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Yeni Küresel Viral Tehditler

Yeni Küresel Viral Tehditler. Doç. Dr. Hakan Erdem TTD, 17.Yıllık Kongre 2-6 Nisan 2014. 04.04.2014. http://wwwnc.cdc.gov/travel/notices. Sunum Planı. Türkiye’yi de etkileyen küresel viral tehditler İnfluenza hariç… MERS- CoV Batı Nil Virüs Hantavirüs Kırım Kongo kanamalı ateşi.

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Yeni Küresel Viral Tehditler

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  1. Yeni Küresel Viral Tehditler Doç. Dr. Hakan Erdem TTD, 17.Yıllık Kongre 2-6 Nisan 2014

  2. 04.04.2014 http://wwwnc.cdc.gov/travel/notices

  3. Sunum Planı • Türkiye’yi de etkileyen küresel viral tehditler • İnfluenza hariç… • MERS-CoV • Batı Nil Virüs • Hantavirüs • Kırım Kongo kanamalı ateşi

  4. Viral Yıkımlar

  5. Trachoma 0,70% Gonorrhoea 0,70% Bronchitis 2,40% Malaria 2,50% Syphilis 3,50% Influenza 7,20% Pleuropneumonia 23,40% Erysipelas 25% Relapsing fever 30% Mortality Rates Pneumonia 31,50% Dysenteriae 38,90% Smallpox 40% 41,80% Extrapulmonarytbc Typhus 44,50% Typhoid fever 51,20% Pulmonary tbc 58,50% Cholera 80,30% Erdem H, et al. War and infection in the preantibiotic era; the third Ottoman Army in 1915, ScandJ Infect Dis. 2011:43(9): 690-695. HE-6

  6. Viral Salgınlar

  7. Enfeksiyon Klinikleri-1 Nisan 2012. Üniversite Hastaneleri HIV, USYE, Viral Hepatit Erdem H, et al. Infectious Diseases Departments and Patients in the UniversityHospitals in Turkey. Journal of Infectious Diseases and Therapeutics, (in press)

  8. Enfeksiyon Klinikleri-1 Haziran-Temmuz 2013 HIV: Fransa‘da % 14, Türkiye’de % 4 KKKA: Türkiye’de % 2.8 Erdem H, Stahl JP, Inan A, et al. The features of infectious diseases departments and anti-infective practices in France and Turkey: A cross sectional study. Eur J Clin Microbiol Infect Dis (in press)

  9. 12 Ülkeden 88 YBU Haziran-Temmuz 2012 1/749 (Saraybosna), Hantavirüs enfeksiyonu (HFRS) Erdem H, Inan A, Elaldi N, et al. Surveillance, control and management of infections in ICUsin southern Europe, Turkey and Iran-a prospective multicenter point prevalence study. Journal of Infection 2014; 68: 131-140.

  10. Tanısal refleks zayıf… 19 Merkez, 445 YBU’da TGP hastası • Vakaların %20’sinde hiç kültür alınmamış • % 80 kişiselleşen yaklaşımlar Erdem H, Turkan H, Cilli A, et al. Mortality indicators in CAP requiring intensive care in Turkey. International Journal of Infectious Diseases 2013: 17(9): e768-e772

  11. Tüm tanısal imkanlar kullanılmalı…

  12. MERS-CoV

  13. Corona Virüsler

  14. MERS-CoV Ciddi akut solunumsal hastalık Mortalite % 42, komorbidite ile 15 http://www.cdc.gov/coronavirus/MERS/

  15. There have been, as of yet, no confirmed cases ofHajjassociatedMERS-CoVin Saudi Arabia or abroad RashidH, et al. Has Hajj-associated Middle East Respiratory Syndrome Coronavirus transmission occurred? The case for effective post-Hajj surveillance forinfection Clinical Microbiology and Infection2014; 20(4): 273-76.

