Laboratory automation integrating equipment into a multi vendor world
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Laboratory Automation Integrating equipment into a multi-vendor world. INTRODUCTION. INTEGRATION. SCHEDULING. SMALL SYSTEMS. HIGH THROUGHPUT SYSTEMS. DATA HANDLING. SUMMARY. Programme. Laboratory Automation Integrating equipment into a multi-vendor world Introduction. Malcolm Crook

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Laboratory Automation Integrating equipment into a multi-vendor world

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Laboratory automation integrating equipment into a multi vendor world

Laboratory Automation Integrating equipmentinto a multi-vendor world


Programme

INTRODUCTION

INTEGRATION

SCHEDULING

SMALL SYSTEMS

HIGH THROUGHPUT SYSTEMS

DATA HANDLING

SUMMARY

Programme


Laboratory automation integrating equipment into a multi vendor world introduction

Laboratory Automation Integrating equipmentinto a multi-vendor world Introduction


Your presenter

Malcolm Crook

Synthetic chemist

12 years in industry (BP)

19 years in automation

11 years running PAA

25 years writing software

Visiting Reader in Chemistry at University of Surrey

Your Presenter


Laboratory automation integrating equipment into a multi vendor world integration

Laboratory Automation Integrating equipmentinto a multi-vendor world Integration


What do paa offer

What do PAA offer

  • Scheduling software

    • OVERLORD™ Workstation

    • OVERLORD™ Scheduler

  • Systems integration expertise

  • Data handling expertise

    • links to LIMS

    • links to databases

  • wide range of peripherals


Perkinelmer products

Plate

readers

Pipettingrobots

PerkinElmer products


Robots

Robots


Mitsubishi

Dextrous gripper

Long reach

Dynamic vertical reach

Mitsubishi


Laboratory automation integrating equipment into a multi vendor world scheduling

Laboratory Automation Integrating equipmentinto a multi-vendor world Scheduling


Scheduling

Scheduling

Two types:

  • Real time scheduling

    • All decisions are taken during the time frame of the run

    • i.e. once the “GO” button is pressed

  • Pre-emptive scheduling

    • All decisions are taken before the run starts

    • i.e. before the “GO” button is pressed


Real time scheduling

Real time scheduling

  • Advantages:

    • flexible

    • decisions can be taken during the run

    • error recovery easy

  • Disadvantages

    • accurate timings are more difficult to set up

    • two accurate timings in a run are impossible


Pre emptive scheduling

Pre-emptive scheduling

  • Advantages:

    • one or more accurate timings are guaranteed

    • easy to set up

  • Disadvantages

    • inflexible

    • decisions can not be taken during the run

    • error recovery more difficult


Scheduling the choice

Scheduling - the choice

real-time

pre-emptive

either


Laboratory automation integrating equipment into a multi vendor world1

Laboratory Automation Integrating equipmentinto a multi-vendor world


Our automated systems

Our Automated Systems

  • complete solution using existing equipment

  • complete integration with other equipment

  • complete integration of hardware / software

  • integrated data handling


Features

FEATURES

  • PC based, Windows 2000/XP

  • full password and user identification

  • full interfacing with LIMS via text files

  • icon based, flow chart interface

  • on-line context sensitive manual

  • drag and drop setup

  • European language support


Overlord

OVERLORD™

  • flow diagrams

  • hierarchical control

  • interface

  • instrument control

  • general functionality

  • connection to the outside world

  • 21CFR user access

  • expandability


Flow diagrams

flow diagrams

  • Natural method of experiment description

  • easy to understand

  • easy to explain to another

  • easy to check logic


Laboratory automation integrating equipment into a multi vendor world

comment

N = 3 loops

N = 3

Loop for n

samples

Action 1

Action 2

N = N + 1

Next

sample

All done


Laboratory automation integrating equipment into a multi vendor world

comment

Loop for n

samples

Action 1

Action 2

Next

sample

All done


Hierarchical control

hierarchical control

  • Organised programming

  • logical units of operations

  • reusable procedures


Overlord1

Main control loop

procedural unit 2

procedural unit 3

procedural unit 1

sub unit 1

sub unit 2

sub unit 3

etc ....

OVERLORD™


Overlord2

Run sample

preparation loop

procedural unit 2

procedural unit 3

dilute sample

Pick sample plate

from hotel

Place on

Hamilton

Pick blank plate

from hotel

etc ....

OVERLORD™


Interface

interface

  • flow diagram analogue

  • automatically filled in to aid programming

  • interface follows Microsoft visual specifications


Laboratory automation integrating equipment into a multi vendor world

Information header about procedure

Body of actions in procedure

End of procedure

Values & description at runtime

Scroll around the procedure


Laboratory automation integrating equipment into a multi vendor world

Palette of available commands

Toolbar of common functions


Laboratory automation integrating equipment into a multi vendor world

Information header about procedure

Branching on condition

Robot action

tooltips to aid interpretation


Laboratory automation integrating equipment into a multi vendor world

List of procedures

for overview of complete

method


Instrument control

Instrument control

  • any device that can be controlled by

    • serial communications

    • switch on/off

    • variable voltage

  • use of equipment native control software

    • with automation interface

    • without automation interface


Runtime

Runtime

  • full self documentation/audit trail

  • data storage on server/local disc

  • clear, easy to read runtime interface


Laboratory automation integrating equipment into a multi vendor world

Laboratory Automation Integrating equipmentinto a multi-vendor world Example of real time scheduling 1


