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Going Against the Grain

Going Against the Grain. Overview of this experiment. Diagnose D. Atkins using: Symptoms Phosphatase isoforms found in serum Identify source of excess phosphatase. Our Strategy. Step One: pH assay. Our Strategy . Step 2: Inhibitor Assay. Our Strategy. D. Atkins Patient Information.

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Going Against the Grain

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  1. Going Against the Grain

  2. Overview of this experiment • Diagnose D. Atkins using: • Symptoms • Phosphatase isoforms found in serum • Identify source of excess phosphatase

  3. Our Strategy

  4. Step One: pH assay

  5. Our Strategy

  6. Step 2: Inhibitor Assay

  7. Our Strategy

  8. D. Atkins Patient Information Name: D. AtkinsAge: 28Sex: Female Symptoms: abdominal pain, fatigue, diarrhea, and nauseaD. Atkins has experienced a recent development of lactose intolerance, although she has never had this issue before

  9. Diagnostic Tests -Assays--renal alkaline phosphatase level elevation Additional Tests:-Blood test --presence of anti-endomysium antibodies (EMA)-Intestinal biopsy --flattening of villi-Genetic tests

  10. Diagnosis Ciliac’s Disease

  11. What is Celiac’s Disease? • Condition that damages small intestine lining and prevents it from absorbing parts of food • Reaction to eating gluten • What does gluten affect? • Intestine lining “villi” • Immune system damages villi • Affects proper nutrient absorption

  12. Development of Disease • Exact cause unknown • Develops at any point in life • Family members with Celiac’s are at greater risk • More common in women

  13. Signs of Celiac’sDisese • High levels of alkaline phosphatase • Abnormal clotting • Low cholesterol

  14. Symptoms of Celiac’s Disease • Primarily gastrointestinal symptoms • Lactose intolerance • Nausea and vomitting • Constipation, diarrhea, bloating • Some develop over time • Depression or anxiety, fatigue

  15. Treatment • Gluten-Free Diet • Vitamins and minerals • Support groups and dieticians

  16. Prognosis • Gluten-Free Diet and Dietician • Villi should heal within 1-2 years • Follow-up biopsy in 1-2 years • Reevaluate diet • Should maintain normal health with vitamins and minerals

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