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Novel Drug Delivery in Pediatric Medulloblastoma. Group 37 – Arvin Soepriatna (Presenter), Chris Peng , Blessan Sebastian Client: Mr. Mike Sabo, Pulse Therapeutics, Inc. BME 401, Prof. Anastasio 10/28/2013. Need.

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novel drug delivery in pediatric medulloblastoma

Novel Drug Delivery in Pediatric Medulloblastoma

Group 37 – Arvin Soepriatna (Presenter), Chris Peng,

Blessan Sebastian

Client: Mr. Mike Sabo, Pulse Therapeutics, Inc.

BME 401, Prof. Anastasio

10/28/2013

slide2
Need
  • More efficient treatment process regarding drug delivery with chemotherapeutic agents
    • Currently no method to exclusively target tumors
    • Chemotherapy side effects are serious
  • Increased drug dosage without side-effects
  • Shorter and more effective treatment time
phantom designs
Phantom Designs
  • Box Obstacle Course
  • 3D Styrofoam Brain Phantom
  • Blood Vessel Phantom
magnetic control device
Magnetic Control Device
  • Cartesian
  • Conical
  • Spherical
imaging technology alternatives
Imaging Technology Alternatives
  • Positron Emission Tomography (PET)
    • Measures γ-rays emission from radioactive tracer[1]
    • Half-life of tracers[2]
      • 13N ~ 20 min.
      • 18F ~ 110 min.
    • Recent discoveries
      • 64Cu ~ 12.7 hours [3]
      • Nanoparticle conjugation

[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.

[2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.

[3] Anderson, Carolyn J., FarrokhDehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.

imaging technology alternatives1
Imaging Technology Alternatives
  • Single Photon Emission Computed Tomography (SPECT)
    • Similar to PET
      • γ-rays emission
      • Radioactive tracer
        • Average half-lives ~6 hours[1]
    • Difference from PET[2]
      • Lower resolution
      • High Noise

[1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.

[2] Rahmim, Arman, and HabibZaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.

imaging technology alternatives2
Imaging Technology Alternatives
  • Doppler Ultrasound
    • Measures the time it takes for pulse signals to be returned to the receiver from its generation.[1]
    • High resolution images
    • Problem:
      • Distortion through thick bones[2]
      • High signal to noise ratio
    • Transcranial Ultrasound
      • Suboccipital Window [3]

[1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.

[2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.

[3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.

imaging technology alternatives3
Imaging Technology Alternatives
  • Spectral Computed Tomography (CT)
    • Measures X-ray attenuation coefficient
    • Utilizes photon counting detectors [1]
      • Broad spectrum info from X-ray
      • Lower dosage of X-ray
    • High Resolution

[1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral CT Images. 2011. Web. 26 Oct. 2013.

advantages and disadvantages1
Advantages and Disadvantages

[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.

[2] Rahmim, Arman, and HabibZaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.

chosen design
Chosen Design
  • Magnetic Control Device: Conical Movement
  • Imaging Technology: Transcranial Doppler Ultrasound
phantom
Phantom
  • Styrofoam thickness: 3cm
    • Model skull + brain
  • IV tubing Diameter: 0.5 cm
    • CSF = 0.7 – 1.0 mPa*s @37oC[1]
    • Saline = 0.72 mPa*s[2]
  • Pathway fixtures
    • Plastic hooks
    • Thin plastic cable wires

[1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science Business Media, 2011. p. 139. eBook.

[2] Kestin, Joseph, H. EzzatKhalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys. Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.

conical magnetic control device
Conical Magnetic Control Device
  • Joint modification of the machine made by Pulse Therapeutics
  • Motor specs for joints
    • 300 Watts
  • Motor specs for rotating magnet
    • Up to 300 RPM
peak voltage output of magnet
Peak Voltage Output of Magnet
  • Voltage measured using 3D magnetic transducer probe
doppler ultrasound
Doppler Ultrasound
  • Location of transducer
    • Angle of incidence
  • Properties of transducer
    • For adults[1]
      • 3-MHz transducers
    • For pediatric
      • 5-MHz transducers

[1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.

Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.

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