Motor neuron disease
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Motor neuron disease. Motor Neurone Disease. Definition: It is a degenerative disease of a gradual onset and progressive course, affecting the motor system only (systemic disease). (corticospinal tract+ anterior horn cell) UMN signs LMN signs. Motor neuron disease.

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Motor neuron disease

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Motor neuron disease


Motor Neurone Disease

  • Definition:

    It is a degenerative disease of a gradual onset and progressive course, affecting the motor system only (systemic disease).


(corticospinal tract+ anterior horn cell)

UMN signs LMN signs

Motor neuron disease


Clinical Picture

  • Age of onset:

  • Sex:

  • Onset and Course:

  • Signs and symptoms:


I-U.M.N. Affection

  • a) In the spinal cord:

  • Spastic paraplegia if the lesion is below the cervical region, or

  • Spastic quadriplegia if the lesion is at the cervical region.


  • b)In the brain stem or the cerebral hemisphere:

    1.Bulbar symptoms:

    - dysphagia.- nasal regurgitation.

    - dysarthria.- hoarseness of voice.


II- L.M.N. Affection


Motor Neurone Disease

I- U.M.N.L.

II- L.M.N.L.

a-Brain Stem

“True Bulbar

Palsy

a-Brain Stem

“Pseudo-bulbar palsy

b-Spinal Cord

“Progressive Muscular Atrophy”

b-Spinal Cord

“Lateral Sclerosis


III-Combined U.M.N and L.M.N Affection

Syndrome of :

"amyotrophic lateral sclerosis“

There are combined signs and symptoms of lower and upper motor neurone lesions


Amyotrophic Lateral Sclerosis


Diagnosis

  • ALS is difficult to diagnose because it has similar symptoms of other neuromuscular disorders. Some of the procedures include:

    Magnetic resonance imaging (MRI)


Treatment


1- Avoid fatigue and exhaustion.

2- Massive doses of vit. E and B.

3- Anabolics.

4-Physiotherapy,respiratory care,swallowing,….


Prevention


thanks


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