Plate reading

Plate reading

  • Process a stack of plates

  • pass through a plate reader

  • collate the results


Laboratory automation integrating equipment into a multi vendor world

Matrix PlateMate Plus

Hudson Plate Crane

Bulk dispenser

Plate washer

Plate reader


Laboratory automation integrating equipment into a multi vendor world

Laboratory Automation Integrating equipmentinto a multi-vendor world Example of real time scheduling 2


Laboratory automation integrating equipment into a multi vendor world

MultiPROBE

SWAP robot


Laboratory automation integrating equipment into a multi vendor world

PlateSTAK


Laboratory automation integrating equipment into a multi vendor world

PlateSTAK


Laboratory automation integrating equipment into a multi vendor world

Laboratory Automation Integrating equipmentinto a multi-vendor world Example of pre-emptive scheduling


Laboratory automation integrating equipment into a multi vendor world

Toolbar of common functions

Start with new assay for schedule

Information header about procedure


Laboratory automation integrating equipment into a multi vendor world

Start with plate types in assay


Laboratory automation integrating equipment into a multi vendor world

Fill in the assay name

Drag and drop the actions

in the assay


Laboratory automation integrating equipment into a multi vendor world

Fill in the actions


Laboratory automation integrating equipment into a multi vendor world

optimise


Laboratory automation integrating equipment into a multi vendor world

optimise


Laboratory automation integrating equipment into a multi vendor world

Integrating a MultiPROBEII


Integrating a multiprobe ii

Integrating a MultiPROBE II

  • Hit picking

  • batch of plates stored in MolBank

  • process plate for stage on Matrix Platemate plus

  • Instruments

    • Jouan MolBank

    • PerkinElmer MultiPROBE II

    • Hamilton SWAP robot

    • Liconic plate store


Laboratory automation integrating equipment into a multi vendor world

Matrix PlateMate Plus

Liconic storage

MultiPROBE II

MolBank


Laboratory automation integrating equipment into a multi vendor world

Hamilton SWAP

MultiPROBE II


Laboratory automation integrating equipment into a multi vendor world high throughput systems

Laboratory Automation Integrating equipmentinto a multi-vendor world High Throughput Systems


System integration

System integration

  • Same as all the other systems we have described

  • OVERLORD™ software control package

  • ability to use ‘large’ instruments


High throughput systems

high throughput systems

  • single computer control

  • same OVERLORD™ interface

  • maximum use of processing power

  • require maximum throughput

  • requires complex scheduling algorithms

    • expensive

    • complicated

    • difficult to set up


Very high throughput

Very high throughput

  • One PC cannot control everything

  • processor switching on Windows inefficient

    • one instrument 100%

    • two instrument 140% (not 200%)

  • Multiply processor system required


Our answer

Our answer …

  • Distributed processing

  • NetLORD™

  • allows any number of workstations

  • full efficiency of all workstations

  • logical control

  • unsophisticated control required

    • cheap to install

    • easy to understand


Laboratory automation integrating equipment into a multi vendor world

Laboratory Automation Integrating equipmentinto a multi-vendor world High Throughput SystemsAmes II test


Netlord

NetLORD™

  • New concept in multi instrument control

  • uses standard Ethernet protocols

  • full control of instruments over network

  • reduced need for scheduling algorithms

  • uses simple workflow control interface

  • low cost to implement


Advantages

Advantages

  • uses same interface as OVERLORD™

  • PC / piece of equipment ensures throughput

  • no timing problems

  • redundancy can be built into the system


Laboratory automation integrating equipment into a multi vendor world

Indicator addition

Bacteria addition

Platereader

Incubator


Laboratory automation integrating equipment into a multi vendor world

Instructed from

OVERLORD™ server

Control of clients

From 3 PCs

4 PCs

PC

peripherals

KVM

box


Laboratory automation integrating equipment into a multi vendor world data handling

Laboratory Automation Integrating equipmentinto a multi-vendor world Data handling


Communication to the outside world

Input

manual data input

experimental setup

text files, csv

data from LIMS

data from database

Output

report/printer

data file, text file

data to LIMS

data to database

Communication to the outside world


Data handling

Data Handling

Data can be handled with

  • Microsoft EXCEL

  • Microsoft WORD

  • Microsoft VB Scripts

  • Microsoft VB for Applications

  • Microsoft Access

  • Oracle SQL


Excel data setup page

EXCEL - data setup page


Excel

EXCEL


Laboratory automation integrating equipment into a multi vendor world summary

Laboratory Automation Integrating equipmentinto a multi-vendor world Summary


Summary

INTRODUCTION

INTEGRATION

SCHEDULING

SMALL SYSTEMS

HIGH THROUGHPUT SYSTEMS

DATA HANDLING

SUMMARY

Summary


Information

Information

  • PAA web page

    • pictures

    • application notes

    • technical details

    • system descriptions

  • PAA

    • [email protected]

    • +44 1252 373000


  • Login