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Funding Application Plan Zhangli Peng , Ph.D. Nanomechanics Laboratory

Funding Application Plan Zhangli Peng , Ph.D. Nanomechanics Laboratory Department of Materials Science and Engineering Massachusetts Institute of Technology March 11, 2014. Funding Application Plan. NSF (BMMB, PoLS )

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Funding Application Plan Zhangli Peng , Ph.D. Nanomechanics Laboratory

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  1. Funding Application Plan Zhangli Peng, Ph.D. Nanomechanics Laboratory Department of Materials Science and Engineering Massachusetts Institute of Technology March 11, 2014

  2. Funding Application Plan • NSF (BMMB, PoLS) • Project 1: Multiscale Modeling of Cell Transmigration and its Mechanobiology • Project 2: Triple-Decker Concurrent Multiscale Modeling Approach for Solid Mechanics • NIH, DoD, DoE

  3. Biomechanics: Biology (genetics, etc.) Mechanobiology: Mechanical forces Mechanical Properties (modulus, etc.) Biology (protein expression, structure) Objective: To understand the mechanisms of cell transmigration through extracellular matrices and blood vessels, and its mechanobiology. Project 1: MultiscaleModeling of Cell Transmigration and its Mechanobiology 3D transmigration of cancer cells (metastasis)

  4. Biomechanics: Biology (genetics, etc.) Mechanobiology: Mechanical forces Mechanical Properties (modulus, etc.) Biology (protein expression, structure) Objective: To understand the mechanism of cell transmigration through extracellular matrix and blood vessel and its mechanobiology. Project 1: MultiscaleModeling of Cell Transmigration and its Mechanobiology • Biomechanics and Mechanobiology(CMMI, NSF) • Program officer: Dennis Carter • Planned proposal submission: January 15 - February 15 • Physics of Living Systems (Division of Physics, NSF) • Program officer: KrastanBlagoev • Planned proposal submission: January 15 - February 15 Potential collaborations with Prof. Huang, Prof. Chiarot and Prof. Singlerat Binghamton University

  5. Project 1: MultiscaleModeling of Cell Transmigration and Mechanobiology Specific Aims: Aim 1: Multiscale modeling of diseased red blood cells transmigration through human spleens Aim 2: Development of multiscale eukaryotic cell model Aim 3: Modeling of extravasation and intravasation of cancer cells, white blood cells and stem cells Aim 4: Modeling of microfluidic testing of cell transmigration and its mechanobiology Aim 5: Modeling of drug delivery based on cell transmigration

  6. Aim 1: MultiscaleModeling of Diseased Red Blood Cells Transmigration Through Spleen Buffet et al. Blood, 2006

  7. Aim 1: Preliminary Result Experiment Modeling LPC is a drug to induce membrane loss of red blood cells

  8. Aim 2: Development of Multiscale Eukaryotic Cell Model Cell membrane Nucleus Actin filaments Microtubules Intermediate filaments Myosin motors Focal adhesion

  9. Aim 3: Modeling of Extravasation and Intravasationof Cancer Cells,White Blood Cells and Stem Cells 3D transmigration of cancer cells (metastasis) Transmigration of white blood cells

  10. Aim 4: Modeling of Microfluidic Testing of Cell Transmigration and its Mechanobiology Flow Flow Flow

  11. Aim 4: Modeling of Microfluidic Testing of Cell Transmigration and its Mechanobiology Cell compression (acoustic tweezers) Potential collaboration with Prof. Huang, Prof. Chiarot and Prof. Singlerat Binghamton University By coupling FEM/BEM Cancer cell compression

  12. Aim 4: Modeling of Drug Delivery Based on Cell Transmigration Shareiet al. PNAS 2013

  13. Project 2: Triple-Decker Concurrent Multiscale Approach for Solid Mechanics Objective: To develop a triple-decker concurrent multiscale modeling approach to study phenomena in solid mechanics and materials science. FEM PD FEM PD • Mechanics of Materials (CMMI, NSF) • Program officer: Thomas Siegmund • Planned proposal submission: January 15 - February 15

  14. Project 2: Triple-Decker Concurrent Multiscale Approach for Solid Mechanics Specific Aims: Aim 1: Development of triple-decker concurrent multiscale approach for solid mechanics Aim 2: Multiscale modeling of metallic glass Aim 3: Multiscale modeling of aneurysm rupture and fluid-structure interaction Potential collaboration with Prof. Park, Prof. Murray, Prof. Zhou and Prof. Ke at Binghamton University

  15. Aim 1: Development of Triple-Decker Concurrent Multiscale Approach for Solid Mechanics • Peridynamics(PD) simulation of rupture FEM PD FEM PD

  16. Metallic glass cantilever Observed area in TEM × Diamond tip Electron beam Aim 2: MultiscaleModeling of Metallic Glass After 275 cycles Strain 4.8% Gap 10 nm Peridynamics Monotonic loading Strain 8% MD FEM

  17. Aim 3: MultiscaleModeling of Aneurysm Rupture and Fluid-Structure Interaction

  18. Aim 3: MultiscaleModeling of Aneurysm Rupture and Fluid-Solid Interaction Fluid Fluid-solid interaction FEM PD Solid FEM PD

  19. Long-term Funding Application Plan • NIH (to seek collaborations with experimentalists and clinicians) • Cardiovascular diseases (aneurysm, artery dissection) • National Heart, Lung, and Blood Institute (NHLBI) • National Institute of Biomedical Imaging and Bioengineering (NIBIB) • Program officer: Grace Peng • Cancer (transmigration, detecting circulating tumor cells) • National Cancer Institute (NCI) • Dept. of Defense • Psychological Health and Traumatic Brain Injury • Dept. of Energy

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