HIV RISK REDUCTION AND SUBSTANCE ABUSE TREATMENT. George E. Woody, M.D. Department of Psychiatry, University of Pennsylvania and Department of Veterans Affairs, Philadelphia, PA. Overview of HIV Rise in NYC Among IDUs (Kreek et al). 1978-1984: Increase from 0 to about 55% overall
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George E. Woody, M.D.
Department of Psychiatry, University of Pennsylvania and Department of Veterans Affairs, Philadelphia, PA
50 – 60% of untreated, street heroin addicts test positive for HIV-1
9% of methadone continuously maintained since <1978 test positive
NIDA Cocaine Collaborative Treatment StudyCrits-Christoph et al
Random assignment to:
group drug counseling alone (GDC)
individual drug counseling (IDC) plus GDC
cognitive therapy (CT) plus GDC
supportive-expressive therapy (SE) plus GDC.
6-month active phase and a 3-month booster phase.
GDC sessions were 1.5 hours weekly throughout the 6-month active phase.
Oriented toward helping patients stop cocaine use and
Facilitating participation in 12-step programs
Included education about HIV risk reduction.
Individual therapy sessions for IDC, CT and SE therapy were:
50 minutes twice weekly for the first 12 weeks
Then weekly during weeks 13-24.
Monthly individual sessions held during the booster phase in months 7-9.
Patients recruited by advertisements, from substance abuse treatment programs, referrals from friends or acquaintances, mental health centers, and private mental health providers.
Patients 18-60 years of age, principal DSM-IV diagnosis of cocaine dependence that was current or in early partial remission, and had used cocaine >1 day in the past 30 days.
Unstable living situations
Inability to give informed consent
Opioid or polysubstance dependence (current or in early remission)
Major psychiatric disorder other than cocaine dependence
Needing to be maintained on psychotropic medication
Life-threatening or unstable medical condition
Serious legal problems such as impending incarceration, living in a halfway house, being in a hospital for more than 10 of the past 30 days
Scheduling problem that made it difficult to keep regular appointments.
Exclusion criteria (cont’d):
Patients invited for an intake visit after being screened by telephone
At intake visit study explained and informed consent obtained.
Patients then began a screening/stabilization phase designed to select those with enough motivation to participate in an outpatient study.
Patients required to attend three visits within 14 days, including one group session and two case management sessions as a test of their ability to comply with study requirements.
- 2197 patients screened
- 1771 met basic inclusion criteria and scheduled for an intake visit,
- 937 reported for intake
- 870 began orientation
- 487 completed required number of appointments & randomized.
Five sites participated:
Western Psychiatric Institute and Clinic
University of Pennsylvania
Brookside Hospital (Nashua, NH)
Massachusetts General Hospital
McLean Hospital (Belmont, MA).
Randomized patients had:
Average age of 34
Lived alone (70%),
13 years of education
Were employed (60%)
Male (77%); Caucasian (58%)
40% African-American; 2% were Latino/a.
Crack smoking the most common (79%)
19% intranasal cocaine
2% used intravenously.
Average patient used cocaine for 7 years and reported 10 days of cocaine use and 7 days of alcohol use in the last month.
Following randomization, patients kept about half their scheduled appointments during the six-month active treatment phase.
HIV risk measured by RAB
A self-report instrument that takes 10-15 minutes to complete
Measures behaviors that are associated with HIV risk.
Focuses on drug use during the past 30 days, and
Injection and sexual risk during the past 6 months
For example, in response to the question: “In the past six months, how often have you given drugs to someone so you could have sex with them?”
Respondent asked to check one of seven items ranging from “never” to “more than once a day”.
Sixteen questions used to calculate three composite HIV risk scores:
Scores for a single question can range from 0 to 7,
with higher values reflecting more instances of risk behavior.
Of the 487 patients who were randomized, 483 completed the RAB at study intake and 331 completed it at both intake and six months. The data presented here report RAB data from the 331 participants who completed it at both assessment points.
Drug Use: Treatment associated with significant decreases in cocaine use across all groups with the average patient reducing use from 10 days/month to one day/month at the six-month assessment.
Average ASI drug use composite score decreased from 0.24 at intake where 100% reported cocaine use in the last month, to an average of 0.12 at 6 months, where 50% reported any cocaine use in the last month.
A significant treatment main effect, with patients who received IDC + GDC showing less cocaine use at 6 months than patients in the other three treatment conditions (13).
HIV Risk Reduction
Consistent with the crack smoking pattern of most patients, almost all HIV risk was in the sexual area and treatment participation was associated with a substantial reduction in sex risk and in total risk (primarily due to the reduction in sex risk), as seen in tables 1a and 1b.
TABLE 1a: Change in RAB Sex Risk and Treatment Condition*
*Analyses of difference in means controlled by baseline assessment; means followed by the same letter are not statistically different (p>0.05)
Month 6 Adjusted Mean
TABLE 1b: Change in RAB Total Risk and Treatment Condition*
* Analyses of difference in means controlled by baseline assessment; means followed by the same letter are not statistically different (p>0.05)