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Biostatistics at the Medical University of Vienna

This article provides a historical account of the development of biostatistics at the Medical University of Vienna and explores the fields of activity of biostatisticians in Vienna. It discusses the origins of medical biostatistics in Austria and highlights the important contributions made by various departments and centers. The article also discusses methodological research, clinical cooperations, and teaching in the field of biostatistics in Vienna.

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Biostatistics at the Medical University of Vienna

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  1. Biostatistics at the Medical University of Vienna Michael Schemper Section for Clinical Biometrics Center for Medical Statistics, Informatics and Intellgent Systems Medical University of Vienna Vienna, Austria

  2. Contents: • Historical account on thedevelopmentofbiostatistics at the Medical University of Vienna • Whatarethefieldsofactivityofbiostatisticians at the Medical University of Vienna? Howaredemandsmet? Biostatistics in Vienna

  3. Origins of Medical Biostatistics in Austria Univ. of Vienna, 1969, Department of Medical Statistics and Documentation (Med. Faculty since 1365, became independent Med. University in 2004) Univ. of Innsbruck, 1968 Department of Biostatistics and Documentation Univ. of Graz, 1989, Department for Medical Informatics, Statistics and Documentation Section of Applied Statistics of the Dept of Statistics, Techn.Univ. of Graz (several years earlier) Biostatistics in Vienna

  4. CeMSIIS (Center for Med.Stat., Inf.& Intell.Syst.), *2010 Sc. ofComplex Syst. Core Unit forMed.Stat. & Inf., 2004 - 2010 Dept. forArtif. Intell., 1977 - 2010 Dept. forMed.Comp.Sc., 1973 – 2004 Computing Center 1966 - 2003 Dept. forMed.Stat. & Doc. 1969 - 2004 Clinical Biometrics * 1991 Biostatistics in Vienna

  5. CeMSIIS (Center for Med.Stat., Inf.& Intell.Syst.), *2010 Sc. ofComplex Syst. Core Unit forMed.Stat. & Inf., 2004 - 2010 Dept. forArtif. Intell., 1977 - 2010 Physiology Dept. forMed.Comp.Sc., 1973 – 2004 Computing Center 1966 - 2003 Dept. forMed.Stat. & Doc. 1969 - 2004 Physiology Internal Medicine Clinical Biometrics * 1991 Surgery

  6. Relative magnitudeof human resources Employees of CeMSIIS: ~ 75 (50% in statistical sections) Scientific employees of the Med. Univ. of Vienna: ~ 3600 CeMSIIS has ~2% and ~1% are statisticians (CeMSIIS is one of 12 theoretical centers or institutions) Biostatistics in Vienna

  7. Biostatistics in Vienna

  8. Methodologicalresearch • Survivalanalysis • Explainedvariation • Regression problems, such asmissingcovariatevalues • Analysis of high-dimensional (omics-) data • Small sample analysis • Clinical trialsmethodology • Big data Biostatistics in Vienna

  9. Methodological Research bythe • Sectionfor Medical Statistics: • Sequential experimental designs • Adaptive and flexible experimental designs • Multiple hypothesestesting • Designs forhypothesesselection in geneticstudies Biostatistics in Vienna

  10. Development ofstatisticalsoftware:

  11. Clinical cooperations • Planingandanalysisofclinicalstudies, in particular • Prospective (multicenter) treatmentstudies • Observationalstudies • Prognosticfactorstudies – predictionmodels • Diagnosticstudies • Omicsstudies • Metaanalyses • Planningandanalysisofexperiments (animalstudies, studieswithhealthyvolunteers; advanced ANOVA) • Development ofgrowthcharts • Consulting on generalstatisticalissues

  12. Scientific output per year (average of last 5 years) • Methodological research: 6 • Clinical cooperations: 45 Biostatistics in Vienna

  13. Teaching:

  14. Further scientificactivitiesofbiostatisticians • at the Med. University: • Committeework (in particularfortheEthicsandAnimalEthicsCommitteesofthe Med. University) • Editor-functions in Journals • Organizationofscientificconferences (LOC, SPC) • Mobility ofresearchers (incomingandoutgoing) • Grant acquisition Biostatistics in Vienna

  15. Some Credos: • Importanceofpracticefor relevant methodologicalwork • Goodteamwork essential • Imagination moreimportantthanknowledge Biostatistics in Vienna

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