Designer babies the future of reproductive technology
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Discussions Worth Sharing. Technology. Eugenics. Design. Designer Babies The Future of Reproductive Technology. Outline. Discussions worth Sharing. Background Who is it for Canadian statistics and regulations Discussions Reflections Future directions Summary. Objective.

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Designer Babies The Future of Reproductive Technology

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Designer babies the future of reproductive technology

Discussions

Worth

Sharing

Technology. Eugenics. Design

Designer BabiesThe Future of Reproductive Technology


Outline

Outline

Discussions worth Sharing

  • Background

  • Who is it for

  • Canadian statistics and regulations

  • Discussions

  • Reflections

  • Future directions

  • Summary


Objective

Objective

Discussions worth Sharing

  • General understanding of preimplantation genetic diagnosis (PGD) technology

  • Gain a wider perspective on cultural, religious and social implications

  • Think actively, discuss openly, participate!


Background

Background

Discussions worth Sharing

Designer Baby –

“a baby whose genetic make-up has been selected in order to eradicate a particular defect or to ensure that a particular gene is present”


Background1

Background

Discussions worth Sharing

Preimplantation Genetic Diagnosis (PGD)

  • Assisted human reproductive technology

  • Screening of embryos for genetic abnormalities prior to transferring to the uterus

  • In vitro fertilization consists of:

    1) Ovarian stimulation

    2) Egg retrieval

    3) Egg fertilization

    4) Embryo development

    5) Embryo transfer


Designer babies the future of reproductive technology

Who?

Discussions worth Sharing

  • Individuals or couples who are at risk to pass on a condition that is the result of a variant in a single gene

  • Individuals or couples with a chromosome condition, or who have had a previous child with a chromosome condition

  • Women who are at an increased risk to have a child with a chromosome condition due to their age


Canadian statistics 2010

Canadian Statistics - 2010

Discussions worth Sharing

  • 22 769 patients underwent in vitro fertilization over the past 5 years

  • 61% of fertility clinics responded (17 out of 28 clinics)

    • 6 performed embryo biopsy on site

    • 7 referred to other units in Canada

    • 3 referred to units in U.S.

  • Majority do not offer PGD due to:

    • Lack of resource/staff/money/expertise

    • No market demand

    • Not convinced it would yield accurate diagnosis


Regulations

Regulations

Discussions worth Sharing

  • Assisted Human Reproduction Act (2004)

  • Prohibited Activities

    • Create a human clone

    • Create an in vitro embryo for any purpose other than creating a human being

    • Maintain an embryo outside the body after 14 days of fertilization

    • Alter the genome of a cell of a human or in vitro embryo

    • Gender selection for non-medical reasons


Discussions

Discussions

Controversies


Designer babies the future of reproductive technology

Discussions worth Sharing


Discussions1

Discussions

Discussions worth Sharing

  • Selecting for a disability

“Being deaf is not about being disabled, or medically incomplete - it's about being part of a linguistic minority. We're proud, not of the medical aspect of deafness, but of the language we use and the community we live in.”


Designer babies the future of reproductive technology

Discussions worth Sharing


Discussions2

Discussions

Discussions worth Sharing

  • First born child: 76% have no gender preference

  • More than one child: 30% want equal number of girls and boys, and 58% have no preference

  • Using technology: 92% against it

  • Surveyed among pregnancy women: 58% had no gender preference

  • 234 surveyed:

  • 39% have no preference

  • 39% prefer a girl

  • 22% prefer a boy

  • Couples undergoing fertility treatment:40% would like to select the sex of their baby


Discussions3

Discussions

Discussions worth Sharing

  • Adam Nash

  • One of 15 embryos

  • Saved his sister suffering from Fanconi’sanaemia

  • Great achievement or unethical?


