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فرآورده های تشخيصی و تجهيزات مرتبط با آزمايش های انعقادی PowerPoint PPT Presentation


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فرآورده های تشخيصی و تجهيزات مرتبط با آزمايش های انعقادی. دکتر پريسا داهيم آزمايشگاه مرجع سلامت. سنجش زمان پروترومبين ( PT ). معرف : ترومبوپلاستين، مشتق از فاکتور بافتی TF (Tissue Factor) و ترکيب يک آپوپروتئين و فسفوليپيد است.

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فرآورده های تشخيصی و تجهيزات مرتبط با آزمايش های انعقادی

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(PT)

  • : TF (Tissue Factor) .

  • . Recombinant .

  • .


Isi international sensitivity index

ISI(international Sensitivity index)

  • ISI .

  • ISI IRP(International Reference Preparation ) ISI .

  • ISI .


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ISI

  • 20 60 . .


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  • ISI ISI .

  • PT ISI 1/5 1/2 .

  • ISI 2 .


Isi pt

ISI PT

  • PT 1983 INR(International Normalized Ratio) .

    patient PT ISI ISI INR= ( )

    mean of normal PT

    INR .


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  • ISI 1 INR .

  • ISI .

  • 1/4-1 42-26

  • 2-1/8 25-19


Pt 23 secs mean normal range 10 5 secs

PT=23 secs Mean normal range =10.5 secs


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(PT increasing from 23 secs to 25 secs will increase the INR

ISI 1 2.1 to 2.4

ISI 2 4.8 to 5.7


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  • IRP ISI

  • ISI .

  • .


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  • ISI ISI .


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PTT

  • :

  • 8 .

  • .


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  • 30% .

  • 40% 8 .

  • (0/5-0/05 ) .


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  • Pooled Plasma .


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  • 0/020 0/025

  • .


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  • :


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  • 20- 2 - 2

  • ()

CLSI EP5-A2Evaluation of Precision Performance of Quantitative Measurement Methods; Approved GuidelineSecond Edition

CLSI EP15-P User demonstration of Performance for precision and Accuracy Approved Guideline

Westgard

  • 5 2 .


Method comparison

METHOD COMPARISON

1- 40

2- 5 8 .

3- .

4- 5 .

5-correlation / coefficient 990. < r .

6- 99r<0. t-test .


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