  16. Türkiye’den henüz vaka bildirimi yok…

  17. İngiltere Kümesi

  18. MERS-CoV, Gelecek???

  19. Batı Nil Virüsü

  20. BNV-Tarihçe • Flaviviridae ailesinden bir flavivirüs • 1937’de Uganda… • 1994 Cezayir paniği… • 1996 Romanya salgınları • 1999’da New York, 5 yıl içinde tüm ABD

  21. BNV İnfeksiyonu • % 80 subklinik • % 1 ciddi seyir, nöroinvazif • Risk grupları • Yaşlılar • Çocuklar • Bağışıklığı baskılanmış hastalar Nash D, et al. "The outbreak of West Nile virus infection in the New York City area in 1999". N. Engl. J. Med. 2001:344 (24): 1807–14.

  22. İlk Vakalar • 2010, 15 ilde • 47 vaka (12 kesin, 35 olası) • Insidans 0.19/100.000 • Sakarya’da en yüksek 1.39 • 40/47 SSS tutulumu Kalaycioglu H. Et al. Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011. Euro Surveill. 2012 May 24;17(21). pii: 20182..

  23. Ankara’dan bir vaka… • Hacettepe UTF • 87 yaşında kadın hasta • BNV ensefaliti • EEG/MR, gerileme • 10. hafta • Nozokomiyalinfeksiyonlara bağlı kaybedildi Ocal M, et al. A case of central nervous system infection due to west nile virus lineage-1 in ankara province, Turkey. Mikrobiyol Bul. 2013 ;47(1):164-72.

  24. Konya, Sivas, Yozgat BNV seroprevalensi % 0.56 (Plak nötralizasyon ile konfirme edilmiş) Ergunay,K, et al. West Nile virus seroprevalence in blood donors from Central Anatolia, Turkey. Vector Borne Zoonotic Dis. 2010;10(8):771-5.

  25. Karakoç ZÇ, et al. West nile virus infection in the mesopotamia region, Syria border of Turkey. Vector Borne Zoonotic Dis. 2013 :13(10):739-43.

  26. Memelilerde BNV Prevalensi • 70’er tane • Sığır, at, keçi, koyun ve manda • 2 keçi (% 0.6) seropozitif Albayrak H, et al. SeroepidemiologicalStudy of West Nile Virus and Rift Valley Fever Virus in Some of Mammalian Species (Herbivores) in Northern Turkey. J ArthropodBorneDis. 2013; 7(1): 90–93.

  27. Batı Nil Virüsü • Hastalar (+) • Vektörler (+) • Sereprevalens % 1.7 Erdem H, Ergunay K, Yilmaz A, et al. Emergence and co-infections of West Nile virus and Toscana virus in Eastern Thrace, Turkey.ClinMicrobiolInfect. 2014 ;20(4):319-25.

  28. Ergunay,K, et al. Arboviral surveillance of field-collected mosquitoes reveals circulation of West Nile Virus Lineage 1 strains in Eastern Thrace, Turkey. Vector-Borne and Zoonotic Diseases 2013;13(10):744-52

  29. Hantavirüsİnfeksiyonları

  30. İnsandan insana bulaş yok…

  31. Türkiye’den Vakalar Erdem H, Akova M. Leading infectious diseases problems in Turkey. ClinMicrobiolInfect 2012; 18: 1056–1067

  32. Giresun Bölgesinde seroprevalens % 3.2 Gozalan A, et al. Human puumalaanddobravahantavirusinfections in the Black Searegion of Turkey: A cross-sectionalstudy. VectorBorneZoonoticDis. 2013;13(2):111-8.

  33. HFRS-Klinik Bulgular

  34. Kongo Kırım Kanamalı Ateşi

  35. KKKA Virüsü • Bunyaviridae’dan bir Nairovirus

  36. 2002-2003 2004 2005 2006

  37. Türkiye’de 2013 yılında 5000 örnekte 900 civarında pozitiflik…

  38. KKKA; Mortalite % 5-30

  39. KKKA, Bulaş

  40. Hyalomma’nın Epidemiyolojik Dağılımı Vatansever, Z, et al. In: CCHF. Ergonul & Whitehouse, Springer, 2007

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