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Nanotechnology in Favour of Medical Imaging

Mohammad Tavakoli 4 th Mini-Seminar in Physiology of Brain & Cognition Instructor: Dr. Gharibzadeh Spring 2008. Nanotechnology in Favour of Medical Imaging. Nowadays Hi-techs. Atomic Technology: Concerning Energy Biotechnology & Stem Cells: Concerning Life & Health IT:

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Nanotechnology in Favour of Medical Imaging

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  1. Mohammad Tavakoli 4th Mini-Seminar in Physiology of Brain & Cognition Instructor: Dr. Gharibzadeh Spring 2008 Nanotechnology in Favour of Medical Imaging

  2. Nowadays Hi-techs • Atomic Technology: • Concerning Energy • Biotechnology & Stem Cells: • Concerning Life & Health • IT: • Concerning Information • Nanotechnology: • Concerning Very Small Things ;)

  3. Nano • How small would it be? • Millimeter: • Wavelength of microwaves • Micrometer: • One millionth of a meter • Nanometer: • One thousand millionth of a meter • Angstrom: • Hundred-millionth of a centimeter or 10-10 meter • Wavelength of light: 400 to 700 nanometers or .4-.7 Å

  4. Any Problem? • Submicroscopic things and phenomenon are not visible in analytical manner! • Brownian motion in fluids -> Chaotic Environment • So What? • Computational Science • Prof. Rafii-Tabar (IPM) • Simplification & Idealization • Numerical Modeling (Abstract) & Computer Simulation • Supercomputers & Parallel Processing • Physics of Nanotechnology: 10-15 sec. & 10-7 -10-9 m.

  5. Nano Scale Devices • Scanning Tunneling Microscopy (STM) • IBM (1980) • Simulations @ IBM website, e.g. Nano-tubes • Atomic Force Microscopy (AFM) • Seeing like a blind person • Magnetic Resonance Force Microscopy • The technique used here is same as MRI • Academic researches

  6. AFM (Touching Microscopy) • In AFM, a sharp probe is scanned across a surface, left, and by monitoring the motion of the probe from each pass across the surface, a 2-D line profile is generated. • Then the line profiles are combined to create a three dimensional image of the surface, right.

  7. Educational Devices

  8. Related Software • Quantum: • Gaussian • Wein2K • Spresso • GPMD • Molecular Dynamics: • NAMD • Visualization: • AVS • VMD (Visual Molecular Dynamics)

  9. What is the Use? • Nanomagnetic Structures for Atomic Resolution MRI • Nanowire-based sensor for ultra-high sensitivity magnetic resonance force microscopy • Amplification of magnetic flux in magnetic resonance by magnetic nanoparticles that promises to significantly improve MRI performance

  10. MRI Problems? • Problem 1: • In 2001 a patient in a British hospital died of heart failure shortly after being given an MRI brain scan! • Solution: • “Nano-coated implants cut MRI scan dangers” 2003 • Problem 2: • How can we improve the MRI resolution? • Solution: Contrast Agents • What can Nanotechnology do here?

  11. MRI Problems? • Solution: • Superparamagnetic contrast agents (e.g. iron oxidenanoparticles) have become available. • These agents appear very dark on T2*-weighted images and may be used for liver imaging - normal liver tissue retains the agent, but abnormal areas (e.g. scars, tumors) do not. • They can also be taken orally, to improve visualization of the gastrointestinal tract, and to prevent water in the gastrointestinal tract from obscuring other organs (e.g. pancreas).

  12. MRI Improvement with Nanoparticles

  13. The End

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