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HIV RISK REDUCTION AND SUBSTANCE ABUSE TREATMENT. George E. Woody, M.D. Department of Psychiatry, University of Pennsylvania and Department of Veterans Affairs, Philadelphia, PA. Overview of HIV Rise in NYC Among IDUs (Kreek et al). 1978-1984: Increase from 0 to about 55% overall

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Hiv risk reduction and substance abuse treatment
HIV RISK REDUCTION AND SUBSTANCE ABUSE TREATMENT

George E. Woody, M.D.

Department of Psychiatry, University of Pennsylvania and Department of Veterans Affairs, Philadelphia, PA


Overview of hiv rise in nyc among idus kreek et al
Overview of HIV Rise in NYC Among IDUs (Kreek et al)

  • 1978-1984: Increase from 0 to about 55% overall

  • Leveling off at 50-55%, then a slow decrease beginning around 1992


HIV-1 Infection in Intravenous Drug Users In New York City: 1983 - 1984 Study: Protective Effect of Methadone Maintenance (Kreek et al)

50 – 60% of untreated, street heroin addicts test positive for HIV-1

9% of methadone continuously maintained since <1978 test positive



Methadone levels study
Methadone Levels Study Enrollment In Study


Reasons for hiv risk reduction in methadone maintenance
Reasons for HIV Risk Reduction in Methadone Maintenance Enrollment In Study

  • Abstinence

  • If don’t stop drug use completely almost always reduce it substantially (e.g. reduction in severity of the target symptom)

  • Fewer injections

  • Exposure to risk reduction counseling and other information in treatment program


Nida cocaine collaborative treatment study crits christoph et al

NIDA Cocaine Collaborative Treatment Study Enrollment In StudyCrits-Christoph et al

Random assignment to:

group drug counseling alone (GDC)

individual drug counseling (IDC) plus GDC

cognitive therapy (CT) plus GDC

supportive-expressive therapy (SE) plus GDC.


6-month active phase and a 3-month booster phase. Enrollment In Study

GDC sessions were 1.5 hours weekly throughout the 6-month active phase.

Oriented toward helping patients stop cocaine use and

Facilitating participation in 12-step programs

Included education about HIV risk reduction.


Individual therapy sessions for IDC, CT and SE therapy were: Enrollment In Study

50 minutes twice weekly for the first 12 weeks

Then weekly during weeks 13-24.

Monthly individual sessions held during the booster phase in months 7-9.


Patients recruited by advertisements, from substance abuse treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.

Patients 18-60 years of age, principal DSM-IV diagnosis of cocaine dependence that was current or in early partial remission, and had used cocaine >1 day in the past 30 days.


Exclusion criteria

Exclusion criteria: treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.

Unstable living situations

Inability to give informed consent

Opioid or polysubstance dependence (current or in early remission)

Major psychiatric disorder other than cocaine dependence

Needing to be maintained on psychotropic medication

Life-threatening or unstable medical condition

Serious legal problems such as impending incarceration, living in a halfway house, being in a hospital for more than 10 of the past 30 days

Scheduling problem that made it difficult to keep regular appointments.


Exclusion criteria cont d

Exclusion criteria (cont’d): treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.

Patients invited for an intake visit after being screened by telephone

At intake visit study explained and informed consent obtained.

Patients then began a screening/stabilization phase designed to select those with enough motivation to participate in an outpatient study.

Patients required to attend three visits within 14 days, including one group session and two case management sessions as a test of their ability to comply with study requirements.


- 2197 patients screened treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.

- 1771 met basic inclusion criteria and scheduled for an intake visit,

- 937 reported for intake

- 870 began orientation

- 487 completed required number of appointments & randomized.


Five sites participated

Five sites participated treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers. :

Western Psychiatric Institute and Clinic

University of Pennsylvania

Brookside Hospital (Nashua, NH)

Massachusetts General Hospital

McLean Hospital (Belmont, MA).


Randomized patients had

Randomized patients had: treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.

Average age of 34

Lived alone (70%),

13 years of education

Were employed (60%)

Male (77%); Caucasian (58%)

40% African-American; 2% were Latino/a.


Crack smoking the most common (79%) treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.

19% intranasal cocaine

2% used intravenously.

Average patient used cocaine for 7 years and reported 10 days of cocaine use and 7 days of alcohol use in the last month.


Following randomization, patients kept about half their scheduled appointments during the six-month active treatment phase.

HIV risk measured by RAB

A self-report instrument that takes 10-15 minutes to complete

Measures behaviors that are associated with HIV risk.

Focuses on drug use during the past 30 days, and

Injection and sexual risk during the past 6 months


For example, in response to the question: “In the past six months, how often have you given drugs to someone so you could have sex with them?”

Respondent asked to check one of seven items ranging from “never” to “more than once a day”.


Sixteen questions used to calculate three composite HIV risk scores:

Drug score

Sex score

Total score.

Scores for a single question can range from 0 to 7,

with higher values reflecting more instances of risk behavior.


Of the 487 patients who were randomized, 483 completed the RAB at study intake and 331 completed it at both intake and six months. The data presented here report RAB data from the 331 participants who completed it at both assessment points.


Overall Results: RAB at study intake and 331 completed it at both intake and six months. The data presented here report RAB data from the 331 participants who completed it at both assessment points.

Drug Use: Treatment associated with significant decreases in cocaine use across all groups with the average patient reducing use from 10 days/month to one day/month at the six-month assessment.


Average ASI drug use composite score decreased from 0.24 at intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.

A significant treatment main effect, with patients who received IDC + GDC showing less cocaine use at 6 months than patients in the other three treatment conditions (13).


HIV Risk Reduction intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.

Consistent with the crack smoking pattern of most patients, almost all HIV risk was in the sexual area and treatment participation was associated with a substantial reduction in sex risk and in total risk (primarily due to the reduction in sex risk), as seen in tables 1a and 1b.


Treatment intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.

Condition

Baseline

Adjusted Mean

Month 6

Adjusted Mean

IDC (n=77)

5.69 a

3.39 b

CT (n=85)

6.63 a

3.87 b,c

SE (n=85)

6.17 a

4.71 c

GDC (n=84)

6.27 a

3.68 b

TABLE 1a: Change in RAB Sex Risk and Treatment Condition*

*Analyses of difference in means controlled by baseline assessment; means followed by the same letter are not statistically different (p>0.05)


Treatment intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.

Condition

Post-orientation

Adjusted Mean

Month 6 Adjusted Mean

IDC (n=77)

5.90 a

3.40 b

CT (n=85)

6.96 a

3.95 b,c

SE (n=85

6.20 a

4.83 c

GDC (n=84)

6.45 a

3.80 b

TABLE 1b: Change in RAB Total Risk and Treatment Condition*

* Analyses of difference in means controlled by baseline assessment; means followed by the same letter are not statistically different (p>0.05)


Figure 1: intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.


Figure 3: intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.


Summary
Summary intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.

  • Treatment is associated with HIV risk reduction

  • Shown to reduce HIV infection in case of methadone maintenance

  • Mechanisms differ according to drug of choice but similar in that all associated with less drug use

  • For injecting use - fewer injections;

  • For non-injecting use - less unprotected sex; less exchanging sex for drugs

  • Alcohol dependence associated with increased sexual risk, probably due to impaired judgment; rx probably reduces but few studies


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