Reflection

Discussions worth Sharing

Reflection

Religious, Cultural, Societal Impacts


Religious impacts

Religious Impacts

Discussions worth Sharing

  • Dignitas Personae

  • “Preimplanation diagnosis…constitutes an act of abortion... By treating the human embryo as mere ‘laboratory material’, the concept itself of human dignity is also subjected to alteration and discrimination…Such discrimination is immoral and must therefore be considered legally unacceptable…”


Cultural impacts

Cultural Impacts

Discussions worth Sharing

  • India

    • Prefer boys

  • China

    • Country side

    • Prefer boys


Social impacts

Social Impacts

Discussions worth Sharing

  • Socioeconomic disparity

  • Discrimination

    • Social activists

    • Disability activists

  • Eugenics – “the science of improving a population by controlled breeding to increase the occurrence of desirable heritable characteristics”


Future directions

Future Directions

Discussions worth Sharing

  • More research, increased market demand, increased access to screening

    • More on-site PGD

  • More will choose PGD over other methods

  • When should it be refused?

  • What to regulate?

  • Should government provide funding?


Summary

Summary

Discussions worth Sharing

  • Science and technology is always evolving

  • No right or wrong views

  • Religious, cultural, societal influences

  • Keep an open mind

“The important thing in science is not so much to obtain new facts as to discover new ways of thinking about them.”

- Sir William Lawrence Bragg

More information at: http://futurebabies.weebly.com


References

References

Discussions worth Sharing

  • Collins M. Designing Rules for Designer Babies. Sci Am. 2009;300(5):29.

  • Crockin S. Adam Nash: legally speaking, a happy ending or slippery slope? Reprod Biomed Online. 2001;2(1):6-7.

  • Dahl E. Procreative liberty: the case for preconception sex selection. Reprod Biomed Online. 2003;7(4):380-4.

  • Edwards RG. Ethics of PGD: thoughts on the consequences of typing HLA in embryos.Reprod Biomed Online. 2004;9(2):222-4.

  • Klitzman R et. al. Anticipating issues related to increasing preimplantation genetic diagnosis use: a research agenda. Reprod Biomed Online. 2008;17 Suppl 1:33-42.

  • McMahon CA. Community concerns about sex selection: research as a way forward – response to Edgar Dahl’s ‘The presumption in favour of liberty’. Reprod Biomed Online. 2004;8(3):272-4.

  • Murphy TF. Choosing disabilities and enhancements in children: a choice too far? Reprod Biomed Online. 2009;18 Suppl 1:43-9.

  • Speechley KN, Nisker J. Preimplantation Genetic Diagnosis in Canada: A Survey of Canadian IVF Units. J ObstetGynaecol Can. 2010;32(4):341-7.

  • Steinbock B. Designer babies: choosing our children’s genes. Lancet. 2008;372(9646):1294-5.

  • Assisted Human Reproduction Canada. Legislation, Regulations and Guidelines. 12 Sept 2011. Available at http://www.ahrc-pac.gc.ca/v2/index-eng.php. Accessed March 8, 2013.

  • Carlson E. Image Archive on the American Eugenics Movement. Available at http://www.eugenicsarchive.org/html/eugenics/essay2text.html. Accessed March 8, 2013.

  • Kirkey S. Center For Genetics And Society. Embryo testing stokes concern over designer babies. 19 Sept 2011. Available at http://www.geneticsandsociety.org/index.php. Accessed March 8, 2013.

  • Lewis D. Infertility Awareness Association of Canada. Pre-Implantation Genetic Diagnosis Now Available to all Canadians! 2006. Available at http://www.iaac.ca/content/pre-implantation-genetic-diagnosis-now-available-all-canadians. Accessed March 8, 2013.

  • The Congregation for the Doctrine of the Faith. Instruction Dignitas Personae on certain Bioethical Questions. 8 Sept 2008. Available at http://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_20081208_dignitas-personae_en.html. Accessed March 8, 2013.


Questions

Questions

Discussions worth Sharing


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