Hypothalamic-pituitary hormones

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Hypothalamic hormones and analoguesGnRH agonists Buserelin (suprefact) Gonadorelin (Factrel) Goserelin (Zoladex) Histrelin (Supprelin) Leuprolide (Lupron, Lupron Depot, Viadur) Nafarelin (synarel) Triptorelin (Trelstar Depot, Trelstar LA)GnRH Antagonists Abarelix (Plenaxis) Cetr

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Hypothalamic-pituitary hormones

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1. Hypothalamic-pituitary hormones

2. Hypothalamic hormones and analogues GnRH agonists Buserelin (suprefact) Gonadorelin (Factrel) Goserelin (Zoladex) Histrelin (Supprelin) Leuprolide (Lupron, Lupron Depot, Viadur) Nafarelin (synarel) Triptorelin (Trelstar Depot, Trelstar LA) GnRH Antagonists Abarelix (Plenaxis) Cetrorelix (Cetrotide) Ganirelix (Antagon) Dopamine Agonists Bromocriptine (Parlodel) Cabergoline (Dostinex) Somatostatin Analogue Octreotide (Sandostatin, Sandostatin LAR) TRADE NAMES

4. THERAPEUTIC OVERVIEW Hypothalamic hormones GnRH Replacement therapy for idiopathic hypogonadotropic hypogonadism GnRH Analogs Prostate and breast cancer Idiopathic precocious puberty Endometriosis Dopamine Agonists Pathological hyperprolactinemia Acromegaly Parkinsonĺs disease Somatostatin and Analogs Acromegaly Carcinoid and vasoactive intestinal peptide-secreting tumors Pituitary hormones LH and FSH infertility in women Infertility in men with hypogonadotropic hypogonadism GH Adult GH deficiency Growth failure AVP Diabetes insipidus

17. Hypothalamic hormone and analogs GnRH adverse reactions infrequent Occasional nausea headache, abdominal discomfort Anaphylaxis (rare) with IV use Localized problems at injection site Dopamine Nausea, orthostatic agonists Hypotention initially Confusion, hallucinations in Parkinsonĺs disease Somatostatin analogs Hyperglycemia, loose stools, gallstones Pituitary hormones and analogs LH and FSH Multiple gestation Pregnancy, Gynecomastia in men Ocasional febrile reactions GH Antibodies Misues in athletes AVP Nausea, vertigo, headache Anaphylaxis Angina, Myocardial infarction Drug interactions Bromocriptine Phenothiazine or butyrophenones: prevent dopamine agonist action Vasopressin Carbamazepine, analogs chlorpropamide, clofibrate, fludrocortisone, tricyclic antidepressants: potentiate action Lithium, heparin, alcohol: inhibit action

18. Thyroid and antithyroid drugs

19. Therapeutic overview

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