specific Design Requirements


Phantom designs

Phantom Designs

  • Box Obstacle Course

  • 3D Styrofoam Brain Phantom

  • Blood Vessel Phantom


Magnetic control device

Magnetic Control Device

  • Cartesian

  • Conical

  • Spherical


Advantages and disadvantages

Advantages and Disadvantages


Imaging technology alternatives

Imaging Technology Alternatives

  • Positron Emission Tomography (PET)

    • Measures γ-rays emission from radioactive tracer[1]

    • Half-life of tracers[2]

      • 13N ~ 20 min.

      • 18F ~ 110 min.

    • Recent discoveries

      • 64Cu ~ 12.7 hours [3]

      • Nanoparticle conjugation

[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.

[2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.

[3] Anderson, Carolyn J., FarrokhDehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.


Imaging technology alternatives1

Imaging Technology Alternatives

  • Single Photon Emission Computed Tomography (SPECT)

    • Similar to PET

      • γ-rays emission

      • Radioactive tracer

        • Average half-lives ~6 hours[1]

    • Difference from PET[2]

      • Lower resolution

      • High Noise

[1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.

[2] Rahmim, Arman, and HabibZaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.


Imaging technology alternatives2

Imaging Technology Alternatives

  • Doppler Ultrasound

    • Measures the time it takes for pulse signals to be returned to the receiver from its generation.[1]

    • High resolution images

    • Problem:

      • Distortion through thick bones[2]

      • High signal to noise ratio

    • Transcranial Ultrasound

      • Suboccipital Window [3]

[1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.

[2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.

[3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.


Imaging technology alternatives3

Imaging Technology Alternatives

  • Spectral Computed Tomography (CT)

    • Measures X-ray attenuation coefficient

    • Utilizes photon counting detectors [1]

      • Broad spectrum info from X-ray

      • Lower dosage of X-ray

    • High Resolution

[1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral CT Images. 2011. Web. 26 Oct. 2013.


Advantages and disadvantages1

Advantages and Disadvantages

[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.

[2] Rahmim, Arman, and HabibZaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.


Chosen design

Chosen Design

  • Magnetic Control Device: Conical Movement

  • Imaging Technology: Transcranial Doppler Ultrasound


Phantom

Phantom

  • Styrofoam thickness: 3cm

    • Model skull + brain

  • IV tubing Diameter: 0.5 cm

    • CSF = 0.7 – 1.0 mPa*s @37oC[1]

    • Saline = 0.72 mPa*s[2]

  • Pathway fixtures

    • Plastic hooks

    • Thin plastic cable wires

[1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science Business Media, 2011. p. 139. eBook.

[2] Kestin, Joseph, H. EzzatKhalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys. Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.


Conical magnetic control device

Conical Magnetic Control Device

  • Joint modification of the machine made by Pulse Therapeutics

  • Motor specs for joints

    • 300 Watts

  • Motor specs for rotating magnet

    • Up to 300 RPM


Peak voltage output of magnet

Peak Voltage Output of Magnet

  • Voltage measured using 3D magnetic transducer probe


Doppler ultrasound

Doppler Ultrasound

  • Location of transducer

    • Angle of incidence

  • Properties of transducer

    • For adults[1]

      • 3-MHz transducers

    • For pediatric

      • 5-MHz transducers

[1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.

Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.


Project timeline

Project Timeline


Team organization

Team Organization


Thank you for listening

Thank you for listening!


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