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—— 揭开生命的奥秘 孙 啸 程 璐 PowerPoint PPT Presentation


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第七讲 人类基因组研究. —— 揭开生命的奥秘 孙 啸 程 璐. 人类基因组计划. HGP(Human Genome Projects) 1 、 HGP 简介 2 、 HGP 的主要任务 3 、 HGP 对人类的重要意义 4 、 HGP 进展与未来 5 、 我国对人类基因组计划的贡献 6 、 功能基因组学 7 、 基因组相关的伦理学问题 8 、 HGP 对生物信息学提出挑战. 1 、 HGP 简介.

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—— 揭开生命的奥秘 孙 啸 程 璐

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HGP(Human Genome Projects)

1HGP

2HGP

3HGP

4HGP

5

6

7

8HGP


1 hgp

1HGP

  • 198519903030


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  • Renato Dulbecco1986Science, 231: 10551056

  • DNA


Genome

(Genome)


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HGP

  • 198412UtahAlta,White RDNADNA

  • 19856

  • 19866

  • 1987NIH55019871.66

  • 1989J.Waston

  • 199051011530


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HGP


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HGP


2 hgp

2HGP


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-

  • genetic map(linkage map)1%1%1cM


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  • cM

    1%


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-

  • physical mapDNA


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  • 1998 52,000(STS)


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-


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mRNAcDNAEST


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-

  • DNADNADNA


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Megabace

3700


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  • BAC

  • Celera


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3 hgp

3HGP

HGP


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  • """"


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  • 1997

    ""

    "


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HGP


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HGP


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HGP


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HGP

    • 13

    • 300400

    • 200

    • 20


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HGP


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DNA Report


4 hgp

4HGP

  • 200320012000626


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  • 30 (bp) DNA

  • 3%97%

  • 4 1022 XY


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5

  • 1994HGP863

  • 19981998

  • 1999

  • 19997330Mb1


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1%

  • 199991

  • 199911128631%86330001000

  • 19991129


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1998


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2001

II


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6

  • DNA

    • DNA


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    • mRNA c DNA


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Genetic files 1998 10

(Genetic Files)199810:,


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7


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  • VS

  • VS


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HGP

1

2

3


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DNA

  • DNA

  • 24


8 hgp

8HGP

HGP


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DNA

(SNPs )

5-GGTTTACACCTAA-

5-GTTTTAAACCGAA-

(VNTR - )

5-AATCAATCAATC-

5-AATCAATCAATCAATCAATC--


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DNA

VNTR

8bpDNAVNTR

2-5bpDNASTR


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  • SNP

  • SNP31


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  • DNA


Jeffreys dna

JeffreysDNA

1985

Jeffreys

RFLP

,

DNA


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RFLP?

(Restriction Fragment Length Polymorphism, RFLP)


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DNA

DNA


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DNA

DNA


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DNA

(STR)


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VNTR


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STR

2-3 3-3 2-4


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STR

2-3 3-4 2-4


D8s384

D8S384

7-9 5-7 5-8 5-10 6-11 8-11 7 9


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PI

TH01 9-10 9-10 9-10 1.8904

VWA17-1716-18 16-17 3.3113

FES11-1311-11 11-13 2.6882

D19S400 12-1212-13 12-13 2.0263

D19S25311-1212-13 11-13 5.2521

D8S117913-18 14-15 15-18 12.6263

D21S1409 7-710-11 7-102.5157

D21S2055 17-2018-26 17-18 4.2315

D5S818 7-9 8-10 8-9 2.3545

D7S820 6-10 7-7 6-7 3.3324

FGA 18-22 20-24 18-20 8.9278

=2684954.3717 99.99%


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STR

1 2 3 4

TH01 7-9 7-9 7-9 6-9 7-9

VWA 14-17 15-17 14-17 15-19 14-18

FES 11-12 12-13 11-12 10-11 10-12

  • 399%

    1997


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  • 56 55

  • 203 6

  • 93.6%


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  • 1020""


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